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V Sukthomya

Publications and source records attributed to V Sukthomya.

5 recordsLinked to original sources
PubMed2000

High-dose-rate afterloading brachytherapy in carcinoma of the cervix: an experience of 1992 patients.

PURPOSE: To report the results of radiation therapy in carcinoma of the cervix treated by external irradiation and high-dose-rate (HDR) intracavitary brachytherapy. METHODS AND MATERIALS: This is a retrospective analysis of 2,063 patients with histologically proven carcinoma of the cervix treated by external irradiation and HDR intracavitary brachytherapy between March 1985-December 1991. The Kaplan-Meier method was used for survival and disease-free survival analysis. Late complications in the bowel and bladder were calculated actuarially. RESULTS: There were 71 patients who did not complete the course of irradiation so only 1992 patients were retrospectively analyzed for survival. There were 2 patients (0.1%) in Stage IA, 211 (10.2%) Stage IB, 225 (10.9%) in Stage IIA, 902 (43. 7%) in Stage IIB, 14 (0.7%) in Stage IIIA, 675 (32.7%) in Stage IIIB, 16 (0.8%) in Stage IVA, and 16 (0.8%) in Stage IVB. The median follow-up time was 96 months. The actuarial 5-year disease-free survival rate was 79.5%, 70.0%, 59.4%, 46.1%, 32.3%, 7.8%, and 23.1% for Stage IB, IIA, IIB, IIIA, IIIB, IVA, and IVB respectively. The actuarial 5-year disease-free survival rate for Stage IB(1) and IB(2) squamous cell carcinoma was 88.7% and 67.0%. The actuarial 5-year overall survival rate was 86.3%, 81.1%, 73.0%, 50.3%, 47.8%, 7.8%, and 30.8% for Stage IB, IIA, IIB, IIIA, IIIB, IVA, and IVB respectively. Pattern of failure revealed 20.8% local recurrence, 18. 7% distant metastases, and 4% in both. The late complication rate Grade 3 and 4 (RTOG) for bowel and bladder combined was 7.0% with 1. 9% Grade 4. CONCLUSION: HDR brachytherapy used in this series produced pelvic control and survival rates comparable to other LDR series.

Adenocarcinoma↗
PubMed1995

Measurement of left ventricular ejection fraction from gated technetium-99m sestamibi myocardial images.

Left ventricular ejection fraction (LVEF) and single-photon emission tomographic (SPET) imaging of the myocardium can be performed after a single technetium-99m sestamibi (MIBI) injection. Sixty patients underwent SPET imaging with MIBI. Immediately after SPET acquisition ECG-gated 99mTc-MIBI perfusion images were acquired using 24 planar images per R-R interval. A new method for measurement of LVEF from the ECG-gated 99mTc-MIBI perfusion images was developed. To validate the method, LVEF derived from MIBI perfusion images was compared with that from conventional radionuclide ventriculography in all 60 patients. Forty patients had evidence of myocardial infarction and 20 had normal perfusion on MIBI imaging. There was no statistically significant difference between LVEF computed from 99mTc-MIBI perfusion images and that from radionuclide ventriculography (r = 0.7062, P < 0.001). There was little difference associated with the technique (intraobserver variability r = 0.9772, P < 0.001). Interobserver variability was also good (r = 0.8233, P < 0.001). LVEF from 99mTc-MIBI perfusion images can be obtained at the same time as assessment of myocardial perfusion and in the same orientation and metabolism of the myocardium, thereby permitting more accurate and realistic prognosis and diagnosis in patients with coronary artery disease.

Adult↗
PubMed1991

Thyroid function test in patient with acute-severe-nonthyroidal illnesses.

Patients with acute-severe-nonthyroidal illnesses had FT4 and T3 values below the normal range with the magnitude of change greater for T3 than FT4. Some patients had depressed and some had elevated TSH values. In the recovery phase, FT4 levels appeared to rise before T3 levels and TSH exhibited an exaggerated increase. These results are consistent with other studies which suggest that dysfunction of the hypothalamic-pituitary-thyroid axis may be associated with anomalous results for thyroid function test parameters in patients with acute-severe-nonthyroidal illnesses. This anomaly should be given due consideration when interpreting results of thyroid function test parameters in such patients.

Acute Disease↗