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Biomedical subjects

V V Anikin

Publications and source records attributed to V V Anikin.

At least 19 recordsLinked to original sources
PubMed1992

[Characteristics of the dynamics of rapid changes in blood phosphoinositides in patients with alcoholic heart diseases].

A total of 42 patients who had been abusing alcoholic beverages during different periods and 12 healthy individuals were examined. Their intracardiac hemodynamic parameters were evaluated by echocardiography and rapid changes in inositol-containing blood lipids were determined by thin-layer flow chromatography. The patients showed significantly reduced contractility of the left ventricle, its wall hypertrophy and greater cavity dimensions. These abnormalities were more pronounced in patients with an over 10-year history. Biochemical studies revealed a time course of rapid changes in inositol-containing lipids in patients, which showed more fluctuations in the content of phosphoinositides and their lower baseline and final levels and differed from that in healthy persons. It was stressed that the changes in inositol-containing lipids were also related to the duration of alcohol abuse and they reflected the mechanisms of the toxic action of ethanol on the myocardium, which might be useful in the assessment of the severity of cardiovascular events in alcoholism.

Adult↗
PubMed1991

[The dynamics of the blood level of phosphatidylinositol in patients with myocardial infarction].

Phospholipids, particularly inositol-containing ones, that serve as secondary messengers and bioregulators of fundamental biochemical processes, essentially contribute to the origination of cardiovascular diseases. These compounds are highly labile and the data on their levels in the blood and its components in various cardiovascular conditions are contradictory. This may be explained by the fact that phosphatidylinositol levels change immediately after blood collection. Therefore the authors found it interesting to investigate the time course of this phospholipid levels, that may to a certain measure reflect the pattern of the metabolic disorders present in this case. They suggest a method of multiple measurements of phosphatidylinositol levels, carried out in short intervals, this yielding additional data on the function of biologic membranes, that may be useful in the diagnosis of coronary disease and assessment of the efficacy of treatment of this condition.

Adult↗
PubMed1991

[The dynamic change in the content of total lipids in myocardial infarct patients].

The dynamics of the content of total lipids (cholesterol and cholesterol esters) was studied in patients with acute large-focal uncomplicated myocardial infarction in different disease periods. Rapid quantitative changes that occur in the content of cholesterol and its esters in the test groups were established to be characterized by marked specificity and by the form of its own in different disease periods (in the acute period--days 2-5 and on day 15--the health status stabilization). It is advisable that the characteristics of the dynamics of rapid reversible changes in the content of total lipids may be used for estimating the status gravity of patients with uncomplicated large-focal myocardial infarction.

Adult↗
PubMed1991

[Characteristics of the changes in echocardiographic indicators of the electric cardiac pacing in alcoholics].

To specify cardiovascular function in alcoholics (74 males capable for work by their age) of stage II, they under went M-mode ECG at the height of the rhythm induced by transesophageal pacing. One third of the examinees demonstrated worsening of the left ventricular contractility evident from reduced ejection fraction (by 17.1%) and shorter anteroposterior size of the left ventricle (diminution by 18.1%). Paradoxical movement of the interventricular septum in the systole emerged in one fifth of the patients at the height of the stimulation. It is believed important to identify a group of patients with initially abnormal intracardiac hemodynamics (13.6%). They suffered further deterioration of myocardial contractility. The study of ECG findings at the height of atrial stimulation detects latent alcoholic myocardiodystrophy.

Adolescent↗
PubMed1990

[Clinico-functional criteria of work capacity and the characteristics of professional rehabilitation of patients with stenocardia].

Proceeding from the experience gained in the medical examination of persistent working ability loss, which was based on the results of bicycle ergometric studies in 383 patients with stable angina, the authors developed clinicofunctional criteria allowing the practitioner to establish the degree of physical working capacity limitation (poor, satisfactory, good). The validity of the criteria was confirmed by coronary angiographic evidence and long-term observation results. Over 3 years of the follow-up, 28% of the patients who had been group II invalids and 7% of the Group III died among those recorded by the medical-and-labour examination commission that used the criteria described above. All the individuals who had been regarded as being able to work survived. The occupational activities adequate to the fitness of patients with angina promote the development of adaptive mechanisms, mobilize the functional reserve of the blood circulatory apparatus, enhance their physical performance. It has been concluded that the efficacy of the medical-and-labour examination in angina is determined by an accurate assessment of its severity and closely associated with the application of bicycle ergometry.

