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V T Ivashkin

Publications and source records attributed to V T Ivashkin.

At least 109 records · Page 6Linked to original sources
PubMed1989

[General mechanisms of regulation of the activity of the stomach and pancreas in peptic ulcer and chronic pancreatitis].

Altogether 25 patients with peptic ulcer and 26 patients with chronic pancreatitis were examined for gastric and pancreatic secretion. Histamine dihydrochloride (0.008-0.024 mg/kg) was employed to stimulate gastric secretion whereas cholecystokinin (2U/kg/h) and calcium gluconate (16 mg/kg) were used to stimulate pancreatic secretion. Lidocain (1.2 mg/kg), a blocker of Ca2+-channels, and lithium hydroxybutyrate (12 mg/kg), a blocker of phosphatidylinositol transformations, were employed for suppression of gastric and pancreatic secretion. The content of HCl, pepsinogen, fucose, cAMP and cGMP was measured in gastric juice, that of bicarbonates, amylase, lipase, trypsin, cAMP and cGMP in pancreatic juice. It has been shown that mechanisms dependent on cAMP and on extra- and intracellular Ca2+ are involved in the initiation and maintenance of gastric and pancreatic secretion. However, the contribution of those mechanisms is different as applied to the regulation of ions and enzymes, on the one hand, and to various enzymes, on the other.

Adenylyl Cyclases↗
PubMed1988

[Randomized double-blind placebo-controlled study of drugs with anti-ulcer action and their use in associated pathology].

The effect of lithium preparations (lithium carbonate, lithium oxybutyrate), calcium channel blocking agents (verapamil, nifedipine), beta 2-adrenoagonist (salbutamol), cromolyn sodium and cimetidine on clinical efficacy and frequency of ulcer cicatrization was assessed in 201 patients (33 women, 168 men) with endoscopically verified stomach ulcer (52 patients) and duodenal ulcer (166 patients) during treatment for 4 weeks as compared to placebo and standard antiulcerative therapy (cholinolytics, antacids and reparents). All the tested drugs (excluding cromolyn sodium) significantly increased as compared to placebo the frequency of ulcer cicatrization (p less than 0.001 in the use of lithium preparations and cimetidine; p less than 0.01 in the use of salbutamol and verapamil; p less than 0.05 in the use of nifedipine). The effect of lithium preparations and cimetidine exceeded that of standard antiulcerative multimodality therapy.

Adult↗
PubMed1986

[Protein kinase activity and phosphorylation of endogenous proteins in the rat colonic mucosa during chemical carcinogenesis].

Treatment with a single dose of 21 mg/kg, of 1,2-dimethylhydrazine was followed by a significant decrease in the level of cAMP-dependent protein kinase (histone kinase) in rats' large bowel mucosa after 72 hrs. However, its level returned to basal value after 2 weeks, with casein kinase level remaining unchanged. Both carcinogen--induced tumors of the large bowel and adjacent mucosa showed a drop in protein (mol. wt.-50 kdalton) was enhanced in tumor considerably.

1,2-Dimethylhydrazine↗
PubMed1986

[Characteristics of histamine-sensitive adenyl cyclase from cells of the gastric mucosa of the rat].

Effects exerted by specific modifiers and ions on the adenylate cyclase activity of coarse membrane fractions of cells isolated from the rat gastric mucosa, were investigated. Fluoride ions cause 7-8-fold activation of the enzyme affecting neither the enzyme's affinity towards Mg2+-ATP, nor the cooperativeness of substrate binding. Cations Mg2+ and Mn2+ produce activating while Ca2+ inhibiting effects. GTP (10-5 M) enhances histamine activation of the enzyme and reduces maximal stimulating concentrations of histamine. GTP and Gpp(NH)p exert activating action on the enzyme causing 2- and 5-fold activation, resp. Adenosine suppresses the enzyme activity, the effect being potentiated by GTP. The plausible role of N-protein in the regulation of the enzyme activity is discussed.

Adenosine↗