Therapeutically, magnesium salts represent an important class of compounds and exhibit various pharmacologic actions. Examples of magnesium salts are ionic magnesium and magnesium citrate in nephrolithiasis, magnesium salicylate in rheumatoid arthritis, magnesium hydroxide as an antacid as well as a cathartic, and magnesium mandelate as urinary antiseptic. Various anions attached to the cation magnesium, such as oxide, chloride, gluconate, and lactate, affect the delivery of the amounts of elemental magnesium to the target site and thereby produce different pharmacodynamic effects. This review examines the bioavailability and pharmacokinetics of various magnesium salts and correlates pharmacodynamic action with the structure-activity relationship.

Biological Availability↗

PubMedDate not supplied

Inhalation therapy: new delivery systems.

The objective of this article is to provide an overview of recent advances in inhalation drug delivery. Problems, advantages, limitations, and developments encountered by different inhalation devices and the agents used in these for the purpose of pulmonary delivery are discussed. A critical appraisal is presented and finally the future directions especially in research of the inhaled therapeutics and aerosols are described.

Administration, Inhalation↗

PubMedDate not supplied

Safety assessment of injectable neomycin in calves.

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Animals↗

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Studies of serum gentamicin disposition after parenteral administration in ewes.

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Animals↗