Adult↗
PubMed1990

[Use of dynamic transesophageal electric stimulation of the heart in patients with functional disorders of the sinoatrial node].

Transesophageal pacing used for sinus dysfunction detection in 103 patients has been assessed for informative appropriateness in design of the attendance policy and efficacy of outpatient chemotherapy. The response control by electrophysiological monitoring was performed in 22 patients with true sick sinus syndrome (group 1) and 27 ones with sinus dysfunction (group 2). The rest patients were not controlled objectively. Transesophageal pacing of 5 group 1 patients brought about indications for surgical treatment. For 8 patients the follow-up revealed evolution of the sinus vegetative dysfunction into organic lesion which required surgical intervention in one case. The effect of chemotherapy with sympathomimetic drugs in adequate doses tended to reduction with increasing duration of the follow-up. In those with true sick sinus syndrome this process ran more actively. Long-term chemotherapy for sinus dysfunction is found effective as it warrants appreciable improvement of sinoatrial conduction, outpatient therapy control by dynamic transesophageal pacing is objective and can be recommended as adequate.

Adult↗
PubMed1990

[Various diagnostic criteria for abnormal signs of the artificial pacemaker examined by transesophageal electric stimulation of the left atrium].

Forty eight patients with abnormal sinus node were subjected to transesophageal electric stimulation (TES) of the left atrium to assess the length of poststimulation pauses (PSP) and the first 5 spontaneous sinus cycles after TES cessation. Higher values of PSP were found in patients with the sick sinus syndrome than in healthy subjects. Transition of TES to sinus rhythm is of practical value. In patients with the sick sinus syndrome, the first sinus contraction was shorter by 4.6% than the last PSP after TES (the respective value being 16.6% in healthy subjects), whereas this parameter was 20.9% (p less than 0.01) in patients with autonomic dysfunction of the sinus node. Hence, the functional potentialities of sinus node activity recovery are inconclusive with its various abnormalities, which may serve as one of differential diagnostic criteria for organic or functional pathology of a cardiac pacemaker.

Adult↗
PubMed1990

[Characteristics of the status of autonomic innervation and of the functioning of the heart conduction system in alcoholism].

As many as 71 men fit for work (aged 32.6 years on the average) suffering from stage II alcoholism were examined with the aid of variation pulsimetry. The findings obtained were compared with the data of electrophysiological exploration of the heart by transesophageal pacing. In the majority of the patients (80.2% of cases), the changes in vegetative homeostasis manifested themselves primarily by activation of the sympathetic nervous system and combined both with a noticeable decrease of sinus node automatism function and an appreciable deterioration of conduction in the sinoatrial zone and atrioventricular junction. In addition, sinus node automatism function and sinoatrial conduction were inhibited to a greater degree in sympatheticotonia whereas deterioration of antegrade impulse conduction in the atrioventricular junction manifested itself mostly in association with predominant vagus influences. It is emphasized that in patients with alcoholism, sympatheticotonia was attended by different impairments of the heart rhythm in half of the cases.

Adolescent↗
PubMed1988

[Results of a long-term follow-up of exercise test indicators in patients with various courses of stenocardia].

The study was undertaken to examine the natural history of stable angina in 295 patients who had been followed up for an average of 5.4 years. The results showed that among them the survival rate was 77%. Out of 217 survivors, 47.5% exhibited no changes in the manifestations of coronary heart disease, only 7.8% showed improvement and increase in exercise performance, in 44.7%, their status became worse as manifested by more frequent anginal attacks and significantly diminished exercise tolerance; 3.2% developed congestive heart failure, there were marked ECG cardiac arrhythmias or scarry changes due to sustained myocardial infarction in 3.2% and 11.1%, respectively.

Adult↗