Biomedical subjects

V V Chumak

Publications and source records attributed to V V Chumak.

8 recordsLinked to original sources

PubMed2005

High precision EPR dosimetry as a reference tool for validation of other techniques.

We present here a particular application area for EPR dosimetry with teeth--use as a source of reference dose values for validation/verification of other retrospective dosimetry techniques and existing dose records. The conditions of application of EPR dosimetry in this role as well as practical design of such studies are shown. Particular attention is given to the requirements to the techniques in terms of precision and throughput, as well as to the issue of availability of samples for analysis and practical solution of this problem. Practical application of this approach is illustrated by several examples of completed validation sub-studies, which were performed in the framework of large-scale post-Chernobyl epidemiological studies.

Benchmarking↗

PubMed2005

Variability of parameters in retrospective EPR dosimetry with teeth for Ukrainian population.

Variability of EPR signal parameters in retrospective dosimetry with teeth has been studied among five different oblasts (regions) of Ukraine. It was found that the native signal in enamel is region-invariant and has peak-to-peak width of 0.85+/-0.01 mT and intensity of 1.0+/-0.20 normalized units. Low-frequency background signals in the spectra of enamel, expressed in terms of dose were estimated to represent 1520 mGy. Variability of radiation sensitivity among different teeth (inter-sample variability measured using 100 mg aliquots) was (+/-)4% while among different parts of one tooth (intra-sample variability measured using 5-10 mg aliquots)--(+/-)7%.

Adult↗

PubMed2003

Relationship between protection and operational quantities in dosimetry of photon external exposure-deficiencies of Hp(10).

It is commonly assumed that, for a variety of conditions, the E/Hp(10) conversion coefficient is below unity, i.e., Hp(10) can be used as a conservative surrogate of effective dose. The validity of this assumption was checked by Monte Carlo simulation of E and Hp(10) as determined by a practical dosemeter. The calculations concerned irradiation by parallel photon beams with directions varying within a 4pi solid angle and energy ranging from 50 keV to 1 MeV. Observed dependences of conversion coefficients on irradiation geometry, photon energy and dosemeter position demonstrate that in strongly anisotropic radiation fields straightforward application of Hp(10) for assessment of effective dose may lead to significant underestimation of the latter. For photon energy of 80 keV this underestimation may be up to 16-fold. For simulation of real life situations, irradiation by photons coming within broad cones (with solid angle pi) was considered. It was found that even for this irradiation geometry, E/Hp(10) may be as high as 4.3. At the same time, for radiation coming from the frontal hemisphere, the values of the conversion coefficient for a typically positioned (i.e., the left chest pocket) personal dosemeter do not exceed unity. The conclusion was reached that prior to application of Hp(10) as a surrogate of effective dose, the information regarding angular distribution of radiation fields must be taken into account.

Body Burden↗

PubMed2000

Some aspects of EPR dosimetry of liquidators.

Doses of few hundred liquidators were reconstructed using EPR dosimetric technique, developed and routinely used in SCRM. Both cumulative and accidental dose values were determined. Obtained results are analyzed and discussed.

Dental Enamel↗

PubMed1997

Emerging technological bases for retrospective dosimetry.

In this article we discuss examples of challenging problems in retrospective dosimetry and describe some promising solutions. The ability to make measurements by accelerator mass spectrometry and luminescence techniques promises to provide improved dosimetry for regions of Belarus, Ukraine and Russian Federation contaminated by radionuclides from the Chernobyl accident. In addition, it may soon be possible to resolve the large neutron discrepancy in the dosimetry system for Hiroshima through novel measurement techniques that can be used to reconstruct the fast-neutron fluence emitted by the bomb some 51 years ago. Important advances in molecular cytogenetics and electron paramagnetic resonance measurements have produced biodosimeters that show potential in retrospective dosimetry. The most promising of these are the frequency of reciprocal translocations measured in chromosomes of blood lymphocytes using fluorescence in situ hybridization and the electron paramagnetic resonance signal in tooth enamel.

Animals↗

PubMed1996

Estimation of 131I thyroid doses for the evacuees from Pripjat.

The thyroid doses of 49,360 inhabitants of Pripjat evacuated after the accident at Chernobyl were reconstructed. During their evacuation most of the evacuees passed through highly contaminated territories. The evaluation of a large-scale public survey showed that only about 50% of the evacuees had left the contaminated areas within 5 days and that 30% of them stayed there for more than 30 days. As a first step, the model of dose estimations was improved, and thyroid doses were assessed for the group of evacuees for whom the 131I activity in the thyroids was measured. The 131I incorporation during the first 5 days after the accident was described by a single-intake model (inhalation); later incorporations were assumed to be proportional to the radioiodine activity in milk. As a second step, the correlation between the calculated doses and individual parameters (place of residence in Pripjat, intake of stable iodine, and age at the time of the accident) was described by an empirical equation. This equation was applied to all evacuees who completed the questionnaires of the public survey. Previous dose assessments were found to overestimate the thyroid doses especially for the younger evacuees. On the basis of these estimations, collective doses and the resulting radiation risks for thyroid cancer were assessed for different age groups.

Adolescent↗

PubMed1996

Dosimetric support of the International Programme on the Health Effects of the Chernobyl Accident (IPHECA) pilot project: main results and problems.

The problem of post-Chernobyl dosimetry is unique in its complexity in the history of radiation medicine and radiation protection. This is because the early experience of mass exposure of people (bombing of Hiroshima and Nagasaki, Windscale and South-Ural accidents, exposure of inhabitants of Nevada in the United States of America, the Semipalatinsk area in the former USSR, the Marshall Islands, and the Goiånia accident in Brazil, and others) differed both in the much simpler structure of the irradiation source and in the number and characteristics of exposed persons. It is obvious that post-Chernobyl dosimetry, both as an independent problem, and as a tool for epidemiological studies, requires significant expertise and economic and technical expenditures. Extensive and deep research has been carried out in Ukraine for the past 10 years. This article reviews the main results of these studies.

Adolescent↗

PubMedDate not supplied

[The experience of FISH technique application for reconstruction of individual radiation doses in Chernobyl liquidators in the framework of Ukrainian-American project "Leukemia"].

The results of proper investigations received under the cytogenetic examination of 225 persons (control groups, Chernobyl liquidators exposed to different radiation doses, oncogematology patients) had been summarized and analyzed. The conclusion concerning possibilities and limitations of FISH technique usage for retrospective biodosimetry of human radiation exposure has been presented.

Adult↗