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Biomedical subjects

V V Mikhaĭlichenko

Publications and source records attributed to V V Mikhaĭlichenko.

At least 19 recordsLinked to original sources
PubMed1998

[A method of phalloplasty using a non-free skin-fat flap from the thigh].

The authors propose a method of phalloplasty with a full-thickness flap on the vasculo-nervous pedicle taken from the femur. The method of raising such a flap and the technique of its displacement to the area of the pubic articulation if described. This method of phalloplasty was used in 10 patients aged 19-36 years. In all of them full taking of the transplant was noted. Good cosmetic and functional results were obtained.

Adult↗
PubMed1994

[A luminescent cytological method of the determination of sex gonad hormonal activity in males].

A method for assessing gonadal hormonal activity in men is suggested. It consists in fluorescent and cytologic examinations of navicular fossa epithelium making use of a fluorescent marker (acridine orange) and is based on specific sensitivity of navicular fossa epithelium to male sex hormones, because navicular fossa is formed in the course of embryogenesis from the urogenital sinus under the effect of androgen induction. Navicular fossa epithelium reacts to changed androgen/estrogen ratio by restructuring which is characterized by cellular apparatus regression or depression. Parallel with the cytologic reaction, blood androgen levels were measured in patients and normal subjects. The authors have developed a classification singling out four basic and four intermediate epithelial reactions. The suggested method was used in examinations of 327 patients with various andrologic abnormalities and of 96 healthy men. Examinations have demonstrated a high diagnostic value of this method in assessment of the hormonal balance (androgens and estrogens) in men and the possibility of using it as a screening test in andrologic abnormalities.

Acridine Orange↗
PubMed1989

[Electrophoretic study of protein secretion by the prostate gland in chronic prostatitis and pathospermia].

Disk electrophoresis of prostatic secretion proteins in polyacrylamide gel has been employed in examinations of 294 normal subjects and sterile patients with oligo- and asthenospermia in the presence of and without chronic prostatitis. The electrophoregrams have been examined visually; the electrophoretic mobility (EPM) of individual fractions relative to the length of the indicator run has been determined. Analysis of the electrophoretic picture, the microscopy findings of examinations of prostatic secretion and the ejaculate, and of the blood levels of sex and gonadotrophic hormones in the patients has revealed that the progress of the inflammatory process in the prostate is associated with a drastic decrease of the concentrations of prostatic secretion proteins with a high molecular mass and an increased level of low-molecular proteins. Abnormal spermatogenesis without prostatic inflammation is linked with a different pattern of prostatic protein levels. A specific electrophoretic picture is characteristic of congestive prostatitis, this helping to differentiate this condition from prostatic inflammations. High informative value and good reproducibility of disk electrophoresis of the prostatic secretion proteins recommend this method for wide use in practical andrology.

Adult↗
PubMedDate not supplied

[Immune male infertility: correction with efferent therapy].

Effects of plasmapheresis and hemosorption on efficacy of the treatment of autoimmune male infertility (AMI) were studied in 289 AMI males with oligoasthenozoospermia aged 19 to 37 years. The males were divided into three groups by the levels of antisperm antibodies (ASAB) in the blood and ejaculate. The study was made of cellular and humoral immunity, intensity of protein and lipid free radical oxidation and antioxidant defense. Patients of group 1 with high ASAB in the blood but low in ejaculate received a course of plasmapheresis. Patients of group 2 with high ASAB both in the blood and ejaculate were subjected to hemosorption and plasmapheresis in one contour. Group 3 patients with high ASAB in ejaculate but low in the blood received efferent therapy only after medication and photomodification of the blood. The treatment reduced elevated levels of ASAB in the blood and ejaculate, normalized free radical oxidation, cellular and humoral immunity, antioxidant defense. This resulted in improvement of spermogram parameters, efficacy of assisted reproductive technologies, higher probability of natural pregnancy in the patients' wives.

Adult↗
PubMedDate not supplied

[Sexual function after the surgical treatment of acute epididymitis].

Operative management of acute epididymitis performed in 150 patients aged 18-67 produced better therapeutic results compared to 150 patients treated conservatively (9.1 patient day versus 13.3 days). Follow-up for 2-4 years showed marked intergroup differences as regards anatomic changes in the epididymis revealed by palpation and ultrasound scanning. Echographic pattern was altered in 25 operated on and 92 patients treated conservatively. Copulative function was diminished in few cases in those operated on and much more frequently after conservative treatment, libido and erection in particular. Reproductive function was impaired more profoundly after conservative treatment as well. These patients demonstrated lower levels of testosterone and estradiol but higher content of LH and FSH. The latter hormones did not vary with age among the groups. Better effect of scrotal drainage in acute nonspecific epididymitides is attributed to the influence of inflammation-affected epididymis on the contralateral testicle more intensive under conditions of closed (nondrained) inflammation.

Acute Disease↗
PubMedDate not supplied

[The treatment of Peyronie's disease].

The paper considers results of conservative and operative treatment of Peyronie's disease in 128 patients of 23 to 60 years of age. The patients were assigned to 3 groups according to severity of clinical symptoms. Efficacy of conservative treatment was best in group 1, worse in group 2 and poor in group 3 patients. Satisfactory short-term sexual performance was reported by 71 patients (55.4%). However, long-term efficacy was seen only in 32 of 62 patients. A lack of it required various operations in 62 patients. Follow-up examination (2 to 15 years) was done in 107 patients. A good or fair outcome allowing sexual activity was seen in 59 men (55.1%). Functional outcome was found to be poor in 48 men (44.9%). The outcome was best in patients with intracavernous shafts. The analysis of long-term outcome indicates a need for newer, more efficient treatment modalities.

Adult↗
PubMedDate not supplied

[Methods for correcting retardation of sexual development in the irregular puberty syndrome in boys].

A total of 46 boys aged 11 to 13 with the abnormal puberty syndrome were examined. The authors assessed various methods of correction of delayed puberty by the time course of anthropometric and genitometric indices and blood testosterone, LH and FSH levels 1 year after the initiation of treatment, at the age of 14 to 16 and 17 to 19. The ejaculate composition of 12 adolescents over 17 was examined. In 3/4 of the adolescents the indices of physical development and pubescence, blood testosterone and gonadotropic hormone levels achieved physiological values by the age of 14-16, but in 1/4 of the patients delayed puberty with lowered FSH and testosterone levels and raised LH in the blood was noted. The normalization of puberty was noted at the age of 17 to 19 with normal spermatogenesis. The necessity and methods of therapeutic correction of delayed puberty in boys and adolescents with the abnormal puberty syndrome were discussed.

Adolescent↗