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V Trapanotto

Publications and source records attributed to V Trapanotto.

5 recordsLinked to original sources
PubMed1999

Ablation of renal tumors in a rabbit model with interstitial saline-augmented radiofrequency energy: preliminary report of a new technology.

OBJECTIVES: To evaluate the efficacy of interstitial saline radiofrequency energy for reproducibly ablating nonmalignant (control) and malignant (the VX-2 tumor) renal tissue in a rabbit model, and to determine the ability of conventional gray-scale and power sonography to image the tumor and ablative process in real time before, during, and after treatment. METHODS: The VX-2 tumor was implanted beneath the renal capsule in 18 rabbit kidneys. Twelve days after implantation, 50 W of 500-kHz radiofrequency energy was delivered into the surgically externalized renal tumor and contralateral control kidney for 30 or 45-second treatment intervals using an interstitial saline-augmented radiofrequency probe (the virtual electrode). Localization of the tumor and response to treatment were imaged with gray-scale and power Doppler ultrasonography. The effect of radiofrequency and extent of the destructive process on benign and malignant renal tissue were evaluated histologically. RESULTS: Mean tumor size was 1.3 x 0.7 cm. Both 30 and 45-second treatment intervals provided marked tissue/tumor ablation. Gross anatomic and histologic analysis showed time-dependent ablated lesions averaging 1.4+/-0.3 x 1.0+/-0.3 cm (30-second treatment) and 1.8+/-0.4 x 1.5+/-0.3 cm (45-second treatment), with clear demarcation of the surrounding parenchyma. Conventional gray-scale sonography allowed visualization of the ablative process, and power Doppler ultrasound demonstrated changes in the vascular pattern of the tumor both before and after ablation. No immediate treatment-related complications were observed. CONCLUSIONS: These preliminary studies in a rabbit model demonstrate the feasibility of using the interstitial saline-augmented electrode to ablate small renal tumors and the ability to simultaneously visualize the ablative process using real-time ultrasonography. This technology may have the potential to treat small renal tumors in a minimally invasive manner in the clinical setting.

Animals↗
PubMed1999

Three-dimensional US of the prostate: early experience.

PURPOSE: To assess the feasibility of using a three-dimensional (3D) endorectal transducer at ultrasonography (US) in the prostate gland in a clinical setting. MATERIALS AND METHODS: Sixteen patients underwent 3D imaging of the prostate gland with a 3D endorectal probe following conventional two-dimensional (2D) US and prior to prostatic biopsy. Image acquisition was performed as a volume of data with nearly immediate reconstruction and simultaneous display of sectional anatomy in three orthogonal planes--sagittal plane, transverse or coronal plane, or any arbitrary oblique plane. Images were evaluated for presence of focal lesions, glandular volume, visualization of lateral and anterior portions of the gland, and extraglandular extension of tumor. RESULTS: Three-dimensional US allowed better visualization of the gland and focal lesions, especially on the coronally reconstructed images, which were judged superior to the sagittally or transversely reconstructed images for interpretation in 50% of the patients. Prostatic volumes obtained from 3D US were consistently smaller than volumes obtained from 2D US (20% difference, P = .006). Three-dimensional US was superior to 2D US in depicting tumor presence (nine of 10 right hemispheres, three of eight left hemispheres) and extraglandular extent of disease (three of five hemispheres). CONCLUSION: Three-dimensional endorectal prostatic US appears to be clinically feasible and easy to perform. Added anatomic information from the coronal plane may allow better depiction of tumors and extraglandular spread than is possible with current 2D techniques.

Endosonography↗
PubMed1994

Three-dimensional US: preliminary clinical experience.

PURPOSE: To evaluate applications of three-dimensional (3D) ultrasound (US) in a clinical setting. MATERIALS AND METHODS: Sixty-two patients were examined with experimental 3D US transducers coupled to a commercially available US unit and a computer workstation. Images were acquired in either the sagittal or transverse plane and were reconstructed in two orthogonal planes, transverse and sagittal; the C-plane, parallel to the transducer surface; and a volumetric rotational transparency display. RESULTS: A variety of normal and diseased abdominal and superficial organs and selected fetal anatomy, and pathologic conditions were imaged. 3D US allowed display of anatomy and pathologic conditions in planes usually not possible with conventional two-dimensional (2D) US. CONCLUSION: Preliminary data suggest that 3D US may become a valuable clinical tool and adjunct to 2D US. 3D US allows depiction of normal and abnormal structures in previously unattainable planes, thus facilitating diagnosis and increasing operator diagnostic confidence.

Abdomen↗