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Biomedical subjects

V Stephan

Publications and source records attributed to V Stephan.

39 records · Page 3Linked to original sources
PubMedDate not supplied

Prospective study of fever after bronchoalveolar lavage in children.

BACKGROUND: We investigated the significance of bronchoalveolar lavage fluid (BALF) characteristics and bacterial pathogens isolated in bronchoalveolar lavage fluids, oropharyngeal cultures and blood cultures for the development of fever in children after flexible bronchoscopy. METHOD: We studied 41 consecutive patients (age 4 months to 15 years), who underwent bronchoalveolar lavage (BAL) and 24 hours temperature monitoring. Two blood cultures of each patient drawn at two sites, oropharyngeal swabs, total cell counts, cell differentials and microbial cultures from lavage fluid were studied. RESULTS: Postbronchoscopic temperature increase was significantly higher in patients with positive BALF cultures (p = 0.04). Seven out of 41 patients had postbronchoscopic fever and positive bacterial cultures of BALF. Bacteraemia (with an identical pathogen isolated in BALF) was found in one febrile patient. There was a significantly higher total cell count (p = 0.03) and concentration of neutrophils (p = 0.001) in BALF among the children with presence of positive bacterial cultures. CONCLUSION: We conclude that fever is a frequent adverse event following BAL in children and is rarely associated with bacteraemia. Findings associated with the risk to develop fever are positive bacterial cultures and high neutrophil numbers in BALF.

Adolescent↗
PubMedDate not supplied

[Maternal tobacco consumption can be reduced by simple intervention of the paediatrician].

BACKGROUND: Exposure to environmental tobacco smoke at home increases the risk for numerous diseases in childhood. In this study we asked if maternal tobacco consumption can be reduced by a written advice of the paediatrician. PATIENTS AND METHODS: In a paediatrician's practice we recruited 40 mothers who smoked ten or more cigarettes per day according to their own statement. The paediatrician's intervention consisted in a short written advice to reduce tobacco consumption. At the beginning of the study and six weeks later we obtained urine samples of the mothers in order to measure the concentrations of the nicotine metabolite cotinine. A subgroup of the study population was informed about the initial concentration of cotinine, the other subgroup was not informed. MAIN RESULTS: Following the written advice of the paediatrician mothers reduced their consumption of tobacco products according to their own information as well as according to the concentrations of cotinine. Confronting mothers with their initial concentrations of cotinine was not found to be an additional factor reducing tobacco consumption. CONCLUSIONS: Maternal consumption of tobacco products can be reduced significantly by an advice of the paediatrician at least for a short time.

Adult↗