Biomedical subjects
Publications and source records attributed to V V Karpenko.
Blood microcirculation and immunity were studied in 52 patients with rheumatic valve disease associated with pulmonary hypertension. The most pronounced changes were observed in patients with "active" pulmonary hypertension. Microcirculatory and immune disorders are likely to be pathogenetical factors aggravating prognosis of pulmonary hypertension.
Deterioration of the condition in patients with arterial hypertension was found during the critical days of individual biorhythms and correlated with changes in the vascular and intravascular sector of the microcirculation. The peculiarities of individual biorhythms and state of microcirculation in patients with arterial hypertension allow to carry out timely and adequate drug correction of microcirculation disorders and central hemodynamics.
A study is presented of the effect of laser and microwave resonance therapy on the hemodynamics and hemorheology in 56 patients with hypertensive disease. The hypotensive effect of intravascular laser therapy is related to the positive changes, reduction of blood viscosity and general peripheral vascular resistance. The effect of low molecular electromagnetic radiation on acupuncture points favoured clear reduction of peripheral vessel resistance. Combination of laser and microwave resonance therapy produces a positive effect due to potentiation of these methods and, thus, influencing the systems of hemodynamics, hemostasis and hemorheology.
Basing on the response obtained in 46 patients with stage II essential hypertension, the conclusion is made on a positive action of hemosorption plus plasmapheresis on blood rheology, hemodynamics, clinical course of hypertension. The response persisted for up to 6 months.
It was established that use of plasmapheresis in association with hemosorption in 36 patients suffering of hypertensive disease improved the clinical course of the disease, reduced the resistance to drug treatment, increased the treatment efficacy, decreased the risk of complications. Simultaneously there was an improvement of the hemodynamics and hemorheological properties of the blood.
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The state of the greater and lesser hemodynamics in patients with rheumatic mitral heart disease complicated by pulmonary hypertension was analyzed after treatment with peripheral vasodilators and hemosorption. It is suggested that inclusion of hemosorption in the treatment complex favoured reduction of the degree of pulmonary hypertension, improvement of the central hemodynamics which may be directly related to improvement of the rheological properties of the blood.
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A total of 43 patients with primary pulmonary hypertension were examined. The diagnosis was confirmed by invasive techniques and echocardiography. In addition to routine clinical studies, microcirculatory, central and pulmonary hemodynamic ones were used to examine the patients' status and to measure pulmonary pressure. Three groups of the patients were identified: (1) those who received UV-irradiated blood autotransfusion (n = 14); (2) those who underwent hemocarboperfusion with plasmapheresis (n = 15); (3) those who had their own drug therapy (n = 14). The immediate and long-term outcomes of the therapy were analysed. Indications were defined for the usage of extracorporeal techniques in the multimodality treatment of patients with primary pulmonary hypertension.
Bulboangioscopy, aggregate state of the blood, ultrastructural examination of the microcirculatory bed of the skin, ultrasonic examination of the heart revealed that patients with primary pulmonary hypertension and Eisenmenger's syndrome did not show essential differences in the hemodynamics and blood microcirculation. In the treatment of these patients the stage of chronic circulatory insufficiency, vascular and intravascular disorders of the microcirculation should be considered.
The results of psoriasis sorption therapy (hemosorption (HS), plasmosorption (PS), hemosorption with exchanged plasma transfusion) are presented in this work. Indices of immunity and clinical efficiency of sorption therapy in 89 examined patients are studied. It was determined that sorption therapy possessed therapeutic efficiency with clinical forms of dermatosis, it promotes the normalization of immunological status indices, blood aggregation condition and microcirculation.
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Explore the source record for details and available documents.
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Explore the source record for details and available documents.
Application of a mathematical model of microhemocirculation enabled one to assess quantitatively the magnitude of transcapillary albumin metabolism and total hydraulic resistance of metabolic vessels, as well as the effect of geometric, biophysical and hemodynamic parameters on transport characteristics of the capillaries. Dramatic changes in transcapillary metabolism and in blood rheologic properties are classified with factors that determine the occurrence of postoperative complications in patients with mitral valve failure.