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V V Bezrukov

Publications and source records attributed to V V Bezrukov.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Correlative links between superoxide dismutase, catalase and glutathione peroxidase activities in mouse liver].

Qualitative and quantitative differences in correlative and regressive links between superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase were assessed in the mice liver by two- and three-dimensional statistical methods. Paired linear correlation analysis indicated SOD-CAT tandem as the correlatively acting enzymatic pair. Three-dimensional analysis revealed uniform response surfaces which exhibited higher activities at disproportional values of the other two and lower activities at proportional activities of the other two enzymes. The direct effect of the enzymes on each other was positive [table: see text] while the effect of their product was always negative.

Animals↗
PubMedDate not supplied

[Effect of adrenergic and cholinergic blocking agents on the intensity of RNA and protein biosynthesis in the liver of adult and old rats].

The uptake of labelled precursors of RNA and protein and their incorporation into corresponding macromolecules were studied in the liver of adult and old rats after pharmacological blockade of the adreno- and cholinoreceptors. The data obtained suggest direct neural regulation of transcription and translation intensity as well as the weakening of these mechanisms in aging.

Aging↗
PubMedDate not supplied

[Synthesis of RNA fractions in rat liver during single and multiple stimulation of the hypothalamus].

Specific radioactivity of RNA from rat liver tissue, labelled with 14C-orotic acid and fractionated using thermic phenol method, was altered dissimilarly. In single stimulation of hypothalamus the specific radioactivity of nuclear RNA was increased in RNA-40 degrees fraction than in RNA-55 degrees and RNA-63 degrees ones. A decrease in synthesis of nuclear RNA fractions followed the phase of activation in repeated stimulation of hypothalamus. The distinct increase in specific radioactivity was observed in cytoplasmic RNA (RNA-4 degrees) both in single and repeated stimulation of hypothalamus. The stimulating effect of the prolonged hypothalamus irritation on synthesis of the RNA fractions and on activity of glucose-6-phosphatase and fructose-1,6-diphosphatase disappeared more rapidly than this effect in long-term administration of hydrocortisone. The data obtained suggest that sensitivity of tissue-targets to prolonged hormonal stimulation is distinctly higher than the ability of hypothalamus to activate the synthesis of RNA and enzymatic proteins.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Age-related properties of inductive synthesis of glucose-6-phosphatase, fructose-1,6-diphosphatase, tyrosine aminotransferase and tryptophan pyrrolase in hypothalamus stimulation].

In aged rats electrostimulation of hypothalamus caused less distinct induction of the enzymes in liver tissue, kidney and spleen as compared with the adult animals. The activation of the total RNA synthesis (actinomycin D and olivomycin) eliminated the alterations in the enzymatic activities, caused by the stimulation of hypothalamus. Effect of adrenalectomy and administration of ACTH suggested that the influence of the hypothalamus stimulation on induction of the enzymes studied was realized through the system hypophysis -- adrenal cortex. In the aged animals activation of adrenal cortex was less distinct when the stimulation of hypothalamus was carried out. The alterations in hypothalamic regulation of the enzyme induction could be an important mechanism in regulation of adaptive reactions in aged organisms.

Aging↗
PubMedDate not supplied

[Endocrine changes in experimental hypothalamic obesity in rats].

Hypothalamic adiposity in rats developing in bilateral electrolytic damage of the ventromedial hypothalamus is characterized by a marked activation of the insular apparatus of the pancreas, enhanced biosynthesis and secretion of the somatotropin by the hypophysis, reduction of the thyrotropic function of the hypophysis and functional activity of the thyroid gland with a disturbed metabolism of the thyroid hormones in target tissues, unchanged or reduced glucocorticoid function of the adrenal glands, intensified lipogenesis, reduction of the content of cyclic 3',5'-adenosinmonophosphate in a number of organs and tissues.

Animals↗
PubMedDate not supplied

[Functional and ultrastructural changes in the adenohypophysis in obesity].

The indices of some tropic adenohypophyseal functions of obese patients were compared with ultrastructural reaction of the adequate adenocytes of rats with experimental hypothalamic obesity. It was shown that in obesity significant functional and structural changes occur in adenohypophyseal cells, their extent being considerably associated with the excessive body mass. In pronounced obesity, a decrease in somato- and thyrotropic- and an increase in gonado- and corticotropic adenohypophyseal functions are seen, manifesting in ultrastructural changes of appropriate adenocytes. The results obtained allow a conclusion, that one of the mechanisms of obesity development is the changed secretory potency of adenohypophyseal cells, producing hormones, which exert a substantial influence upon lipogenesis and lipolysis processes.

Adolescent↗
PubMedDate not supplied

[Functional and morphological changes in the islands of Langerhans in obesity].

Functional changes in pancreatic islets seen in obese patients were compared with morphological and ultrastructural alterations in islet cells in rats during varying time of the experimental hypothalamic obesity development. The blood level of insulin and C-peptide in obese patients increases with the disease severity, but functional B-cell reserves tend to decrease as shown by glucose tolerance test. Reduction in glucagon release is seen in insulin hypoglycemia. A fall in B cell reserves is caused by their functional overtension, destruction and replacement of the pancreatic parenchyma by the connective tissue. The main morphological reason for glucagon release lowering in patients with pronounced obesity is reduction of A cell number. An elevation of somatostatin level in the blood of obese patients with a simultaneous decrease in D cell number in pancreatic islets of experimental animals indicates that this rise is stipulated by intensified hypothalamic somatostatin secretion.

Animals↗