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Biomedical subjects

V Tatić

Publications and source records attributed to V Tatić.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Histopathological evaluation of the carbon fibers application for the substitution of the anterior cruciate ligament--an experimental study on dogs.

The application of allograft-carbon fibers on the experimental group of 15 dogs (German Shepherd race) was histopathologically investigated after the artificial lesion of anterior cruciate ligament (ACL). In definite time intervals (1, 2, 4, 6 months) pathoanatomic and histopathologic findings were analyzed and the proliferation of new connective tissue of predominantly elastic type, between carbon fibers was observed. Beside the lymphocyte infiltration around torn carbon fibers giant cells of a foreign body type were found, and on the surface the epithelium similar to synovial was observed. It was concluded that carbon fibers could not be considered as the ideal artificial ligament.

Animals↗
PubMedDate not supplied

[Immediate results of surgical treatment of intracardiac myxomas in 45 patients].

Between 1961 and 1992, 45 patients with intracardiac myxomas localised in the left ventricle--40 (89%) and in the right ventricle--5 (11%) were operated on. There were 27 women and 18 men, aged 15-63, mean age, 46.5 years. Three patients were asymptomatic while in other dominated different degree of malfunction of the corresponding atrioventricular valve, mainly with dominant symptoms and signs of stenosis. In 5 patients (11%) myxoma of the left atrium was in question together with systemic embolization. The diagnosis was established both by invasive and noninvasive methods and the method of choice, very reliable and easy, has proved to be echocardiography. All patients were operated on with the use of the total cardiopulmonary bypass and induced heart arrest. The histologic verification of all excised myxomas was performed. Three early deaths occurred (6.6%), while in other patients no postoperative complications developed. It has been concluded that echocardiography is very safe diagnostic procedure and results of surgical treatment are very good.

Adolescent↗
PubMedDate not supplied

[Hemangiopericytoma of the lungs].

Six patients, three women and 3 men with lung hemangiopericytoma treated at the Military Medical Academy in the period 1971-1991 are reported. The youngest patient was 20 years, the oldest 69 years. Surgical treatment was performed in all patients, 3 lobectomies, one bilobectomy, one wedge resection and one extirpation. Multiple hemangiopericytoma was found in one patient which consisted of three separate tumours in the right lung. The other had solitary lesions. Malignant hemangiopericytoma, was found in 4 patients, one of them had metastases in the mediastinal lymphatic glands. Four patients are alive and are under control for nine years in the average without signs of recurrence.

Adult↗
PubMedDate not supplied

[Anatomic characteristics and clinical signs of congenital anomalies in the circle of Willis].

Anatomical characteristics and clinical importance of congenital anomalies of cerebral arteries were examined based on the results obtained by dissection of the circle of Willis blood vessels of 70 native cadaveric brains. Anomalies were most frequently found in posterior communicant artery and their most frequent type was hypoplasia of the blood vessel. Multiple anomalies of the circle of Willis were found in 3 cadavers. Premortal neurological symptomatology (PNS) existed in 5 cadavers. There was no significant difference in PNS occurrence at autopsy in cases with or without anomalies. Association of aneurisms with anomalies of the circle of Willis was found in two cases, but it was not significant in comparison to the control group with no anomalies.

Circle of Willis↗
PubMedDate not supplied

The use of autografts and synthetic carbon fibers in reconstruction of the anterior cruciate ligament--an experimental study on dogs.

Biological characteristics and strength of the anterior cruciate ligament (ACL) after replacement by an artificial carbon fibers ligament--(group 1) and autograft--fascia lata (group 2) were investigated. These two methods were compared in four periods of time by means of clinical course, laboratory parameters, histopathological analysis and biomechanical testing on an Instron apparatus. Strength of neoligament in both examined groups has never achieved the strength of natural, unaffected ACL, and there was no significant difference between two observed groups in relation to clinical and laboratory parameters. Histopathological examination showed the presence of ingrowing of the connective tissue between carbon fibers, but in bone tunnels inside the fibers there was no ingrowing between bone trabeculae. In the group 2, collagenic fibers of the fascia lata were substituted with predominantly elastic connective tissue, with epithelium, similar to synovial, on the surface. No absolute superiority of carbon fibers to fascia lata as a substituent of the anterior cruciate ligament of a dog knee, as an experimental analog, was proved in this study.

Animals↗
PubMedDate not supplied

Morphological analysis of saphenous vein used for aortocoronary graft.

Histological, histochemical, immunohistochemical and ultrastructural analyses of 120 saphenous veins (of 120 patients) prepared for aortocoronary graft, revealed in 57 cases lesser or larger morphological changes, such as endothelial damage, hyperplasia of t. intima, or t. media, and fibrosis of t. adventitia that could be the result of postoperative complications (thrombosis of the graft lumen, or its occlusion due to progressive hyperplasia of t. intima). The analyses have proved significantly increased number of smooth muscle cells and fibroblasts in t. intima of the damaged veins in relation to t. media, contrary to the findings in normal veins, and it was suggested that these smooth muscle cells in the damaged veins migrated from t. media to t. intima causing hyperplasia, as was confirmed by histochemical, immunohistochemical and ultrastructural findings. Since in 57 of 120 analyzed veins morphological changes were found which developed before the implantation of vein and which could compromise the vein function as the aortocoronary graft and cause severe postoperative complications, forming of vein banks is recommended from the chosen donors to avoid vein implantation with the already existent morphological changes, that could be proven by their immediate histological examination.

Adult↗