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V V Ponomarev

Publications and source records attributed to V V Ponomarev.

14 recordsLinked to original sources
PubMed2003

Experimental approach to differentiation of the effects mediated by imidazole receptors and alpha2-adrenoceptors on platelets.

We studied parameters of specific binding for various ligands of imidazole receptors and alpha2-adrenoceptors on human platelets. Pharmacological activity of compounds was evaluated by their effects on platelet aggregation induced by ADP in low concentrations (0.125-1.5 microM). In contrast to alpha2-adrenoceptor agonist norepinephrine inducing reversible aggregation of cells, selective stimulation of imidazole receptors with moxonidine produced a disaggregation effect. The data suggest that human platelets can be used as an experimental test system for screening and study of molecular mechanisms underlying the influence of new compounds.

Adenosine Diphosphate↗
PubMed2003

Pharmacokinetics and pharmacodynamics of a new local anesthetic agent.

We compared the effects of local anesthetics procaine, amethocaine (dicaine), bupivacaine, and a new agent RU-1148 on hydrolytic activity of human plasma butyrylcholinesterase. The butyrylcholinesterase-blocking activity of the test substances decreased in the following order: bupivacaine>amethocaine>procaine>RU-1148. The study of the capacity of these agents to form complexes with human plasma proteins and serum albumin showed that RU-1148 in therapeutic concentrations was transported by human serum albumin,beta-globulin, and acid glycoproteins. Study of the mechanisms of pharmacodynamic interactions between clonidine and RU-1148 demonstrated good prospects of their combined use.

Anesthetics, Local↗
PubMed2002

[Central nervous system damage in inflammatory demyelinating polyneuropathies].

The results of subclinical brain damage study of 20 patients with inflammatory demyelinating polyneuropathy, aged 46.5 +/- 3.7 years, are presented. Eleven patients were diagnosed to have Guillain--Barre syndrome and 9--chronic inflammatory demyelinating polyneuropathy. No clinical systems for central nervous system damage were found. Magnetic resonance tomography defected demyelination foci in periventricular and sub-cortical brain regions in 35% of the patients and diffuse atrophic process--in 55%. Registration of brainstem acoustic-evoked potentials showed bilateral latency increase and a change of a signal shape in 60% of the patients. Possible mechanisms of combined damage of central and peripheral nervous system in this pathology are discussed.

Atrophy↗
PubMed2001

Blood clotting disorders in gestosis and pulmonary mechanisms of their compensation.

We studied blood coagulation system in women with uneventful pregnancy and with gestosis and evaluated the hemostasis-regulating role of the lungs in pregnancy and gestosis. We found a correlation between disorders in the pulmonary fibrinolytic function and severity of gestosis, and demonstrated the role of compensatory pulmonary mechanisms in the maintenance of adequate microcirculation in maternal organism and in the mother-placenta-fetus system. Prognostic and diagnostic criteria of gestosis and its complications are proposed.

Blood Coagulation↗
PubMed1999

[The immunosorption of the cerebrospinal fluid in the treatment of inflammatory demyelinating polyneuropathies].

Immunosorption of cerebrospinal fluid with updated "Pall" immunofilters (Germany) was successfully performed in 3 patients with progressing hormone-resistant Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy. It was proved that clinical improvement in the patients' state correlated with a decrease in the contents of both total protein and immunoglobulins G, A, M in cerebrospinal fluid. It was suggested that the removal of these humoral factors had decreased a degree of inflammatory and demyelinating processes in inflammatory demyelinating polyneuropathies and had improved, thereby, the results of the treatment.

Adult↗
PubMed1996

[Chronic inflammatory demyelinating polyneuropathies].

A chronic inflammatory demyelinating polyneuropathy (CIDP) is described both on the basis of authors' own observations and literary data. The disease is characterised by delayed onset with progredient, progredient-remittent and stable course of flaccid paresis of extremity together with mild distal sensitive disturbances, albumino-cytologic dissociation and dysimmunoglobulinemia. Cranial nerves damages and vestibulo-cerebellar disturbances were observed in a number of patients. This confirms the involvement of CNS in CIDP. The common character of clinical, immunological, laboratory and electrophysiological findings permits to consider CIDP and Guillain-Barré syndrome as autoimmune diseases. Meanwhile some recent findings on the formation of antibodies to peripheral nerves structures as well as high titers of antisulfamide and antigangliosides antibodies permit to suggest CIDP as separate nosological unit. Additional clinical data and the evaluation of the role of etiological and pathogenetic mechanisms are necessary for the final conclusion.

Adolescent↗
PubMed1990

[Myasthenia].

Explore the source record for details and available documents.

Combined Modality Therapy↗
PubMedDate not supplied

[A case of diagnosis of Landry ascending paralysis of herpetic etiology].

One clinical and pathomorphologic case of Landry paralysis with a proven etiological role of herpetic infection is reported. Acute clinical syndrome developed as a manifestation of exacerbation of chronic inflammation in the central nervous system. Advancement of the process and generalisation of herpetic infection was connected with immunodeficiency in this patient.

Adult↗