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Biomedical subjects

V T Pal'chun

Publications and source records attributed to V T Pal'chun.

At least 19 recordsLinked to original sources
PubMed2006

Modern cell technologies in the treatment of patients with tympanic membrane injury inflicted by mine explosion.

We evaluated the efficiency of transplantation of cultured human allofibroblasts onto tympanic membrane damaged by mine explosion in combination with Tampograss dressing (Paul Hartman). Transplantation of cultured human allofibroblasts was effective in 100% cases. Application of the film with fibroblasts onto perforation occupying from 1/4 to 1/2 of the tympanic membrane was more effective by 15% (by 59% in subtotal perforation) than tympanoplasty with amnion membrane. The mean duration of tympanic membrane restoration after spontaneous healing and amnionoplasty is virtually the same, while transplantation of allofibroblasts accelerated the process in comparison with other groups in perforation of any size; in subtotal defect the duration of tympanic membrane restoration was shorter by 14 +/- 1 days.

Accidents, Occupational↗
PubMed2006

[Treatment of scalping type nasal wounds by transplantation of cultured human allofibroblasts and a Grasolind neutral bandage].

The aim of the trial was evaluation of efficacy of human cultured allofibroblasts transplantation and novel bandage Grasolind neutral (Paul Hartmann, Germany) on the wound with a large defect of nasal soft tissues. Biopsy findings at different stages of healing of the wound confirmed high regenerative properties of human allofibroblasts. The latter promoted reestablishment of full-thickness graft in minimal scarring. After use of allofibroblasts physiological desquamation started 13 days earlier than in the control group. A novel interactive bandage Grasolind (Paul Hartman, Germany) produced a positive effect as it did not damage newly formed epidermal cells which stimulated regeneration.

Adult↗
PubMed2006

[Morphological radioautographic study of the palatine tonsils in chronic tonsillitis and healthy subjects].

A pilot morphological (radioautographic) study of healthy and affected palatine tonsils (in hypertrophy and toxic-allergic form of chronic tonsillitis) in children and adults has shown that intensity of biosynthetic processes (protein-synthetic -- RNA synthesis and proliferative activity -- DNA synthesis) in the cells of palatine tonsils and structural changes of their tissues depend on characteristics of pathological process. Microbial penetration into the tonsils with formation of an active focus of chronic infection is traced.

Adolescent↗
PubMed2006

[Acoustic and vestibular analysers in patients with mine explosion trauma].

The aim of the study was examination of the acoustic and vestibular functions in patients with mine explosion trauma. Acoustic and vestibular functions were studied in 27 patients (16 females and 11 males aged 19-66 years, mean age 37.2 +/- 4.12) admitted to the ENT clinic of Moscow city hospital N 1. All the patients had suffered from explosion in closed space. General clinical and complex otoneurological examinations were made including gustatory and olfactory investigations, studies of the facial skin sensitivity, nasal mucosa, corneal reflex, soft palate motility, audiometry and vestibulometry. The findings of the tests suggested the following conclusions: mine explosion damages hearing by impairment of both sound conduction (85.7%) and sound perception (61.2%), the latter suffering primarily at the cochlear level; damage to the cranial nerves V and XIII occurs at the level of the brain stem; mixed affection of the vestibular analyzer is seen primarily at the level of stem nuclei.

Adult↗
PubMed2005

[Correction of vestibular disorders in patients with otitis media purulenta chronica complicated by labyrinthitis].

A vestibulogic examination was made in 66 patients with otitis media purulenta chronica complicated with labyrinthitis. The patients were divided into two groups: group 1 received surgical treatment in an acute period of labyrinthitis, group 2 was treated conservatively with delayed operation. The patients were examined at admission, 2 weeks, 1, 3, 6 and 12 months after the treatment. It was found that compensation of the vestibular function in group 1 took place 6 months after temporal bone surgery, in group 2-9 months after delayed operation, i.e. 1 years after hospitalization.

Anti-Bacterial Agents↗
PubMed2005

[Principal criteria of evidence-based medicine].

Fundamental principles of evidence-based medicine are presented. Eight methodological constructions of evidence-based trials--from randomized controlled trials to case reports--are described. Such notions of evidence-based medicine as a confidence interval, an absolute risk and an absolute risk decrease, a relative risk and a relative risk decrease, odds ratio. It is stated that the code of research laws of evidence-based medicine underlies development of medical science and practice.

Evidence-Based Medicine↗
PubMed2005

[Myringoplasty and its effect on a vestibular function in patients with otitis media purulenta chronica (OMPC)].

