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Biomedical subjects

V V Popova

Publications and source records attributed to V V Popova.

16 recordsLinked to original sources
PubMed2006

[The immunity during the pre-clinical period of type I diabetes mellitus].

The purpose of the study was to investigate the condition of immunity (blood lymphocyte immune phenotype and ultrastructure) in healthy children with a family background of type 1 diabetes mellitus (DM 1) having or not having diabetes-associated autoantibodies (DAAB). The subjects of the study were divided into three groups. Group 1 consisted of 90 children with a family background of DM 1 (first line relatives had DM 1), DAAB- (GADA, IA-2A, and IAA) positive or negative; group 2 consisted of 51 children with newly revealed DM 1; group 3 included 45 healthy controls, normoglycemic DAAB-negative children with no family background of DM 1. GADA, IA-2A, and IAA titers were measured using radioimmunoassay. The immune phenotype of lymphocytes (CD3+, CD4+, CDr8, CD20+, and CD56+ cells) were studied using flow cytometry (FACS-analysis); their ultrastructure was studied by means of electron microscopy. The study found a significantly lower total number of T-lymphocytes (CD3+ cells), T-helpers/inductors (CD4+ cells), and natural killer cells (CD56+ cells and large granule-containing lymphocytes) in the DAAB-positive children vs. the DAAB-negative ones and especially the controls. In the DAAB-positive children, electron microscopy found distinct changes in the ultrastructure of CD4+ lymphocytes and large granule-containing lymphocytes (CD56+ cells), which evidences changes in the secretory and cytostatic function. Such changes in the number and ultrastructure of these lymphocyte subpopulations are found in patients with newly revealed DM 1. Thus, immune changes happen in the organism of a healthy person a long time before clinical manifestations of DM 1 develop; these changes reflect a concealed autoimmune process in Langerhans islets. Detection of DAAB plays a significant role not only in studying poorly understood pre-diabetes nature, but also in the development of new, scientifically based methods of its prevention and treatment.

Adolescent↗
PubMed2004

[The use of intraaortic balloon counterpulsation in patients with acute myocardial infarction].

Intraaortic balloon counterpulsation was implemented in 11 patients with acute myocardial infarction and 1 patient with unstable angina. All patients had severe multivessel coronary artery disease. In 9 patients counterpulsation was used in conjunction with percutaneous transluminal coronary angioplasty, in 3 - with thrombolytic therapy. During hospitalization 2 patients died of progressing heart failure, while significant improvement of hemodynamic parameters occurred in other patients. Thus intraaortic balloon counterpulsation used in combination with angioplasty and thrombolytic therapy is an easily accessible highly effective method of treatment of cardiogenic shock in patients with acute myocardial infarction

Angioplasty, Balloon, Coronary↗
PubMed2003

[Content of different cytokines in the blood of healthy children and their siblings who are either.positive or negative for diabetes-associated autoantibodies (GADA, 1A-2A, IAA)].

Content of different cytokines (IF alpha, TNF alpha, IL-1 alpha, IL-4, IL-6 and IL-10) was examined in the blood serum in two groups of healthy children-siblings with type 1 diabetes mellitus with and without revealed insulin autoantibodies against pancreatic islets (GADA, IA-2A and IAA) by enzyme-like immunosorbent assay (ELISA). In the group of patients with two and more revealed autoantibodies the higher indices in the number of IF alpha, TNF alpha and IL-6, and the decrease in the level of IL-4 comparing with the group of children with negative reaction to diabetes associated autoantibodies were more often observed.

Adolescent↗
PubMed2002

[Lethal outcome in a patient with pulmonary hypertension and liver cirrhosis on the 12-th week of pregnancy].

A patient with pulmonary hypertension and focal liver cirrhosis was hospitalized on the 12-th week of pregnancy because of threatened abortion and died after 2 days of hospital stay during which symptoms of portal and pulmonary hypertension progressed, decompensation of pulmonary heart and hepatic cellular insufficiency ensued and syndrome of disseminated intravascular coagulation developed.

Adult↗
PubMed2000

[Blood plasma level of insulin and sensitivity to it in tissues of patients with newly detected diabetes mellitus type II].

