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Biomedical subjects

V V Chalenko

Publications and source records attributed to V V Chalenko.

At least 19 recordsLinked to original sources
PubMed2002

[Extracorporeal methods of hemocorrection in the combined treatment of patients with purulent surgical infection of soft tissues complicated by sepsis].

Extracorporeal methods of hemosorption and detoxication were used in treatment of 293 patients with purulent surgical infection of soft tissues complicated by sepsis. In 35 patients with the same nosology the methods in question were not employed. An analysis of the clinical observations has shown that lethality in the main group was reduced to 23.6%. The sorption technologies were shown to be most effective for normalization of leukocytosis, lekocytic index of intoxication, middle mass molecules in this group of patients.

Adult↗
PubMed2001

[Effects of extracorporeal hemo-correction on lipid peroxidation in patients in critical states].

The article presents an analysis of immediate influence of extracorporeal hemocorrection upon the indices of lipid peroxidation in resuscitation patients of a surgical profile. It was found that hemosorption, ultrafiltration and their combination exert a moderate detoxicating effect on lipid peroxidation products. The detoxicating effect of plasmapheresis is negligible. Hemosorption and ultrafiltration fail to influence the mechanisms of antioxidant defense, plasmapheresis eliminates the antioxidant enzymes from blood plasma, and the methods of quantum therapy stimulate the activity of superoxide dismutase.

Adolescent↗
PubMed2001

[Optimization of indirect electrochemical detoxication in the treatment of different endogenous intoxications and multiple organ failure syndrome in resuscitation practice].

The authors have made a statistical analysis of clinical groups of patients in the units of resuscitation and intensive therapy of a general profile and of the archive materials of a laboratory of extracorporeal hemocorrection. The ultraviolet and laser photomodification of autoblood, hemosorption, plasmapheresis, ultra- and hemofiltration were used in the complex treatment of these patients. In the experimental group there were 190 patients on whom 333 operations of extracorporeal hemocorrection were made with using indirect electrochemical detoxication (IECD). In the control group there were 527 patients on whom 1048 analogous operations were made without IECD. The statistical processing of the results obtained has shown that IECD method does not have immediate detoxicating properties in relation to middle mass molecules and fails to substantially influence the processes of lipid peroxidation; sodium hypochlorite did not have a deteriorating effect on the clinical-laboratory status of patients with severe organic disorders. IECD was shown to potentiate the elimination potencies of hemosorption, plasmapheresis, ultra- and hemofiltration which resulted in 2.7 times less lethality. The mean bed-day was 2.8 days shorter, the bed-day in the resuscitation unit--1.2 days shorter.

APACHE↗
PubMed2000

[Extracorporeal hemocorrection in acute pancreatitis].

An experience with using 340 operations of extracorporeal hemocorrection in complex intensive therapy of 160 patients with acute pancreatitis has been generalized. In 111 of these patients (69%) pancreatic necrosis complicated by the syndrome of multiple organ failure was diagnosed. Based on the mechanisms of medical efficiency the authors have developed differential indications for using different extracorporeal technologies depending on the clinico-laboratory profile of the endogenous intoxication, structure and degree of organic and systemic dysfunctions. The adoption of such technologies allowed lethality to be reduced from 37.5 to 27.6%.

Acute Disease↗
PubMed1992

[Antibacterial and detoxification therapy in acute appendicitis].

An analysis of clinical effectiveness of antibacterial therapy, photomodification of autoblood, hemosorption and their combinations was made in 395 patients with acute appendicitis. It was established that no antibacterial and desintoxicating therapy is required in catarrhal appendicitis. The prophylactic application of photomodification of autoblood is thought to be most expedient for phlegmonous appendicitis at the postoperative period, a combination of antibacterial therapy and photomodified autoblood--for gangrenous appendicitis, a combination of antibacterial therapy, photomodification of autoblood and hemosorption--for appendicular diffuse suppurative peritonitis.

Acute Disease↗
PubMed1992

[Fibrinogen metabolism in juvenile uterine bleeding].

The levels of fibrinogen, monomeric fibrin soluble complexes (MFSC), fibrin-fibrinogen degradation products (FDP), and the status of blood coagulation and fibrinolytic systems were studied in girls suffering from juvenile uterine bleedings. Fibrinogen and MFSC levels were found lowered and FDP concentration increased in such bleedings. Fibrinogen concentration correlated with the activities of the coagulating and fibrinolytic systems, and the MFSC level only with the coagulating system activity. Mathematical analysis has revealed a relationship between blood fibrinogen metabolism and the activities of the coagulating and fibrinolytic systems, whose functions in this condition are relatively autonomous.

