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Biomedical subjects

V V Korkhov

Publications and source records attributed to V V Korkhov.

At least 19 recordsLinked to original sources
PubMed1992

[Effect of a new prostaglandin aroxaprostol on the contractile activity of the uterus and its abortive action in experimental studies].

Experiments with pregnant and nonpregnant rats have shown that aroxaprostol, a group F2 alpha prostaglandin, injected intravenously and intramuscularly in a dose of 50 micrograms/kg, stimulates the uterine bioelectric activity, increasing both the amplitude and frequency of biopotentials, this evidencing intensification of its contractility. Aroxaprostol has shown an abortive effect, that was related to the luteolytic effect of the drug, manifesting by reduction of progesterone level in the ovaries.

Abortifacient Agents↗
PubMed1989

[The combined and separate use of prostaglandin and adrenergic agents for the purpose of the experimental correction of uterine contractile activity].

Experiments on pregnant rats revealed that a combination of low doses of partusisten and clophelin (1.25 mg/kg and 0.15 ml of 0.001% solution, respectively) potentiated a tocolytic effect. A combination of prostenon and oxytocin given in half doses (0.15 mg/kg and 0.25 IU in 0.1 ml, respectively) summarized their stimulant effect on the myometrium. Premedication with partusisten (2.5 micrograms/kg) failed to change the stimulant effect produced by a combination of prostenon and oxytocin given in half doses.

Animals↗
PubMed1988

[Relation of the progestagenic activity and conformation of the 17beta-acetyl side chain in the D'6-pentarane series].

The synthesis of 2' beta-methyl-16 alpha,17 alpha-cyclohexanoprogesterone and its MM2 conformational analysis have been performed. The acetyl side chain was shown to have an unusual conformation with the torsion angle C13-C17-C20-O20 being -32.1 degrees. This conformation is by 5.4 kJ.mol-1 more stable than the usual one with the torsion angle 130.3 degrees. 2' beta-Methyl-16 alpha,17 alpha-cyclohexanoprogesterone proved to be inactive as a progestogen (pregnancy maintenance and McPhail tests). The lack of the activity may be due to the additional methyl group in D'-ring causing a change of the conformation of the 17 beta-acetyl side chain, thus hindering the formation of the conformation necessary for binding to the progesterone receptor.

Animals↗
PubMed1986

[Progestagenic activity and the mechanism of the contraceptive action of mecygeprone].

Progestagenic activity of a modified analog of progesteron-6 alpha-methyl-cyclogexan-[1', 2', 16 alpha, 17 alpha]-pregn-4-en-3,20-dion including into mecygepron composition has been studied; its activity is proved to be 5 times as great as that of progesteron at any way of administration. Mecygepron affects processes of ovogenesis and early embryogenetic development in rats. A decreased number of washed out embryos is observed, while the number of lutein bodies specific for intact rats remains the same, decelerated rate of cleavage and increased number of unfertilized ova. In the mechanism of the changes observed an essential role plays a decreased secretion of lutropin resulting in a prolonged estrol cycle and, evidently, in intrafollicular overmaturation of the ova, which loose their ability to be fertilized. Besides, the disturbed hormonal balance under mecygepron influence can affect the character of the oviduct and uterine contents and, thus, prevent the normal development of the fertilized gametes.

Administration, Oral↗