PubMed Health⌕ Search

Biomedical subjects

V V Ivanova

Publications and source records attributed to V V Ivanova.

42 records · Page 3Linked to original sources
PubMedDate not supplied

[Secondary immunologic deficiency states in acute viral infections in children].

Having determined in the time course of the disease the percentage and absolute numbers of T- (according to Bach) and B-(according to Mendes) lymphocytes the authors concluded that there was a secondary immunosuppression in the active stage of the process in three infections: acute viral hepatitis, acute respiratory viral infections and epidemic mumps. In patients with these diseases the percentage of T-lymphocytes decreased. The absolute number of T-cells decreased considerably in patients with moderately severe forms of viral hepatitis, with acute respiratory viral infections as well as with epidemic mumps in the presence of neurotoxicity or the involvement of the central nervous system. The amount of B-lymphocytes increased in patients with respiratory viral infections and epidemic mumps but did not differ from physiological norm in viral hepatitis. The immune response of the patients was restored with the decline of the activity of the pathological process.

Acute Disease↗
PubMedDate not supplied

[Respiratory chlamydial infection in children with a complicated course of acute respiratory viral infections].

The role and influence of Chlamydia trachomatis on the development and course of acute respiratory virus infections (ARVI) in 130 children admitted to the hospital of the Research Institute of Children's Infections (St. Petersburg) was studied. The occurrence of respiratory Chlamydia infections in ARVI patients with an unfavorable premorbid background was 35-36%. The disease took its course simultaneously with the mixed infection of the respiratory tract with viruses, pneumococci and their associations with staphylococci and Haemophilus influenzae. Chlamydia infection in children had no influence on the character of the clinical manifestation of ARVI with the exception of the obstruction syndrome which was constantly observed in children with ARVI (p < 0.001).

Acute Disease↗
PubMedDate not supplied

[Streptococcus pneumoniae adhesion].

The adhesive capacity of 425 S.pneumoniae strains (S- and R-forms) isolated from children with various clinical forms of pneumococcal infection was studied with the use of the epithelium of oral cavity as a model. The strains isolated from patients with meningitis and otitis appeared to be less adhesive than the strains isolated from mucous membrane of respiratory tracts. In all clinical forms of infections the adhesive capacity of S.pneumoniae S-forms was significantly lower than that of R-forms. The hyaluronidase activity and the adhesive capacity of S.pneumoniae strains were found to be inversely related.

Adult↗
PubMedDate not supplied

[The pathogenicity factors of Streptococcus pneumoniae strains causing meningitis].

Pneumococcal meningitis was registered in St. Petersburg in 1985-1991, morbidity rate being 1.7-2.3 cases per 100,000 children, including 7.4-19.8 cases among children under 1 year. Two thirds of the pneumococcal strains isolated in cases of meningitis belonged to serovars 19, 1, 6, 15 and 2. The comparative study of pneumococcal strains revealed that the presence of capsules, pneumolysin, high hyaluronidase activity or belonging to serovars 1 and 2 (irrespective of their hyaluronidase titers) were the most important factors contributing to the development of generalized infection. The role of such a factor as virulence for mice is not yet clear.

Acute Disease↗
PubMedDate not supplied

[Variants of the immune response in the dynamics of the localized form of stomatopharyngeal diphtheria in children].

4 variants of immune response (IR) have been identified according to the dynamics of the development of nonspecific immunosuppression as determined in the reaction of lymphocyte blast transformation to phytohemagglutinin. These variants, characterized by a rise in the production of tumor necrosis factor alpha, interleukin 1 beta, immunoglobulins of 4 classes, are linked with the increased risk of the development of clinically pronounced forms (CPF) of diphtheria. The antigen-specific profile of each of these variants (types) of IR has been studied. Proofs of the fact that each type of IR has definite critical mechanisms of immune protection, contributing to the prevention of CPF of diphtheria, are presented. Treatment with antitoxic antidiphtheria serum produces different effect in 4 types of IR as it acts on different mechanisms of IR.

Adolescent↗