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Biomedical subjects

V V Dorokhov

Publications and source records attributed to V V Dorokhov.

12 recordsLinked to original sources
PubMed1991

[Forced insulin coma therapy and its efficacy].

The title method was applied to the treatment of schizophrenic patients suffering from schizoaffective, paranoid and hallucinatory paranoid attacks. Definite correlations were established between the development of insulin coma and the type of the reverse development of psychosis. Five variants of schizophrenia reduction due to the treatment method under consideration were distinguished and described: variant 1--harmonic critical, variant 2--harmonic lytic, variant 3--disharmonious deliric, variant 4--disharmonious affective, and variant 5--incomplete reduction. The established correlations between variants of the development of insulin coma and the type of psychosis reduction enable one to predict whether the use of forced insulin coma therapy will be desirable and effective.

Chronic Disease↗
PubMed1985

[Pharmacokinetics of cefuroxime in pregnant women with acute pyelonephritis].

The pharmacokinetics of cefuroxime was studied in 40 pregnant women with acute pyelonephritis. The women were in the 2nd and 3rd terms of pregnancy. The antibiotic was injected in a dose of 500 mg. The antibiotic levels in the blood and urine were determined with the agar diffusion method. The pharmacokinetic parameters were measured in a one-compartmental model with regard to antibiotic absorption. The measurement was performed with the use of computer. The cefuroxime concentrations in the blood and urine were practically the same at all periods of the study and at different terms of pregnancy. In pregnant women with acute pyelonephritis, the volume of cefuroxime distribution and the time of a two-fold decrease in the blood antibiotic levels increased. The estimation of the optimal scheme of cefuroxime dosing by the Krueger-Timer principles provided treatment of acute pyelonephritis in pregnant women with intramuscular injections of the antibiotic in a dose of 500 mg every 8 hours for 7-8 days.

Acute Disease↗
PubMed1985

[Ampicillin pharmacokinetics in pregnant women with acute pyelonephritis].

The pharmacokinetics of ampicillin was studied in 38 patients with acute pyelonephritis in the second and third trimesters of pregnancy after the first and the last (28th-32nd) intramuscular injections of the antibiotic. The ampicillin levels in the blood and urine were determined with the agar diffusion method. The pharmacokinetic parameters were estimated in a one-compartmental model by computer The ampicillin levels in the blood and urine of the patients did not practically differ at all the investigation periods (0.5-6 hours after the antibiotic administration) in the second and third trimesters of pregnancy. During the treatment, the rate of ampicillin elimination from the host increased and the period of half-elimination from the blood decreased. The antibiotic levels in the urine within 4-6 hours after the last injection were practically lower in the second trimester of pregnancy as compared with the second trimester. The therapy resulted in an increase in the antibiotic renal clearance, which returned to normal in the second trimester of pregnancy and remained under normal in the third trimester of pregnancy. The increase was due to an approximately 2-fold acceleration of the rate of ampicillin secretion by the renal tubules. The total clearance of ampicillin practically increased in the second trimester of pregnancy and remained decreased in the third trimester of pregnancy. The estimation performed in accordance with the Krueger-Timmer principles on the basis of the characteristic features of the pharmacokinetics of ampicillin shown in the study provides recommendation of the following scheme for pyelonephritis treatment in pregnant women: 500 mg of ampicillin injected intramuscularly every 6 hours followed by gradual decreasing of the intervals between the injections to 4 hours as the rate of ampicillin elimination increases.

Acute Disease↗
PubMedDate not supplied

[Adsorption immobilization of alkaline lipase].

A polyamide with the covalently coupled phosphatidyl ethanolamine was used for affinity adsorption of an alkaline lipase from Pseudomonas aeruginosa. The immobilization resulted in increase of the enzyme specific activity. Some properties of native and adsorbed enzyme were compared. The temperature optima, heat and pH stability, KM and Vmax values were determined for both native and immobilized enzymes.

Enzymes, Immobilized↗
PubMedDate not supplied

[Experimental study of the antiedema activity of antihistamine preparations compared to the dynamics of their concentration in the blood serum].

The time-course of the antiexudative effect of the antihistaminic drugs diphenhydramine, phencarol and suprastin was studied in experimental dextran edema of the rat hind limb after intragastric administration of the drugs in a dose of 50 mg/kg. The data obtained were correlated to the time-course of the blood serum drug concentration measured by high pressure liquid chromatography. The relationship between the pharmacological action of the drugs and the mean maintenance dose was depicted by means of computer. It has been shown that the antiexudative activity of diphenhydramine and phencarol is approximately identical, whereas the efficacy of suprastin is several times less.

Animals↗
PubMedDate not supplied

[Automated system of individual dosage programs (ASIDP) for calculating pharmacokinetic parameters and analyzing the relation between concentration and pharmacological effect].

The authors have developed algorithms and programs that permit introduction in the dialogue mode of the data pertinent to the time-course of changes in the concentrations and pharmacological effects, calculation of up to 20 pharmacokinetic parameters, establishment of the relationship between the effect and concentration, and prediction of the expected effects under different drug dosage regimens. The ASPID is based on the FORTRAN-IV language.

Computers↗
PubMedDate not supplied

[Biosynthesis of lipase by the mold fungus Rhizopus species, strain 3-3].

Cultivation of the microscopic fungus Rhizopus sp. str. 3-3--producer was investigated. Properties of lipase were studied. The technical preparation liparisopin G3x was obtained and examined. pH optimum of the preparation was within 6.0--7.0 and temperature optimum was 37 degrees C (olive oil used as substrate).

Hydrogen-Ion Concentration↗