[The successful treatment of chronic active hepatitis due to hepatitis C viral infection with alpha-interferon and a cytokine complex (a clinical case)].
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Biomedical subjects
Publications and source records attributed to V V Karpov.
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Field trials were conducted to evaluate effectiveness of mycoses prophylaxis gained by use of antimicrobial insoles and foot-binding with fungicide agents. The trials involved 100 novice soldiers. Bacteriology and bacterioscopy studies diagnosed 47 soldiers as having subclinical mycosis of feet. Using antimicrobial insoles and foot-binding caused considerably lower occurrence of pathogenic fungi in the skin samples; using antimicrobial insoles with regular foot-binding resulted in no changes of the skin microflora. The authors recommend wide application of antimicrobial stuff with fungicide agents for prophylaxis of feet mycosis.
Stationary dermatologic examination covered 32 sufferers from epidermophytosis of soles, who used 3 types of antimicrobial insoles chosen through laboratory investigations. Clinical trials proved that antimicrobial insoles, if applied during 2 weeks, result in considerably decreased occurrence of causal fungus in the patients' surface skin scarring. The results proved fungicidal and bactericidal activity of insoles including furagin, nitrofurilacroleine, polyhexamethylene guanidine, so such insoles could be recommended as prophylactic measure for mycoses of soles.
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A formula of temperature homeostasis of the body during inoculated tumor development was described. The basic data were temperature parameters of tumor S-45 inoculated to 180 rats subcutaneously and intramuscularly. Thermography was used as a method of investigation. An analysis of the results obtained led to a conclusion of a principal difference in the nature of heat processes in the body with tumors at different depths. In addition to it, the heat status of a tumor reflected the state of the vascular system making it possible to assess a necessary degree and nature of therapeutic exposure. Taking into account two periods of a heat status of the body one could choose the most effective therapeutic method during tumor development. The above material formed the basis for producing a heat model of tumor in order to improve methods of cancer diagnosis and therapy.
The growth dynamics of the experimental tumour was analyzed in 180 mongrel rats with sarcoma-45 inoculated intramuscularly and subcutaneously. One of the approaches to the calculation of doubling time is estimated. It is suggested that the changes of the C-45 tumour size may be described according to the function V = A exp(T/B)--C.
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