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Biomedical subjects

V Tchertkoff

Publications and source records attributed to V Tchertkoff.

At least 37 records · Page 2Linked to original sources
PubMed1980

Penile vascular cushions and erection.

Penile intimal cushions in the arteries and veins of five adults and one newborn were studied. In adults, they were present in approximately one-third of the muscular vessels seen on a single cross-section. No cushions were found in the newborn penis. We postulate that cushions play only a passive role in erection. Theories as to their pathogenesis are presented and the concept of linear stress as an adaptive agency is favored.

Adolescent↗
PubMed1978

Renal lesions in chronic pancreatitis.

Many patients with chronic pancreatitis (CP), even in the absence of intrinsic renal disease, are found to have abnormal urine, with persistent proteinuria, cylindruria, microhematuria and leukocyturia. The kidneys of 12 necropsy cases with CP showed mild to moderate arterial and arteriolar nephrosclerosis and no other significant changes. Renal biopsies were performed in 10 patients with CP without evidence of systemic disease or intrinsic renal disease, but with persistent urinary abnormalities. By light microscopy, mild arterial and arteriolar nephrosclerosis was present in 5 instances. In 1 patient, evidence of the reparative phase of acute tubular necrosis was noted. In 5 biopsies, electron microscopy revealed minimal to mild increase in mesangial matrix. Mild thickening of the glomerular basement membrane (GBM) was found in three instances but there was no clear-cut evidence of diabetic glomerulosclerosis. The presence of subendothelial electron-lucent material in 3 cases suggests the possibility of previous subclinical episodes of intravascular coagulation. The most consistent finding was the presence of lipid material in the cytoplasm of glomerular and tubular cells. The renal lesions associated with CP are mild, nonspecific and nonprogressive. Various pathogenetic factors can be invoked to account for their presence and for the urinary abnormalities found in patients with CP.

Adolescent↗
PubMed1977

Adenocarcinoma of the rete testis: a review of the literature and presentation of a case with associated asbestosis.

Although scattered reports of adenocarcinoma of the rete testis have previously appeared and criteria for the diagnosis of this tumor have been defined, previous cases have not been described in sufficient detail to provide an organized account of the nature and behavior of this neoplasm. The present report describes a case followed to autopsy and provides conclusive evidence that it is of rete testis origin. Previously reported cases of rete testis carcinoma are reviewed and the salient features summarized, showing that the tumor has a definite clinical and histologic pattern and that the prognosis appears poor. The present case occurred in a patient with severe pulmonary asbestosis. This association is unique, and its significance remains speculative.

Aged↗
PubMed1977

Bartter's syndrome: an overview.

Bartter's syndrome, which is characterized by hypokalemic hypochloremic alkalosis, renal juxtaglomerular hyperplasia, elevated renin and aldosterone, and normal or low blood pressure, has been ascribed to a variety of etiologies. Most recently, the prostaglandins have been in the forefront of the pathophysiologic discussion. Two cases with appropriate renal biopsies are reviewed, as are the clinicopathologic pathways. It is important that strict criteria be applied, and confirmation by renal biopsy is urged.

Adult↗
PubMed1975

Membranous nephropathy: an overview.

Membranous nephropathy (MN) accounts for about 20 percent of cases of the nephrotic syndrome. The importance of renal biopsy in establishing the diagnosis is emphasized. In the great majority of MN patients, no etiologic factor can be discerned. In a significant minority, MN appears to be a manifestation of sarcoidosis, diabetes, lupus, syphilis, malaria, or toxicity from heavy metals or drugs. In some cases the "cause" is neoplasia (including lymphoma) or a viral infection. Massive proteinuria, hypoproteinemia and edema are the principal manifestations of MN, finally resulting in renal failure. Treatment consists chiefly of diet and diuretic drugs. In the more pronounced cases, corticosteroids may have a favorable effect and in very resistant cases, cyclophosphamide is indicated. Judicious use of these modalities if often associated with the diminution or disappearance of the clinical signs of MN.

Adult↗
PubMed1975

Membranous glomerulopathy in a patient with sarcoidosis.

We describe a case of membranous nephropathy in a patient with pulmonary, splenic and hepatic sarcoidosis. The patient was asymptomatic, and edema was absent notwithstanding the proteinuria (over 8.0 gm/100 ml daily). Prednisone cleared the pulmonary and splenic complications, but the proteinuria, although diminished, persisted. Adjunctive therapy with cyclophosphamide caused further diminishment of the proteinuria. We have reviewed the relationship between the nephropathy and the sarcoidosis and suggest that a causal relationship exists between the two diseases.

Adult↗