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V T Komarov

Publications and source records attributed to V T Komarov.

13 recordsLinked to original sources
PubMed2002

[Systemic lupus erythematosus and infectious endocarditis: similarities and differences].

AIM: To compare clinical laboratory data in systemic lupus erythematosus (SLE) and infectious endocarditis (IE) for analysis of similar and different features. MATERIAL AND METHODS: Clinical and laboratory findings were compared for 72 IE and 71 SLE patients examined for a decade. RESULTS: SLE and IE have the following common features: fever, pleurisy, pericarditis, hemorrhagic vasculitis, articular syndrome, renal disorders, anemia, rheumatoid factor (RF), cryoproteins (CP), elevated ESR, concentrations of circulating immune complexes (CIC), IgM. Characteristic of SLE were skin erythema, alopecia, Raynaud's syndrome, cerebrovasculitis, lymphadenopathy, pneumonitis, frequent articular lesions, leucopenia, high IgG levels, CP and antibodies to DNA. IE was characterized by thromboembolic complications, splenomegaly, pneumonia, high CIC and medium mass molecules concentration, high incidence rate of RF, positive hemoculture. CONCLUSION: In spite of known differences between IE and SLE, in some cases differential diagnosis is not easy to make. This leads to late etiopathogenetic therapy.

Diagnosis, Differential↗
PubMed2001

[Differential diagnosis of infectious and non-infectious thrombotic endocarditis].

The aim of the study was analysis of clinical and laboratory markers of non-infectious thrombotic endocarditis (NITE) to facilitate differential diagnosis with infectious endocarditis (IE). 20 NITE patients (8 males and 12 females, mean age 32.3 years) were included in the trial. They had primary antiphospholipid syndrome, secondary antiphospholipid syndrome in systemic lupus erythematosus, nodular polyarteritis, nonspecific aortic arteritis, paraneoplastic NITE in lung and stomach cancer. NITE was also diagnosed in patients with gout and ankylosing spondylarthritis. Clinical and laboratory findings allow to differentiate IE with NITE. The former is characterized by destructive valvular lesions registered at echo-CG, positive hemoculture and arterial embolism. As a rule, NITE is associated with antiphospholipid syndrome and manifests with arterial and venous thrombosis, thrombocytopenia, livedo and presence of antibodies to cardiolipins.

Adult↗
PubMed2000

[Current aspects of differentiated therapy of infectious endocarditis].

150 patients (90 males and 60 females, mean age 41.9 +/- 3.3 years) with infectious endocarditis (IE) were treated. 26.7 and 71.3% of the patients had primary and secondary IE, respectively. Clinical and laboratory manifestations of the variants indicate that each variant is associated with a certain clinicolaboratory syndrome: acute IE is associated with toxicoseptic syndrome, subacute--with immune unbalance, and thromboembolic complications, chronic--with immunocomplex visceral lesions. Different variants of the course predetermine different therapy. It is recommended to combined active antibacterial therapy with UV radiation of autoblood and hemosorption, hyperbaric oxygenation. Immunocorrective and efferent therapy hold promise in IE treatment. Glucocorticosteroids are effective in immunocomplex disorders.

Acute Disease↗
PubMed1999

[Infectious endocarditis: immune disorders, differentiated therapy].

AIM: Immunological assessment of variants of infectious endocarditis (IE) and design of differentiated approach to the disease therapy. MATERIALS AND METHODS: Of 150 patients treated (90 males and 60 females, mean age 41.9 +/- 3.3 years) 28.7% and 71.3% had primary and secondary endocarditis, respectively. With chronization of the process, there was a trend to growing immune unbalance (IU). RESULTS: The IU in IE patients manifested with leukocytosis changing for leukopenia, reduced absolute and relative number of lymphocytes, complement, T- and B-lymphocytes, growing content of CIC, IgM, rheumatoid factor and cryoproteins. CONCLUSION: Besides antibacterial therapy, IE patients need immunocorrective and efferent therapy.

Adjuvants, Immunologic↗
PubMed1998

[Differential diagnosis using artificial neuronal networks].

In order to rule out the effects of subjective factors and decrease the number of diagnostic errors, artificial neuron nets are proposed. By means of these nets the subjective and half-empirical heuristics are replaced with rational diagnostic information based on quantitative and logic analysis. The proposed method was used for deriving the decisive regularities ensuring the differential diagnosis between infective endocarditis and active rheumatic fever, infective endocarditis and systemic lupus erythematosus, and systemic lupus erythematosus and active rheumatic fever. Reliability of diagnostic tables representing the decisive regularities in the usual form is confirmed by clinical data.

Diagnosis, Computer-Assisted↗
PubMed1998

[The late results of dispensary observation in systemic lupus erythematosus].

AIM: Analysis of a 12-year follow-up SLE patients. MATERIALS AND METHODS: In the course of a 12-year follow-up of 104 SLE patients the following tests were made: biochemical (acute-phase blood proteins), immunological (circulating immune complexes, IgA, IgM, IgG, complement system, rheumatoid factor), functional (ECG, echoCG) and others. The authors also made correction of the maintenance therapy, determined indications for pulse-therapy with glucocorticosteroids and cytostatics, extracorporeal and hospital regimens. RESULTS: 10-year survival reached 63.4%. 21.5% of patients died. Main causes of death were acute disturbance of cerebral circulation, chronic renal failure, sepsis, acute myocardial infarction, autoimmune hemolytic anemia. Age under 26 years, male sex, renal lesion with nephrotic syndrome, skin lesions combined with cerebrovasculitis, polyserositis, absence of chemotherapy with glucocorticosteroids in doses up to 15 mg/day, cytostatics, of plasmapheresis or pulse-therapy indicated poor prognosis. SLE ran favourably more frequently in females, at age over 37, duration of the disease at least 10 years, glucocorticosteroids intake in doses 20 mg/day and higher. CONCLUSION: Follow-up is an important element in the complex of rehabilitation measures in SLE patients.

Acute Disease↗
PubMed1998

[The diagnosis and treatment of a secondary antiphospholipid syndrome in systemic lupus erythematosus].

AIM: The study of incidence of clinico-laboratory signs of antiphospholipid syndrome (APLS) and the results of its treatment in SLE. MATERIALS AND METHODS: Out of 120 patients with verified SLE, 13 (10.8%) had the signs of APLS. They underwent additional tests (platelet and lupus blood anticoagulant assays, assessment of immunity). RESULTS: APLS treatment consisted of suppression of antiphospholipid antibodies production by glucocorticosteroids and cytostatics, removal of antibodies by means of plasmapheresis, HBO therapy of thromboses and vascular defects. APLS in SLE frequently manifested with arterial thromboses, cerebrovasculitis, livedo, thrombocytopenia, lupus anticoagulant. CONCLUSION: Combined treatment of APLS in SLE improves the disease prognosis and prolongs life span.

Acute Disease↗