[Mechanism of antihypoxic effect of reserpine].
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Biomedical subjects
Publications and source records attributed to V V Faĭfura.
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Experiments on white rats show that reserpine creates conditions for acetylcholine accumulation in the heart. In early periods after reserpine administration (within 8 hours) this process depends on restriction of mediator hydrolysis. In more distant periods (within 24 hours) synthesis activation adds to the mentioned mechanism.
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The antioxidative activity of ionol, 2,2'methylene-bis(6-tert-butyl-4-methylphenol), 2,2-ethylenebis (6-tert-butyl-4-methylphenol), 2,2-propylenebis (6-tert-butyl-4-methylphenol, 2,2-butylenebis (6-tert-butyl-4-methylphenol) was studied in models and in albino rats with experimental hyperthyroidism. The most intensive extinguishing of induced chemiluminescence was found to be produced by 2,2-methylenebis (6-tert-butyl-4-methylphenol) and 2,2-ethylenebis (6-tert-butyl-4-methylphenol). These substances produced the most inhibitory effects on lipid peroxidation in the heart of hyperthyroidism animals.
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