[Hormonal regulation of the activity of digestive enzymes of the small intestine in newborn rats whose mothers had lack of protein in their nutrition during lactation period].
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to V V Egorova.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Activities of the digestive enzymes (lactase, maltase, saccharose, di-, tri- and aminopeptidases, alkaline and acid phosphatase) in the gastrointestinal tract, the kidney and the liver in one-day-old and adult rats as well as in 10-day-old rats after injections of hydrocortisone (H) or thyroxine (T4) were determined. On the basis of the results obtained it is summarized that (1) high levels of the digestive enzyme activities are observed in the nondigestive organs in immature and adult rats; (2) H induces the enzyme activities in the small intestine more than in other organs; T4 does not influence the activities of the most of enzymes studied both in the digestive and in the nondigestive organs; (3) high activities of a number of enzymes in the colon in one-day-old rats implies its involvement in the digestion at early stages of the ontogenesis.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Characteristics of functional organization and autoregulation of natural polysubstrate digestion in various animals are largely defined by regulatory properties of the enzymes ensuring membrane digestion. This has been demonstrated for both the animals which are at different evolutional levels and those specialized for different types of food. The effective organization of the digestive and transport processes in time and space is provided by an interaction of food substances at the stage of membrane digestion.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Studies have been made on the activity of various digestive enzymes and their distribution between the mucosal, submucosal and muscle-serosal layers of the small intestine in Wistar and Sprague-Dawley rats. Three groups of the enzymes were found, their activities being maximal either in the mucosal, or in muscular layers, or being evenly distributed between three intestinal layers.
Studies have been made on the formation of the spectrum of digestive enzymes in the small intestine of weanling rats which were taken from lactating female and given semisynthetic food at the age of 17, 21 and 25 days. It was shown that the rate of general development and maturation of the digestive enzymes depends on the age of animals and the mode of their breeding (isolated or in a group of the same age). These factors significantly affect also the level of the activity and proximo-distal gradient of distribution of the following intestinal enzymes: lactase, sucrase, alkaline phosphatase, alanine aminopeptidase, glycyl-L-leucine dipeptidase, as well as the mass of the mucose and protein content of the small intestine.
Daily perfusion of the pig small intestine with the sodium nitrate solution entailed a 2-3-fold drop in absorption of glucose and 1.5-2.0-fold drop in absorption of glycine. The sodium nitrate solution being substituted with saline, the absorption of both substances recovered by approximately 80%. The toxic effect of sodium nitrate seems to be due to both the local effect upon the small intestine mucosa and the general effect upon the organism.
With ageing the membrane/soluble form ratio of membrane-boundenzymes increases especially in the ileum and that of peptidases changes rather insignificantly in both portions of the rat small intestine. The soluble forms are supposed to take part in assimilation of food substrates penetrating enterocytes in an unsplit form due to an enhanced permeability of the membranes, particularly those of the ileum.
Explore the source record for details and available documents.