PubMed Health⌕ Search

Biomedical subjects

V V Borisov

Publications and source records attributed to V V Borisov.

49 records · Page 3Linked to original sources

[Conformation of aspartate aminotransferase in crystals].

X-ray study of chicken cytosolic aspartate aminotransferase revealed conformational changes in the protein of two kinds: (1) a shift of the small domain adjacent to substrate-binding area due to interaction of the protein with two carboxyl groups of substrate and (2) a change in inclination of the coenzyme plane due to replacement of C = N bond of the coenzyme with Lys-258 by C = N bond with a substrate. An asymmetry in subunit behaviour is observed in both cases: the domain is shifted in one subunit and the coenzyme is rotated in other. Substrate-binding properties of each subunit are strictly dependent on the protein conformation in substrate-binding area.

Animals↗

[Inferior venacavography in a kidney tumor].

Indications to inferior cavography were detailed after examination and treatment of 745 patients with renal carcinoma (vena cava inferior was involved in 108 of them). Tumor invasion of the renal vein on the right and left, right kidney tumor T3 may displace and press vena cava inferior. Metastases to the lymph nodes increased the aortocaval space.

Diagnosis, Differential↗