[Central nervous system involvement in the acquired immunodeficiency syndrome].
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Biomedical subjects
Publications and source records attributed to V V Gavura.
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Results are reported of a study of the clinical course and outcomes of viral hepatitis B. The etiology was confirmed in all patients by detection of the superficial antigen of hepatitis B virus in the blood serum. A clinico-physiological and biochemical follow-up revealed that complete clinical recovery is slow, though the condition of most convalescents does not suffer practically. Viral hepatitis B convalescents revealed in the long-term follow-up residual clinico-biochemical changes.
Autoimmune processes in patients with mild, moderate and severe forms of viral hepatitis B have been studied with the use of a new immunosorbent method for the quantitative determination of autoantibodies (auto-Ab), developed by the authors. The immunosorbent has been obtained on the basis of granulated aerosil, an active protein-adsorbent agent used as a solid antigen carrier. The level of auto-Ab in patients with all forms of viral hepatitis B has been found to exceed the content of such antibodies in practically healthy persons. Besides, in patients with severe and prolonged forms of the disease the content of antihepatic auto-Ab has been found to remain high even after clinical convalescence, which is indicative of the continuation of the autoimmune process.
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The results of clinical observations over patients with encephalitides (E) and meningoencephalitides (ME) of measles etiology are presented. In the majority of patients, E and ME development was related to the severe forms of measles. The diseases developed in both the catarrhal period of measles and in the period of pigmentation and were characterized by a severe course. Neurological complications in patients with measles were most frequently presented by the meningoencephalic syndrome and less commonly by ME and E. The pathogenesis of central nervous system impairments associated with measles is discussed.
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