[Complications in the successive use of beta-adrenoblockaders and izoptin].
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Biomedical subjects
Publications and source records attributed to V V Iankin.
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On the basis of monitoring the systolic, diastolic and mean pulmonary artery pressur at rest, during ergometric exercises and under identical conditions following premedicatio with cardiac glycosides (48 measurements in 12 patients with ischaemic heart disease) the authors concluded on the importance of studying this parameter for the diagnosis of initial stage cardiac insufficiency, and on its high informativeness for deciding the indications for initiating therapy with cardiac glycosides.
In 16 rabbit experiments with macrofocal postinfarction cardiosclerosis and 8 control intact animals delayed electron microscopy of myocardium portions from the left ventricle and atria was undertaken, and in 76 clinical observations of patients who had survived a myocardial infarction 1 to 10 years before the examination the indices of the haemodynamic and electrical activity of the atria were compared with those of the contractile function of the left ventricular myocardium under bicycle exercise tests of a growing intensity (with the data of the left ventricular ultrastructure--in the experimental cases). The changes in the left atrium were found to be of an adaptational nature, the right atrium entering the pathogenetic chain when the compensatory capacities of the left atrium got exhausted in the course of the disease, this being a prognostically alerting sign.
The beneficial effect of stimulators of beta-adrenergic structures (Myophedrin on the haemodynamics and the inotropic function of the myocardium was demonstrated experimentally (in 12 rabbits) and clinically (in 53 patients with ischaemic heart disease). A positive effect of the treatment was noted in 45.5% of those patients in whom ischaemic heart disease manifested itself in angina decubitus and angina of effort.