[Hemodynamic changes in congenital heart defects with isometric myocardial hyperfunction].
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Biomedical subjects
Publications and source records attributed to V T Selivanenko.
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The authors examined and operated on five patients with congenital coronary arteriovenous fistulas. Patients suffering from this disease do not exhibit complaints typical of cardiopathy and the results of electrocardiographic and roentgenographic examination lack specific features. The presence of low systolic-diastolic murmur suggests a common arteriovenous coronary orifice and by means of coronarography it is possible to make a topical diagnosis.
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After performing 242 operations on patients with secondary atrial septal defects under conditions of moderate hypothermia, the authors studied the contractile capacity of the myocardium by means of long-term catheterization of the heart chambers in 56 patients. In 35 patients of this group intravital biopsy of the right ventricle was carried out. The bioptic material was subject to light and electron microscopy and histochemical examination. Considerable changes in intracardiac hemodynamics were revealed in patients with bacterial endocarditis. In such cases the diastole changes most sharply: the phase of isometric relaxation was prolonged, and there was a sharp rise in the maximum rate of intraventricular pressure decrease and in the relaxation index, which indicated to disorders of metabolic processes in the myocardium, conducive to the manifestation of myocardial insufficiency.
By means of the method of long-term catheterization of the cardiac chambers, the authors studied the dynamics of changes in the shape of the intraventricular pressure curves after correction of congenital and acquired heart diseases. Analysis revealed three main types of pressure curves. With the development of myocardial insufficiency under conditions of normal pressure, pressure curves characteristic of hypertension of pulmonary circulation were recorded in the right ventricle. The absence of abnormalities in pulmonary circulation made it possible to demonstrate a direct dependence of the shape of the curves on the contractile condition of the myocardium, which is valuable in the rapid diagnosis of myocardial insufficiency.
Operative treatment of isolated secondary interatrial septal defects in 236 patients is analysed. The results testify to the small degree of risk in suturing interatrial septal defects under conditions of moderate hypothermia. A study of central and intracardiac hemodynamics made it possible to reveal the development of acute pulmonary hypertension in some patients after the operation, which may be of a reflex character or a consequence of left ventricular insufficiency. A differential diagnosis and a therapeutic test are suggested for the differentiation and therapy of these conditions.
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Investigation of the central and intracardial hemodynamics was conducted in 60 patients with secondary defects of the interatrial septum. Using the method of long cardiac catheterization it was established that the systolic pressure in the right ventricle decreased and the final diastolic pressure increased which was an indication of functional insufficiency of the ventricle. This was confirmed by the reduction of work and potency of the right ventricle. Changes in the myocardial contractility in the nearest days after the operation were accompanied by a reduction in the maximum rate of the intraventricular pressure growth in the medium rate of ejaculation.
Studies of intracardiac haemodynamics were conducted in 30 patients subjected to valvuloplasty of the pulmonary artery valve. The method of continuous (for several days) right ventricle and pulmonary artery catheterization was employed. The isometric hyperfunction of the right ventricle was found to persist following the elimination of pulmonary valve stenosis. Myocardial insufficiency then develops that requires intensive cardiac therapy.
The intracardiac and central hemodynamics was studied in patients with secondary atrial septal defects pre- and post-operatively. After surgery continuous catheterization of the heart chambers was employed which permitted to receive the information directly from the right ventricle. Following a statistical processing of the obtained data, regression lines were formed that reflected the relationship between the work-load of the right ventricle and the end-distolic pressure. It was demonstrated that the development of latent myocardial insufficiency requires certain limitations in the amount of the infused fluids and enhancement of cardiac therapy.
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