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Biomedical subjects

V V Peresedov

Publications and source records attributed to V V Peresedov.

36 records · Page 2Linked to original sources

[Combined surgical treatment of associated lesions of the major arteries of the head].

Concurrent affection of the main arteries of the head is the cause of vascular cerebral insufficiency in more than half of the patients, which makes necessary combined operations on the extra- and intracranial arteries. The sequence of the operations is determined by the degree of the threat of occlusion of the stenosed artery or by the side on which the cerebrovascular insufficiency is manifested. Information on the regional cerebral blood flow and the results of ultrasonic dopplerography and computed tomography are additional criteria for determining the sequence and the terms of the operations. Experience in 61 combined operations allows the authors to consider them to be an effective method for the surgical management of concurrent affections of the main arteries of the head.

Adult↗

[Stereotaxic removal of intracranial hematomas].

The high lethality and frequent postoperative complications in surgical treatment of intracerebral hemorrhages stimulate the search for new methods of their management. The introduction of computer tomography into clinical practice provided the grounds for elaborating a stereotaxic method for sparing removal of intracerebral hematomas. Experience in the clinical use of the method (54 operations on 51 patients) allows its results to be considered encouraging. Lethal outcomes amounted to 24%, while the possibilities of functional restoration were higher than in the other types of surgical and nonoperative treatment.

Adult↗

[Surgical treatment of deformities of the extracranial division of the vertebral artery].

Bends and twisting are encountered most frequently in the first segment of the vertebral artery (VA), annular and spiral torsions are rare findings. In insufficiency of circulation in the vertebrobasilar channel, operation is indicated in VA bends at an angle of no less than 90 degrees and twisting and torsion with the arc radius of 5 mm and less. Surgery includes removal of the fibrous strands, arteriolysis, desympathization, scalenotomy, and immobilization of the artery in a cuff of muscular or fat tissue. As the result of surgery the deformities may be corrected completely or changed to elongations with the arc radius measuring 10 mm and more. Operative interventions were performed for deformity of the first VA segment on 25 patients with good immediate and late results.

Adult↗

[Morphologic changes in an artery feeding an arteriovenous aneurysm over a long period following its embolization].

Different materials are used in operations for embolization of arteriovenous aneurysms on which radical operation cannot be performed. A case is described with successful embolization by means of silicon-tantulum balls of vessels supplying a giant arteriovenous aneurysm. The patient died 6 years after operation from recurrent massive hemorrhage with escape of blood into the ventricles. Morphological examination of the artery revealed neither necrotic or inflammatory changes in its walls at the site of the embolism.

Adult↗

[Stereotaxic clipping of cerebral arteriovenous aneurysms].

The method of stereotaxic clipping was used in the surgical treatment of 14 patients on whom 16 operations were conducted for clipping of the afferent vessels of arteriovenous aneurysms. A stereotaxic atlas was used for the first time to determine the localization of the aneurysms and the structures they occupied. In 12 patients the aneurysms were found to be unsuitable for radical operation. Besides angiography, examination of the volumetric cerebral blood flow was conducted by the modified Kety and Schmidt method to appraise the eficacy of the operation. The examination of 5 patients showed marked (approximately by half) decrease in the bloodflow after operation in 3 patients and its normalization in 2 patients.

Adolescent↗

[Stereotaxic biopsy of brain tumor using computer tomography].

The work discusses the results of the clinical application of a modified method of stereotaxic biopsy of deeply located brain gliomas according to the results of computer tomography. In some patients with gliomas of subcortical localization stereotaxic biopsy was combined with cryodestruction of the tumour. The method makes it possible to extend the possibilities for precise diagnosis of deeply located three-dimensional processes in the brain, to clearly define the limits of their operability and to cause an effect on them by means of the cryosurgical method.

Adolescent↗

[The surgical treatment of patients with tandem atherosclerotic stenosis of the internal carotid artery].

The paper specifies indications and contraindications for brain microrevascularization and carotid endarterectomy in patients with atherosclerotic tandem stenosis of the internal carotid (IC) and provides strong evidence for the succession of their implementation. It also notes the role of tandem lesion as a factor predisposing to IC occlusion after carotid endarterectomy. It is shown that brain microrevascularization serves as the method of choice, when other correcting measures for cerebral blood flow disorders fail, and aims largely at preventing local cerebral ischemia.

Adult↗

[Combination of aneurysm and primary echinococcosis of the brain].

Aneurysm of the supraclinoid portion of the left internal carotid artery with rupture of its wall and a primary calcified echinococcus of the left frontal wall were discovered in a patient who had a history of general epileptic seizures. Death occurred from massive subarachnoid hemorrhage due to rupture of the aneurysm.

Brain↗

[Lifetime diagnosis of prion transmissive encephalopathies].

An original method for life-time diagnosis of Greutzfeldt-Jakob's disease, a neurodegenerative disease belonging to transmissive spongiform encephalopathies, is proposed. It consists in inoculation of the examined biological materials (blood serum and clot) into a continuous culture of the rat Gasser's node neurinoma, followed by passages and study of the inoculated culture by morphological methods and electron microscopy.

Animals↗

[A treatment procedure for nontraumatic cerebellar hemorrhages].

The results of surgical treatment of 12 patients with non-traumatic intracerebellar hemorrhages are analyzed in this paper. The following parameters were assessed: clinical signs and symptoms, the level of consciousness, location and size of the lesion, the brain stem deformation, the rupture of hematoma into the adjacent ventricle, and hydrocephalus. In all patients with fulminant course as well as in the majority of patients with acute or subacute course when the brain stem compression progresses and seems to be unresponsive to medical treatment, surgery is strongly indicated. Among the surgical procedures, placement of the external ventricular drainage and extensive midline suboccipital craniectomy are curative. These procedures proved to be effective in reducing the brain stem compression. Patients with chronic intracerebral hematomas are followed conservatively.

Adolescent↗

[A comparative assessment of the results of surgical and conservative treatments in parkinsonism].

Late outcomes of surgical and medical treatment of parkinsonism were studied in 582 (including 321 medical and 261 surgical) patients. The follow-up ranged from 6 to 30 years. Three hundred and fifty eight surgeries were performed. In immediate postoperative period, the following results were observed: significant (64%), moderate (20.3%) improvements, no changes (8%), deterioration (3.1%). Late outcomes were as follows: significant (34.9%), moderate (20.3%) improvements, no changes (28.7%), deterioration (16.1%). In surgical patients the complication rate was 14.8%, mortality 0.8%. Analysis of outcomes of surgical and medical treatment showed a statistically significant predominance of good outcomes in surgical patients (34%) as compared with medical ones (14%).

Chronic Disease↗

[The surgical results in patients with different forms of torsion dystonia].

The paper describes stereotactic operations made in 278 patients with different forms of torsion dystonia during 20 years. Late outcomes were studied and assessed in 130 patients. The duration of follow-ups was 3 to 23 years. The patients' mean age at surgery was 30.5 years. The indications for surgical treatment were ineffective medical treatment and progressive disease. Positive early and late postoperative outcomes were achieved in 93 and 70% of patients, respectively. Complications developed in 3.2 and 12.3% of patients after the first and second operations, respectively. The positive outcome depends on the form, etiology, the destructible structure or a complex of structures. Surgical treatment of patients with torsion dystonia by stereotactic operations on basal ganglia is an effective treatment that provides a steady-state positive result in 70% of patients in the late period.

Adolescent↗