Type II diabetes mellitus is the most common type of the condition. But little is yet known about mechanisms responsible for its development in persons with different body masses. We studied blood plasma levels of insulin and assessed sensitivity to it in 32 patients with freshly detected type II diabetes mellitus with normal and above normal body weight. Of these, 20 subjects were obese, the other 12 being not fat; the control group comprised 30 persons obese and non-obese, with n = 15 and 15 respectively. Recordable in patients was a marked elevation of blood plasma level of insulin accompanied by decrement of the peripheral tissue sensitivity to it in obese diabetic patients while in those persons with normal body mass there was a substantial reduction in the production of insulin, which differences may indicate different pathogenesis of development of type II diabetes mellitus in persons with different body masses.

Body Mass Index↗
PubMed1997

[Kidney involvement in hereditary osteo-onychodysplasia].

Review of the literature and case report concern renal damage in hereditary osteo-onychodysplasia (nail-patella syndrome). This syndrome is a rare genetic disease inherited by the autosome-dominant type. It arises because of underdevelopment of tissues of mesodermal and ectodermal origin and is characterized by hypoplasia or absence of patella, ulnar dysplasia, nail plate dystrophy, growths on the iliac bones, renal affection. The disease was detected in early childhood. Renal affection presented with urinary syndrome with a concurrent nephrotic syndrome later on followed by moderate arterial hypertension and progression to renal failure. Renal biopsy revealed the picture of focal segmentary glomerular hyalinosis typical for this disorder. Because immunodepressants were thought inadequate, the treatment included lovastatin and inhibitors of angiotensin-converting enzyme to inhibit non-immune mechanisms of the disease progression.

Adult↗
PubMed1991

[Burden of monogenic hereditary pathologies of the residents of Ashkhabad in the Turkmen SSR].

The results of medico-genetic investigation of population of Ashkhabad city are presented involving 229 thousand individuals (118230 Turkomans, 94050 Russians and 16720 subjects of other nationalities). Aggravation values the ethnic groups studied are as follows: Turkomen--AD (autosome-dominant = 0.86 per 1000 subjects, AR (autosome-recessive) = 2.31 per 1000 subjects, attached X chromosomes = 0.52 per 1000 males; Russians--AD = 0.93 per 1000 subjects, AR = 0.84, attached X chromosomes = 0.17 per 1000 males; other nationalities AD = 0.81, AR = 1.43, attached X chromosomes = 0.27. Aggravation of the urban Turkomen population is more valid than that of rural people. Relationship between non-accidental inbreeding rate and aggravation with autosome-recessive pathology is shown for several ethnic subdivisions of the population studied.

Ethnicity↗
PubMed1985

[Various indices of metabolism and non-specific immunity in cancer of the thoracic region of the esophagus].

Studies on protein and carbohydrate metabolism in 100 esophageal cancer patients showed a correlation between changes in metabolism, on the one hand, and stage, site and macroscopic pattern of tumor as well as degree of dysplasia, on the other. Metabolic indexes were shown to return to normal two years after resection of the esophagus and esophagoplasty using small intestine. A study involving 42 patients demonstrated that such parameters of non-specific immunity as complement activity and index of complete phagocytosis undergo maximum changes, viz. a decrease by 66.0 and 41.1%, respectively.

Adult↗
PubMed1984

[Late results of esophagoplasty in cicatricial strictures].

The remote results following the small intestine esophagoplasty in 110 out of 211 patients subjected to the operation are described. The artificial esophagus diseases were found in 24%. Methods for the treatment and prevention of the disease of the artificial esophagus are proposed.

Adolescent↗
PubMedDate not supplied

[Bicarbonate calcium mineral water with carbon dioxide in rehabilitation of children with dismetabolic nephropathies complicated by renal inflammation].

A renal function was studied in children with dismetabolic nephropathy and renal inflammation before and after spa treatment with low-mineral water from the spring "Gornovodnoye". Drinking the water resulted in intensification of 24-h diuresis in increasing proportion of sodium and chlorine ions concentrations and decreasing proportion of calcium and magnesium ions concentrations. A membrane-stabilizing action of Gornovodnenskaya mineral water reduced oxaluria and uraturia. An effective scheme of balneotherapy is proposed.

Bicarbonates↗
PubMedDate not supplied

[Thermally-induced changes in structure-kinetic properties of lactate dehydrogenase].

Structural and functional properties of the lactate dehydrogenase modified by temperature at range 40-70 degrees C have been investigated. Kinetic principles of the thermoinactivation have been studied. The rate constants and the activation energy have been determined. Analysis of changes of the protein molecular mass leads to the conclusion that high-temperature denaturation of the lactate dehydrogenase (in investigated temperature interval) depends on oligomer molecule dissociation to monomers and subsequent aggregation of protein subunits.

Animals↗