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Biomedical subjects

V V Poltorak

Publications and source records attributed to V V Poltorak.

At least 19 recordsLinked to original sources
PubMed2001

Effect of phensuccinal on pancreatic beta-cells in rats with neonatally induced streptozotocin diabetes mellitus.

The effect of phensuccinal, a low-toxic succinic acid derivative, on the function of pancreatic beta-cells in the evolution of absolute insulin insufficiency was studied in rats with neonatally induced streptozotocin diabetes mellitus. Phensuccinal (25 mg/kg body weight) prevented disorders in the secretory response of beta-cells to glucose load at all stages of the study (2, 5, and 14 days after diabetes induction). This effect was realized via stimulation of the regenerative processes in the insulin-producing system of the pancreas and activation of the antioxidant system in diabetic animals.

Animals↗
PubMed2000

Effect of fensuccinal on experimental insulin resistance.

The effects of new antioxidant fensuccinal on dexamethasone-induced insulin resistance in rats were studied. Oral administration of fensuccinal in a dose of 25 mg/kg for 2 weeks prevented basal hyperinsulinemia and insulin insensitivity of peripheral tissues. Fensuccinal also attenuated oxidative stress by decreasing the concentrations of primary and secondary lipid peroxidation products in liver homogenates. The ability of fensuccinal to prevent dexamethasone-induced insulin resistance is probably due to its antioxidant properties.

Aldehydes↗
PubMed1989

[Lateral modulation of the hypoglycemic action of insulin].

The results of the experimental investigation on 15 rabbits are presented here. Hypoglycemic action of the standard exogenic insulin dose strengthened after performing transcerebral lateral electrostimulation on the right side with the weak current impulse.

Animals↗
PubMed1987

[Modulation of the hypoglycemic effect of insulin during lateral transcerebral electrostimulation].

Experiments on rabbits have studied the effect of lateral transcerebral electrical modulations with weak impulse current on hypoglycemic insulin effect. Two series of experiments were performed on 15 intact animals each. Right-sided electrical stimulation in the first series of experiments produced a trend toward a decrease in fasting blood sugar concentration. In the second series of experiments there was hypoglycemic action of a standard exogenous insulin dose. Transcerebral left-sided electrical stimulation caused no such effects. It has been concluded that the modulation of hypoglycemic exogenous insulin effect was possible due to unilateral transcerebral right-sided electrical stimulation.

Animals↗
PubMed1980

[Effect of thyroxine on the adaptive potentials of the pancreatic islet system beta cells].

Functional activity of the pancreatic insulin-producing apparatus during long-term administration of thyroxin high doses was studied in experiments on mature male rabbits. Thyroxin decreased secretory response of beta-cells to glucose when intravenous glucose tolerance test was carried out and to be lesser degree when peroral glucose tolerance test was realized (insulin level in the peripheral blood plasma at various times after glucose injections was significantly lower than in control animals). Carbohydrate tolerance remained unchanged. It retained the hyperglycemic reaction pattern similar to that developing after the infection of guinea-pig antiinsulin serum. An elevation of the sugar-decreasing effect of exogenous insulin was typical.

Adaptation, Physiological↗
PubMedDate not supplied

[The influence of effective treatment of diabetes mellitus and obesity on the plasma concentration of immunoreactive insulin].

A study was made of 16 patients with the initial mild form of diabetes mellitus in whom the immunoreactive insulin (IRI) indices in glucose loading pointed to a good reactivity of the beta-cells of the insular apparatus of the pancreas. As a result of the dietetic treatment or therapy with saccharolytic oral preparations diabetes proved to become compensated but the IRI indices were unchanged. In patients with adiposity there was seen an increase in the concentration of blood IRI and a reduction of the reaction of beta-cells to the administration of glucose. A course of treatment by dosaged starvation (a loss of weight by an average of 11.5 kg) caused no improvement in the IRI indices was less pronounced, and the treatment by diet with limited caloric value led to improvement of the IRI indices.

Adolescent↗
PubMedDate not supplied

[Effect of phensuccinal on lipid metabolism, lipid peroxidation, and antioxidant system activity in rabbits with dithiazone-induced diabetes].

A three-month administration of phensuccinal improved glucose homeostasis, decreased the levels of total cholesterol, triglycerides, fatty acids, and low-density lipoproteins in the blood serum, and reduced the lipid peroxidation rate as compared to the untreated diabetic control. In addition, phensuccinal increased the content of the antiatherogenic high-density lipoprotein fraction and the related paraoxonase enzyme activity. The preventive effect of phensuccinal with respect to diabetic dyslipidemia development, together with the antioxidant action, show this compound to be a promising therapeutic means of preventing and/or reducing macrovascular complications in diabetic patients.

Aldehydes↗
PubMedDate not supplied

[Effect of gene db dose on the development of beta-cytotropic and immunotropic effects of long-term glibenclamide administration in C57BL/KsJY mice].

The studies have revealed a modifying influence of gene db on the expressivity of damaging beta-cytotropic effect of long-term sulphanilamide therapy and on the development of autoimmune cell response to antigens of pancreatic islets. It is substantiated as promising to study a significance of individual genes and their doses in determining the variations of reactivity to beta-cytotropic and immunotropic effects of the chemical nature factors.

Animals↗