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Biomedical subjects

V V Iaglov

Publications and source records attributed to V V Iaglov.

At least 19 recordsLinked to original sources
PubMed2000

[Thyroid gland development in Japanese quail embryos incubating in microgravity].

The investigation of the progress of thyroid prenatal development in the Japanese quail has been first performed in the MIR microgravity environment. Development of thyroid glands in control and flight embryos was shown to pass same stages (trabecular and follicular). However, the flight embryos demonstrated retarded a development of the gland as compared to the control one. Slowing-down of thyroid organogenesis in the flight embryos is evidently related to retardation in formation of their blood system and a consequent decrease in blood inflow to the thyroid microcirculatory bed.

Animals↗
PubMed1992

[Experimental research on the efficacy of terrilytin in silicosis].

Experimental silicosis was induced by quartz-containing dust administered intratracheally to Wistar male rats. Proteoclastic enzymes terrilytine was found to arrest pulmonary fibrosis, which was proved by inhibited development of silicotic granulomas and their lowered fibrosis. Terrilytine was most effective when inhaled in a dose of 0.08 PU per rat. Injected intraperitoneally, terrilytine in the dose elevated from 0.1-0.2 to 0.3 PU inhibited fibrosis developing in the presence of marked serous desquamative alveolitis. Incorporation of the enzyme in the cholesterol-lecithin liposomes prevents this side effect in the lungs. Liposomes injected intraperitoneally do not influence the development of pulmonary fibrosis in silicosis.

Adjuvants, Immunologic↗
PubMed1991

[Significance of morphofunctional assessment of tissue basophil reactions in prognostication of harmful effects of chemical substances].

The article contains a comparative analysis of experimental data on the assessment of the general toxicological, gonadotrophic effects and morphofunctional reactions of tissue basophils under the influence of 4-bromine-o-xylene, carbon disulfide and pyracryl. Established was the gonadotrophic action of pyracryl against the growing activity of tissue basophils manifested through increased infiltration and high-level degranulation in female rats' reproductive organs. Demonstrated was that, under the influence of low-intensity chemical factors, tissue basophils morphofunctional reactions were those of organ-related nature. The quantitative assessment of tissue basophils was proposed as an informative model for studies of selective (gonadotrophic) actions of low-intensity chemical substances.

Animals↗
PubMed1991

[The role of fibronectin in the development of fibrosis].

The structure, location, and function of fibronectin are reviewed on the basis of the data available in the literature. The contribution of fibronectin to the pathogenesis of granulomatous diseases, including pneumoconioses is shown in the paper. Formation of pulmonary fibrosis++ in pneumoconioses and its involvement of fibronectin are outlined in detail. The ways of further studies of this glycoprotein in occupational pulmonary diseases are also discussed.

Collagen↗
PubMed1990

[Tissue basophils in vascular plexuses of the lateral ventricles of the brain in humans and various mammals].

By means of histological and histochemical methods cell composition of vascular plexuses in the lateral ventricles of the rats, dogs and man has been investigated. Besides ependymocytes, endotheliocytes, pericytes, myocytes in the microcirculatory bed, described in literature, tissue basophils (TB) have been revealed and what is more--only in dog and man. The most variable forms and localizations of TB are observed in vascular plexuses of the lateral ventricles of the human brain. The following varieties of TB can be defined: small with ortochromic granularity and large ones with abundant metachromic granularity. Sometimes degranulating TB occur. According to their localization they are divided into stromal (+interstitial++), perivascular subepithelial and intraepithelial. The variable TB localization in the vascular plexuses of the brain can probably demonstrate their participation in performing functions of the hematoencephalic barrier.

Adult↗
PubMed1990

[Morphofunctional indices of the effects of pyracryl on the organs of female genital system in rats].

Morphofunctional indices of pyracryl (phosphate poly-2-pyridylethylmethacrilate) effecting reproduction system of Wistar rats have been studied. It has been shown that monthly administration of pyracryl in doses 1 mg/kg and 5 mg/kg lead to infiltration of mast cells and their pronounced degranulation and impairment of blood and lymph microcirculation. As far as gonadotropic effect is concerned, its parametres depend on the administration of pyracryl. Pyracryl in doses of 1 mg/kg stimulates folliculogenesis in ovaries, a dose of 5 mg/kg may cause expressed atresia of growing follicules and changes of oestrous cycle. It is suggested that biologically active substances of mast cells in female reproduction system play an important role in realization of gonadotropic effects of pyracryl.

Animals↗
PubMed1989

[The reaction of the endocrine cells of the gastrointestinal tract in response to exposure to 3,6-dichloropicolinic acid].

Silver-impregnated argentaffin cells both Ec, D1, G, P, S and K enteroendocrine cell types of rat gastrointestinal mucosa were investigated under light and electron microscopy after single oral administration of 3,6-dichloropicolinic acid. As a result, in pyloric-duodenal region Ec cells after a period of 1 hour had intensively secreted hormones. Ultrastructurally their cytoplasm and secretory granules were covered by expressed vacuolization. These data hypothetically elucidate the role of the endocrine regulations in developing barrier function of the gastrointestinal epithelium.

Animals↗
PubMed1987

[Action of dextran-modified hyaluronidase in experimental silicosis].

Dextran-modified hyaluronidase was inhaled or intraperitoneally injected for 4 months to mice with silicosis. Stabilized hyaluronidase was shown to have a marked inhibitory effect on the development of lung fibrosis. Drug inhalation proved to be the most effective. An antifibrotic effect of dextran itself has been observed.

Administration, Inhalation↗
PubMed1987

[Morphofunctional changes in the endocrine system of the small intestine after its proximal resection].

The influence of 50% proximal resection of the small intestine on the intestinal endocrine system was investigated on white male rats. The quantitative changes of argyrophil and argentaffin cells correlated with their secretory activity changes. The opposite character of secretory function synchronization was revealed on the 7th and 30th days along the length of the small intestine (proximo-distal sinusoid phenomenon). The secretory function normalization of the endocrine system is carried out in the distal and proximal direction along the length of the small intestine.

Animals↗