A complex vestibulologic and audiologic examination was made in 25 patients with OMPC free of mesotympanitis before and after experimental myringoplasty with hen's egg amnion. The patients were divided into two groups depending on the presence of vestibular complaints. Partial or complete disappearance of subjective vestibular symptoms, reduced stimulation of the vestibular receptors (by 19%, on the average) were detected by experimental vestibular tests on the side of the affected ear. The asymmetry coefficient by labyrinth lowered by 31.1%, on the average.

Caloric Tests↗
PubMed2005

[Medical standards of out- and inpatient care in otorhinolaryngology].

To improve the quality of out- and inpatient care in otorhinolaryngology, the authors propose standard minimum of medical measures (preventive, diagnostic and therapeutic) which should be taken in each nosological entity of ENT pathology. It is emphasized that medical standards should be adjusted to the disease peculiarities, possible atypical course, etc., but the scope of diagnostic and therapeutic care should not be less than the standard list of measures. Deviation from the standards is a criterion of medical service imperfection.

Ambulatory Care↗
PubMed2005

[Chronic ronchopathy -- a nosological entity of pathological realization of upper airways obstruction].

A comprehensive examination and therapy of 90 snoring and apnea patients treated in an ENT clinic of the Russian State Medical University have established similar features of the diseases: pathological mechanisms, clinical manifestations, stages, outcome. This enables differential diagnosis and change of the syndromal diagnosis "pathological snoring" for a nosological one -- chronic ronchopathy. The term "ronchopathy" originates from a Greek word "ronhus"-- snoring; the term "chronic" means development of the disease due to chronic pathology of the upper airways and progression of a clinical symptom -- snoring.

Anthropometry↗
PubMed2005

[The role of rheological changes of blood and hemostasis in the development of acute neurosensory hypoacusis].

We studied blood rheology and hemostasis in patients with acute neurosensory hypoacusis (ANH) of different genesis to clarify correlations of these disorders with an ANH form. After examination 72 ANH patients (60 male and 12 female, age 19-68) were divided into three groups by ANH etiology: ANH of vascular genesis (group 1, 47 patients), ANH of viral genesis (group 2, 19 patients), ANH of traumatic genesis (group 3, 6 patients). Blood rheology was studied on viscosimeter Low-Shear 30 (Switzerland); hematocrit--on Autocrit (USA) centrifuge, platelet aggregation--on aggregometer Elvi 840 (Italy), coagulation--on coagulometer Tetra (Spain). Blood rheology and hemostasis in groups 2 and 3 were changed insignificantly, while in group 1 we registered disturbed microcirculation. Treatment with vasoactive drugs normalized both clinical picture of the disease and blood rheology, hemostasis. The highest activity was seen in use of the drugs tanakan and gincor fort.

Acute Disease↗
PubMed2005

[A comparative analysis of antibiotics efficacy in acute ENT infections].

The comparison of the efficacy of a number of antibacterial drugs in acute pyoinflammatory ENT diseases allowed the authors to recommend moxifloxacin as most effective in acute purulent ENT pathology. Moxifloxacin demonstrated its superiority in seeding (the highest sensitivity of the bacteria to this antibiotic), in the speed of development of the bactericidal action and in treatment results. The drug had no significant side effects.

Acute Disease↗
PubMed2005

[Problem of ENT hospital infection].

Five-year monitoring of microbial environment of the ENT department stated its relative qualitative persistence. Circulating in hospitals microbial strains have a direct influence on the course of the infectious process in the patients. Hospital infection in the ENT department replaces the initial pathogen for a polyresistant hospital pathogen or forms a persistent microbial association.

Air Microbiology↗
PubMed2005

[Psychosomatic status of patients with cochleovestibular disorders. Correction methods].

Psychosomatic status was studied in 106 patients aged 18-65 years with acute and chronic cochleovestibular disorders. Hearing problems, noise in the ears and vestibular disorders have a negative psychogenic effect in patients with cochleovestibulopathy. The majority of the patients need psychological and psychopharmacological care to relieve anxiety and form adequate attitude to the disease. Correction of psychosomatic disorders raises efficacy of the treatment of cochleovestibular diseases.

Adolescent↗
PubMed2004

[Bacterial contamination of the maxilla after radical surgical treatment].

Qualitative and quantitative examinations of the microflora in a postoperative cavity of 62 patients early after radical surgery on the maxilla with opening of the ethmoidal labyrinth have found that in spite of a noticeable antibacterial effect of the operation pyoinflammatory process in the wound is possible. Treatment basing on bacteriological findings is recommended.

Adult↗