Thymo-bursal reactions under the immunosuppressive action of cyclophosphamide.
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Biomedical subjects
Publications and source records attributed to V Toma.
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Thymus responses in tumoral-bearing hosts can illustrate two moments of immunological crisis corresponding to the tumour intake and its metastazic spread. These data are in accord with Burnet's (3) hypothesis that cancer is due to the inability of immunological surveillance mechanisms to reject somatic cells bearing neoplastic mutation.
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Authors in the literature are unanimous in considering type A personality as an individual characteristic susceptible to cardiovascular risk. The latter, in its turn, is regarded, after H. J. Eysenck [4], as an association of the scores of extroversion and neurosis. Starting from this assumption, we set out to outline a profile of the cardiovascular patient using the "Eysenck" questionnaire. The study population included 126 industrial workers compared to a matching control set. The resulting profile displayed neurotic components within an ego perpetually frustrated in its needs of well-being, emotional satisfaction and rewarding social relations (-1,dark blue, Lüscher colour test in its shortened variant). Stress and introversion foster neuroticism and encourage the ego in its compulsive quest for autonomy, "eccentric" behaviour in actual situations and egocentric attitudes in reserve. Findings suggest that the "H. J. Eysenck" test for introversion-extroversion and neuroticism, as well as the Lüscher colour test (the shortened variant) are likely to be useful predictive tools in cardiovascular disease.
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The total (T) proteic (P) and non proteic (NP)-SH groups in the thymus of male Wistar rats were assayed and the P/NP ratio calculated. Hydrocortisone was administered to the experimental groups as follows: 1, 6, 15 and 45 mg/100 g body weight. Up to a dose of 6 mg HC, the thiol groups decrease progressively, especially the NP groups. At higher doses, the first two--SH groups (T and P) continue to decrease quantitatively, whereas the NP thiol groups notably increase. In the author's opinion, this is due to the exacerbating stages encountered during stress.