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Biomedical subjects

V Skorpil

Publications and source records attributed to V Skorpil.

9 recordsLinked to original sources
PubMed1985

Pyridoxine megavitaminosis: an analysis of the early changes induced with massive doses of vitamin B6 in rat primary sensory neurons.

The early effects of high toxic doses of vitamin B6 (pyridoxine) on the peripheral sensory neurons were studied in laboratory rats. The animals were treated with 600 mg/kg of pyridoxine hydrochloride by intraperitoneal injection twice daily. Thereafter they were killed by perfusion-fixation at periods ranging from one to 14 days and the tissues were examined by light and electron microscopy. The primary change consisted of the formation of swollen membranous profiles in both the axon hillock and the initial axonal segment of the large dorsal root cytons. This change occurred within 24 hours of exposure, and was followed by an axonal reaction of the nerve cell bodies and by secondary degeneration of their processes. These findings identify the probable target site for pyridoxine toxicity, and establish a simple animal model for studying not only sensory denervation, but also the axonal reaction and secondary degeneration.

Animals↗
PubMed1976

[Decompression of individual nerves in anatomical strictures in polyneuropathies].

During clinical and electromyographical examination of one patient with diabetic and one with alcoholic polyneuropathy we found an especially severe lesion of the ulnar nerve at the elbow on one side. As the polyneuropathy generally affects the nerves symmetrically we presumed in addition some other most probably ulnar nerve compression syndrome at the elbow. Both patients were operated and the nerves were transposed (Prof. NIGST). The local finding during the operation, the improvement of the paresis of ulnar nerve and the worsening of the polyneuropathy--found simultaneously at control after 2 and 4 years--confirmed our supposition. Should in cases of polyneuropathy an especially severely damaged nerve be found, one ought to think of the possibility of an additional mechanical lesion and treat the patient accordingly.

Alcoholism↗
PubMed1976

[Diagnostic importance of electrophysiologic tests in Bell's palsy: report on a longterm follow-up study in 100 cases (author's transl)].

The present study is based upon the results of repeated electrodiagnostic tests carried out in a series of 100 cases of Bell's palsy (Determination of Rheobase and Chronaxy). The first symptoms of denervation can be observed during the second week after the onset of the paralysis. This seems to be the critical period in which the ultimate consequences of the lesion are determined: partial or total recovery or complete irreversible denervation. In cases showing a rapid increase of chronaxy during the 2nd week, prognosis is rather poor because a difference of 240% between the affected and the normal side indicates a progressive denervation. Cases in which the difference of chronaxy values during the 2nd week is increased upto 240% (i.e. partial denervation) recover incompletely in 15% of the cases. Estimation of prognosis in Bell's palsy and timing of a facial nerve decompression must be based on reliable facts, such as the results of repeated electrodiagnostic tests (modified measurement of Rheobase and Chronaxy) carried out at least every secont but preferably every day during the first 3 weeks after the onset of the paresis.

Chronaxy↗
PubMed1975

Facial myokymia.

43 patients with facial myokymia were examined clinically and electromyographically over periods of up to 13 years. 18 patients were suffering from multiple sclerosis, 6 patients from brain stem tumour or tumours of the posterior cranial fossa, and 19 from other known or unknown neurological disorders. Duration, recurrences, EMG results of myokymia and its accompanying neurological symptoms are discribed.

Adolescent↗