Adolescent↗
PubMed1992

[Disorders of immunity in chest and abdominal injuries].

Under study were disturbances in the immune competent system in 245 patients with injuries of the chest and abdomen in dynamics of the early posttrauma period. Specific features of the disturbances were analyzed in the complicated and noncomplicated course of the trauma disease. The informative value and prognostic significance of certain indices are discussed as well as approaches to immune correction.

Abdominal Injuries↗
PubMed1991

[Endogenous intoxication in chest and abdominal injuries].

Results of clinico-laboratory examinations of the endogenic intoxication in patients with injuries of the chest and abdomen are presented. Correlative relationships of the endogenic intoxication parameters and their association with the degree and character of injuries were established, the clinical informative value and prognostic significance of certain laboratory tests were determined. A conclusion is made on the necessity of a correction of endogenic intoxication in complex treatment of these patients.

Abdominal Injuries↗
PubMed1991

[A method of studying the absorbent phase of phagocytosis].

A method has been developed for examining phagocytosis, making use of the Soviet latex RFD-48. Optimal conditions of the procedure were specified, and results of measurements in normal subjects and patients and laboratory animals presented.

Absorption↗
PubMed1991

[The effect of autotransfusion of photo-modified blood on the growth of Walker's carcinosarcoma].

The study deals with the influence of autotransfusion of blood treated with ultraviolet light on the growth of experimental Walker's carcinosarcoma in rats. Animals of the study group survived longer than controls. Autotransfusion of the photo-modified blood did not influence tumor growth rate. The anti-anemic action, the inhibitory effect on lipid peroxidation and retardation of immunodepression by photo-modified blood are the possible mechanisms accounting for an increase in resistance to tumor growth in rats.

Animals↗
PubMed1991

[Crohn disease].

Among 2,443 patients who underwent operation for acute appendicitis in a period of 9 years 19 had Crohn's disease. The specific features of the clinical picture and the morphological changes are described. The diagnosis and surgical tactics in Crohn's disease are discussed. It is emphasized that alertness in relation to this disease in emergency surgery is necessary because of the danger of the development of grave complications. Recommendations with regard to the treatment of patients in the postoperative period are given.

Acute Disease↗
PubMed1990

[Metabolism of fibrinogen].

Fibrinogen metabolism was studied with the use of coagulation and enzyme immunoassay techniques for measuring its concentrations and the levels of fibrinogen (fibrin) degradation products and of monomer fibrin soluble complexes in adults and children in health and disease. The detected age-associated and nosologic changes in fibrinogen and its metabolites' concentrations are discussed, as is the practical value of the methods employed.

Abdominal Injuries↗
PubMed1990

[Therapeutic choices in spontaneous pneumothorax].

Questions of conservative and operative treatment are considered on the basis of studying 259 patients with spontaneous pneumothorax. In most of the patients the lung was spreaded by a single or permanent active aspiration of air from the pleural cavity. However, due to great amount of recurrences after the conservative treatment it should be more often followed by operative methods of treatment. Indications to operation are: failure of conservative spread of the lung, repeated collapse, recurrent pneumothoraxes and detection of subpleural bullas during thoracoscopy.

Adolescent↗
PubMed1990

[Pathogenesis of experimental peritonitis].

It was found that joint action of two independent factors is necessary for the development of peritonitis. They are: prolonged infection of the abdominal cavity and an inflammatory process caused by an extraperitoneal source. Investigations of the endogenous intoxication, system of regulation of the aggregate state of blood, immunity, esterase and antitrypsin activity in dynamics of the development of experimental peritonitis and septic shock were performed.

Animals↗
PubMed1990

[Endogenous toxemia in surgery].

An analysis of the mechanisms of the development of endogenous intoxication was used to consider its role in pathogenesis of most serious surgical diseases and traumas and their complications. The role of endogenous intoxication is shown in the development of multiple organ insufficiency. Methods of extracorporal hemocorrection in treatment of endogenous intoxication are substantiated. Potentialities of the present-day methods of extracorporal hemocorrection and prospects of development are discussed.

Bacterial Infections↗
PubMed1990

[Limited proteolysis activation syndrome in surgery].

Under consideration is an original author's conception, formulated previously, of the syndrome of activation of limited proteolysis as an obligatory pathogenetic link of all pathological processes including the alteration at the tissue level as applied to surgical diseases. A universal character of the syndrome in acute and chronic surgical diseases and traumas, its role in their pathogenesis was shown in 1107 patients and 130 experimental animals. Variants of the course of the syndrome in different diseases are considered both in the postoperative and posttraumatic periods. The significance of the syndrome of activation of limited proteolysis for practical surgery is discussed.

Cardiovascular Diseases↗