PubMed Health⌕ Search

Biomedical subjects

V T Ivashkin

Publications and source records attributed to V T Ivashkin.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

[Reactive arthritis in young men in organized collectives].

The authors followed up 398 young males with reactive arthritis who had been admitted from organized collectives to hospital settings. Only one third of them could connect the development of reactive arthritis (ReA) with a survived infection: acute nasopharyngeal (26%), acute enterocolitis (7%), urethritis venerea (1%). Analysis of the clinical picture demonstrated that in case of indefinite ReA etiology together with the signs of myocardiac involvement one should not only exclude the presence of rheumatic attack but also to establish a possible relation of the disease with a prior survived poorly manifest intestinal infection. This fact should be taken into account if in the collectives, where from the patients were hospitalized, epidemic outbreaks of acute dysentery or cases of ReA and Reiter's disease etiologically connected with manifest intestinal infection were documented. Postenterocolitic origin of ReA could be suspected in patients with its continuous course and resistance to antiinflammatory therapy in whom arthralgia was preserved for a long time as was joint rigidity after a subsidence of joint changes due to the effect of acute inflammation. Besides, the detection of certain features of the articular syndrome and separate extraarticular signs characteristic of Reiter's disease and other conditions which comprised the group of seronegative HLA--B27-positive spondyloarthropathy are of high diagnostic value.

Adolescent↗
PubMedDate not supplied

[The role of Fas/FasL system in induction of hepatocyte apoptosis in chronic viral hepatitides].

The aim of the study was assessment of hepatocyte apoptosis depending on expression of Fas and FasL proteins by various liver cells in patients with chronic viral hepatitis B (CVHB) or chronic viral hepatitis C (CVHC). The symptoms of hepatocyte apoptosis were observed in 3 of 12 patients with CVHB and in 9 of 14 patients with CVHC, the proportion of apoptotic cells being 12-65%. Hepatocytes of healthy people and patients with hepatitis B or C express Fas protein in the cytoplasm diffusely, as granules or on cell membrane. In health, hepatocytes do not express FasL, but in CVH they do. The highest apoptosis was observed in Fas protein location as granules in cytoplasm or in their preferable location on the cell membrane. The severity of hepatocyte apoptosis in CVH directly correlated with FasL expression by the cells of the lymphoid-histiocytic infiltrate in the liver and inversely correlated with FasL expression by hepatocytes. Thus, a great part of hepatocytes in CVH are killed by the virus; Fas/FasL interaction is leading in damage to hepatocytes in CVH.

Adult↗
PubMedDate not supplied

[The role of apoptosis and proliferation of epitheliocytes in morphogenesis of Helicobacter pylori-associated gastritis].

77 patients with chronic Helicobacter gastritis verified endoscopically and exacerbation of duodenal ulcer were examined. H. pylori infection was identified by the rapid ureasa test (CLO-test) and Giemza staining. The patients received 7-day three-component therapy for eradication of H. pylori. Apoptosis and proliferation were studied in 16 patients in serial sections with the use of monoclonal antibodies. Eradication of H. pylori resulted in relief of inflammation and transformation of active gastritis in inactive one. H. pylori-associated gastritis is associated with activation of apoptosis of gastric mucosa epithelial cells and epitheliocytes proliferation. H. pylori eradication alters correlation between apoptosis of epitheliocytes and their proliferation: successful eradication of the infection decreases apoptosis, high proliferative activity of epitheliocytes persists reflecting enhancement of regeneration in gastric mucosa.

Amoxicillin↗
PubMedDate not supplied

[Adult respiratory distress syndrome in patients with infection].

A grave complication of sepsis is a respiratory distress in adult persons observed by the authors in 11.3% of the examinees. The syndrome of respiratory distress could develop in the presence of toxico-infectious (septic) shock or severe allergic immediate responses to the administration of certain drugs. The main approaches to the treatment of respiratory distress in adult septic patients turned to be glucocorticoids, heparin and recurrent sessions of hemosorption.

Adolescent↗
PubMedDate not supplied

[Protein kinase activity and cAMP level in gastric mucosa in non-neoplastic diseases].

Activity of cAMP-dependent and -independent protein kinases as well as content of cAMP were studied in biopsy preparations of gastric mucosal membranes obtained from patients with superficial gastritis, erosion, ulcer, adenomatous polyps and ulcer after treatment with laser irradiation. All the patterns studied were similar in preparations of adenomatous polyps and normal mucosal membrane. Activity of cAMP-independent protein kinases was increased under conditions of erosion, ulcer, gastroduodenal reflux and, especially, in ulcer tissue treated with laser. However, the ratio between cAMP-independent and -dependent phosphorylation was increased only in 50% of ulcerous diseases and in gastroduodenal reflux. The equilibrium of cAMP-dependent and -independent phosphorylation was not altered in the other impairments studied even though benign proliferation was stimulated using laser irradiation.

Aged↗
PubMedDate not supplied

[Significance of studies on cyclic nucleotide metabolism for practical medicine].

Based on the results of own studies and data available in literature the evidence is given on peculiarities of determination and estimation criteria for the content of cyclic nucleotides in people. Changes in the metabolism of these substances and their pathogenic role are considered for a large number of diseases. Pharmacotherapeutic aspects are described, in particular regulation of enzymes taking part in the metabolism of cyclic nucleotides. The data are presented pertaining to the clinical application of phosphodiesterase inhibitors in oncology, in diseases of the cardiovascular system, respiratory system and in neuropathology. Approaches to a selective modification of cyclic nucleotides metabolism in clinical practice are considered.

Animals↗