Biomedical subjects
Publications and source records attributed to V V Gorbachev.
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Blood ACTH, cortisol and lipid levels, as well as complamin effects thereon, were studied in 116 elderly and old coronary patients. Changes of lipid metabolism were not identical in coronary patients of different age. They were particularly unfavorable in old age. ACTH and cortisol levels and the ACTH/cortisol ratio change with age, and the highest hypercortisolemia is found in old age. Complamin regulates lipid metabolism and blood ACTH and cortisol in coronary patients of advanced age. The ACTH/cortisol ratio is however unaffected by treatment and remains stable in all age groups.
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Blood levels of triglycerides, total cholesterol, lipoprotein-fractions cholesterol and testosterone were measured in 122 male patients with coronary disease. The patterns of triglycerides, total and lipoprotein-fractions cholesterol and testosterone were found to be age-dependent in male blood, with more pronounced alteration in elderly patients. A relationship was established between testosterone and cholesterol of high- and low-density lipoproteins in middle-aged and old men.
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The atria and ventricles were shown to differ from each other in: temporal course of contractions, relations between the strength of contractions and the interstimuli interval, resting potentiation, transitional processes after intermissions, character of response to adrenaline. For the first time the adrenaline was shown to annihilate differences in restitution processes occurring in atria and ventricles. The differences of responses in atria and ventricles seem to be due to concentration of endogenous catecholamines which modulate the electromechanical coupling of the rhythmically working myocardium.
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The examination was conducted in 142 patients with coronary atherosclerosis, aged 33 to 74 years, and in 40 normal persons, aged 25 to 48 years. The pain form of the disease was observed in 96 patients, the arrhythmic one--in 38, the painless one--in 8 patients. The arterial pressure was within the normal limits in the examined patients. In 67.6% of the patients hypercholesterolemia was diagnosed, in 47.3%--hypertriglyceridemia. Type II hyperlipoproteinemia was found in 67.6% of the cases, types III and IV--in 5.3 and 9.1%, respectively, type V--in 0.5% of the patients; the type of hyperlipoproteinemia could not be identified in 10.6%, and in 6.9% of the cases the blood level of lipoproteins did not differ from the normal. The plasma renin activity examined by the radioimmunoassay in normals comprised 1.26 +/- 0.21 ng/ml/hour; in patients with the pain form of coronary atherosclerosis--6.67 +/- 0.72 ng/ml/hour; in those with arrhythmias--6.89 +/- 1.20 ng/ml/hour; in those with the painless form--2.39 +/- 1.02 ng/ml/hour. The highest renin activity was revealed in types IIa, IIb and III hyperlipoproteinemia, as well as in paroxysmal arrhythmia and cardiac fibrillation.
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