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Biomedical subjects

V V Dmitriev

Publications and source records attributed to V V Dmitriev.

At least 19 recordsLinked to original sources
PubMed1999

[Levels of biologically active substances in the blood of patients resistant and nonresistant to antihypertensive therapy].

AIM: To clarify the role of differences in the levels of some biologically active substances (BAS) in plasma of patients with resistance to therapy or without it measured before treatment, during treatment and application of plasmapheresis. MATERIALS AND METHODS: Resistance to therapy was assessed clinically and according to 24-h monitoring in 35 patients aged 35-56 years with essential hypertension (n = 19), related to chronic pyelonephritis (n = 13) and glomerulonephritis (n = 3). Plasma BAS were studied by radio- and enzyme immunoassays. RESULTS: Blood pressure monitoring provided more precise determination of the treatment responders than clinical tests. Initially, responders to therapy had higher level of endothelin-1 and low of hydrocortisone. CONCLUSION: Responders to antihypertensive therapy were distinguished by a significant decrease of plasma aldosterone within a year vs aldosterone levels before the treatment. Nonresponders had no significant decrease of plasma aldosterone. No other marked differences in plasma BAS between the responders and nonresponders to antihypertensive treatment were found.

Adult↗
PubMed1996

[The prolonged-action form of Lomir (isradipine) in the treatment of mild and moderate essential hypertension].

24-hour monitoring of arterial pressure has been performed outpatiently in 20 subjects with mild or moderate essential hypertension using portable system Space Labs 90207. The design of the study implied 2 weeks of observation without any treatment followed by a 4-week course of lomir SRO-5 plus a 2-week course of lomir administration in a double dose. Control examination was performed at the end of each period. It was established that a 4-week lomir course results in a lowering of systolic and diastolic pressure by 8.4 + -2.1 and 6.9 + -1.3 mm Hg, respectively. Double-dose lomir was also effective: a fall in both systolic and diastolic pressure by 15.6 + -3.2 and 8.1 + -1.8 mm Hg, respectively, was achieved.

Adult↗
PubMed1995

Cytological aspects of resistance to potassium tellurite conferred on Pseudomonas cells by plasmids.

The ultrastructure of strains Pseudomonas putida BS228 and Pseudomonas aeruginosa ML4262 harboring plasmids pBS10, pBS31, and pBS221, which determine resistance to potassium tellurite, was studied. Bacteria were grown in media containing increasing concentrations of potassium tellurite. Crystalline structures containing tellurium appeared in their periplasmic space. The dynamics of crystal growth was studied. Crystals were released into the medium by pinching off of the outer membrane vesicles containing growing crystals. A possible mechanism of this process was described; cytobiochemical peculiarities were discussed.

Crystallization↗
PubMed1995

[Changes in biogenesis and secretion of periplasmic alkaline phosphatase, coded by the phoA gene included in the Escherichia coli DH1 plasmid].

Augmented synthesis of periplasmic alkaline phosphatase from E. coli DH1 coded by the phoA gene within the composition of plasmid pHI-7 results in alterations in the enzyme biogenesis, such as accumulation of intermediate enzyme forms corresponding to various stages of its posttranslational modification, and alternative localization. The cell cytoplasm was found to contain a large proportion of alkaline phosphatase precursors in the form of insoluble aggregates. The mature enzyme was detected in both the periplasm and the cultural fluid in the form three methazymes with an increased (as compared with the original strain) content of methazymes I and II. The cell envelope of E. coli DHI transformed by plasmid pHI-7 with the phoA gene differed from that of the original strain by an increased acid phospholipid (cardiolipin/phosphatidylglycerol) ratio as well as by increased distribution density of intramembrane particles on the surface of the cytoplasmic membrane facing the cytoplasm. Changes in the biogenesis of the enzyme during its augmented synthesis are due to disturbances in the equilibrium between the synthesis of polypeptide chains, on the one hand, and their translocation and processing, on the other, apparently as a result of restricted secretion sites and lack of inhibition of translation of secreted proteins in bacteria.

Alkaline Phosphatase↗
PubMed1995

[Detection of polyphosphatase activity in isolated Saccharomyces cerevisiae nuclei].

Intact nuclei have been isolated from cells of a diploid strain of Saccharomyces cerevisiae. The isolated nuclei were free from cytoplasmic, mitochondrial and vacuolar marker enzymes. The protein to DNA ratio (w/w) was 11. Pyrophosphatase, tripolyphosphatase and exopolyphosphatase activities have been found in S. cerevisiae nuclei for the first time and were equal to 400, 130 and 55 mU/mg of protein, respectively.

Acid Anhydride Hydrolases↗
PubMed1994

[A new approach to the evaluation of the effectiveness of antihypertensive therapy in patients with mild and moderate arterial hypertension based on the example of isoptin retard].

Isoptin-retard (Knoll, BASF) in a single dose 240 mg/day provides a significant hypotensive effect in patients with mild and moderate essential hypertension noticeable as early as treatment day 2. Sensitivity to the drug does not tend to decrease with time. The treatment should be conducted under ECG monitoring.

Blood Pressure↗
PubMed1993

[Isoptin-Retard 240 mg in the treatment of mild and moderate arterial hypertension].

To elucidate a hypotensive effect of isoptin-retard in a dose 240 mg/day, 17 males with mild and moderate hypertension receiving the drug underwent 24-h monitoring by SpaceLabs 5300 and pressure loading. A significant lowering of both mean systolic and diastolic pressure was found both in daytime and at night. A hypotensive effect persisted for 2 months. No case of serious cardiovascular complications, of noticeable shifts in blood biochemistry was reported.

Blood Pressure↗
PubMed1991

[Carbohydrate and energy metabolism in the dynamics of DIC syndrome in children with pyo-inflammatory diseases].

The changes in carbohydrate and energy metabolism were established to be inconclusive in patients with different stages of the DIC syndrome. Optimization of carbohydrate and energy metabolism performed in a differentiated manner, bearing in mind the depth of hemostatic disturbances is one of the main trends in the treatment of the DIC syndrome in children suffering from pyo-inflammatory diseases.

Adolescent↗
PubMed1989

[Disseminated intravascular coagulation in newborn infants with infection].

The treatment of disseminated intravascular coagulation (DIC) in infants with sepsis should be instituted after multimodality therapy of pyo-inflammatory diseases taking into account the degree of hemostatic disorders. In stage I DIC (hypercoagulation one), it is necessary to reach an adequate level of the inhibitors of the thrombin and plasmin systems. In this case it is quite sufficient to use donor's cryoplasma without heparin administration. In stage II DIC (transitory one) and stage III (hypocoagulation one), it is required that the drugs possessing antithrombin and antiplasmin activity, substitution therapy with blood preparations and components as well as measures to control hemorrhagic diathesis may be used.

Antithrombins↗
PubMed1987

[Indications for using heparin in diffuse suppurative peritonitis in children].

In non-complicated course of diffuse purulent peritonitis in children the anti-thrombin (frozen plasma) drugs are thought by the authors to be sufficient for purposeful correction of disturbed hemostasis in children. The appearance of laboratory signs of IDS and clinical manifestations of functional insufficiency of parenchymal organs are considered to be an indication to use frozen plasma and heparin irrespective of previous operations.

Child↗