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Biomedical subjects

V Stroescu

Publications and source records attributed to V Stroescu.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

Studies regarding the efficiency of Supro isolated soy protein in Olympic athletes.

66 Romanian olympic endurance athletes (30 kayak-canöe, 36 rowing; 45 males and 21 females) participated in our trial, for the purpose to make evident possible biological effects of Supro isolated soy protein supply (1.5 g/kg/day, 8 weeks). At random the athletes were divided into two groups: A group (n = 38) and B group (n = 28). Daily programme (4-6 hours daily, endurance and strength), food and medication were similar for all athletes. The athletes of the A group received daily 1.5 g/kg SuproR soy protein, for 8 weeks while the athletes of the B group did not received soy protein supply. Two months soy protein supply induced increases of body mass (about 3 kg, especially by lean body mass), strength indexes, serum proteins, haemoglobin and total calcium and significant decreases of urinary mucoproteins and fatigue after training sessions, especially when comparing to the athletes of the B group. No damages of liver, kidney and metabolism tests were noticed in all athletes; no side effects were noticed and the product was well tolerated by athletes. When applying the cross-over method for other 2 months we obtained the same results. Based on these data the authors support the idea of a beneficial effect of this soy protein supply on the biological preparation of endurance top athletes.

Adult↗
PubMedDate not supplied

Experimental research about the influence of pentazocine and reserpine on morphine addiction.

By means of a conveyer belt two types of conditioned reflexes were developed in rats, at two functional levels. When these had become stable, we observed the animals' behaviour during a morphine treatment, until they developed tolerance. Thereafter the treatment with morphine was suddenly discontinued, or morphine was replaced by pentazocine or reserpine. We found that morphine impaired both types of conditioned reflexes and that ni about two weeks drug tolerance appeared. When treatment was discontinued a syndrome of abstinence developed, which exclusively impaired the conditioned reflex of the second order. Pentazocine and reserpine prevent such manifestation of the abstinence syndrome. Moreover, reserpine suppresses the tolerance to morphine. Concerning these results we suppose that opioid receptors type mu are involved in behavioural trouble produced by morphine, while opioid receptors type k are involved in the abstinence syndrome. Certain adrenergic mechanisms operate both in the development of tolerance and in behavioural modifications caused by the syndrome of abstinence.

Animals↗
PubMedDate not supplied

Studies regarding the effects of an antioxidant compound in top athletes.

The authors performed a controlled trial in 15 top junior athletes (road cyclists) in order to make evident some antioxidant effects of a new compound, containing selenium, vitamin E, glutathion and cysteine, prepared as tablets. Nonproteic -SH and lipid peroxides (MDA) in blood have been recorded initially on basal conditions and 3 weeks later--during the time the athletes received daily, before training session, 2 h cycling on road about 70km--2 tablets of the antioxidant product (respectively placebo). Then, after one week we applied the cross over method. 3 weeks of antioxidant treatment induced significant increase of the nonproteic -SH and significant decrease of the lipid peroxides (MDA), especially in comparison with placebo treatment. These results support the idea of some antioxidant effects of this compound which might be useful in the biological preparation of endurance athletes.

Antioxidants↗
PubMedDate not supplied

Studies regarding the antioxidant effects of selenium on top swimmers.

The authors performed another controlled trial in 33 top swimmers (16 girls and 17 boys) in order to make evident some acute and chronic effects (antioxidant) of selenium. Lipid peroxides (MDA-malondialdehyde), nonproteic--SH (essential glutathione) in the serum and blood lactate had been recorded initially on basal conditions and after 2 h endurance training (swimming) accompanied by a per oral administration of 150 micrograms selenium (respectively placebo); one week later we applied the cross-over method. In another trial we continued the treatment with 100 micrograms selenium daily for 14 days (n = 9), respectively placebo (n = 7) and then we applied the crossover method for another 14 days. The above biochemical parameters were recorded initially at rest, under basal conditions, after 14 days of treatment and again after 14 days of treatment, when crossing-over. No significant changes were noticed after a single dose + 2 h hard training, both under selenium and placebo treatment and also when the cross-over method was applied. Fourteen days of selenium treatment induced significant changes of lipid peroxides (especially when the subjects came after placebo) and nonproteic--SH, compared to placebo, changes which support the idea of some antioxidant effects of selenium which might be useful in endurance athletes.

Administration, Oral↗
PubMedDate not supplied

Experimental research of the influence of the body electrolytic composition on the toxic effect of morphine.

The ionic composition of the internal environment influences the toxic effect of morphine. LD50 for morphine and thiopental was tested in 3 lots of mice: with sodium depletion, with sodium load, and with normal sodium content in the food. LD50 for morphine was clearly influenced by the treatment received by the animals. Since such differences could not be found with thiopental, we consider that the ionic composition of the internal environment could modify the steric conformation of the receptor-macromolecule for opioids.

Animals↗