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Biomedical subjects

V V Rybachkov

Publications and source records attributed to V V Rybachkov.

At least 19 recordsLinked to original sources
PubMed2005

[Complicated gastroduodenal ulcers].

The results of the treatment of 2384 patients with gastric and duodenal ulcers are analyzed. It is demonstrated that over last years the number of complications has increased: perforations -- 2.6 fold, and bleedings -- 7 fold. Markers of a destructive injury of gastric and duodenal mucosa (helicobacter contamination, immunological disorders, level of tumor necrotic factor alpha, indices of catabolism of connective tissue) were studied. It is revealed that such disorders have direct influence on destruction of gastric and duodenal wall manifesting as life-threatening complications.

Antigens, CD↗
PubMed2005

[Principles of determination of surgical policy in general peritonitis].

Based on clinical examination and analysis of treatment results of 575 patients with general peritonitis, the most informative factors were determined which predict lethal outcome, progression of peritonitis and help choose the most effective surgical policy. It is demonstrated that conventional treatment is preferable in the interval of perioperative score of APACHE II from 0 to 10, and programmed sanation relaparotomies -- from 11 to 15. Data about efficacy of total intestinal decompression and peritoneal-enteral lavage, and also methods of mathematical prediction of postoperative complications and outcomes are presented. Prognostic value of individual symptoms, different degree of organs dysfunction and SIRS criteria in early postoperative period were determined.

APACHE↗
PubMed2005

[Neurohumoral changes in acute intestinal obstruction].

Neurohumoral changes were studied in 431 patients with acute intestinal obstruction and in experiments in 165 small laboratory animals with the model of small intestine ileus. The results were obtained on the basis of estimation of the concentration of catecholamines, acetylcholine-like substances, serotonine, histamine, their metabolism products in blood plasma and of the cardiointervalography data. The neurohumoral changes were shown to appear as early as the initial stage of the disease and to be progressing when the disease period became longer. The prevailing sympathetic activity was dependent on the decreased acetylcholine-like substances in blood plasma and tissues. The serotonine and histamine metabolism changed depending on the stage of the disease.

Acute Disease↗
PubMed2003

[Directed therapy in complex treatment of lower limb diabetic angiopathy].

Clinical efficiency of directed therapy was assessed for 312 patients with distal type of lower limb diabetic angiopathy. Methods of directed therapy included indirect electrochemical detoxication, hemosorption and their combination. It was shown that while successful rate of conventional conservative therapy does not exceed 50%, hemosorption and indirect electrochemical detoxication can increase this rate by 5-35%, depending on the initial severity of lower limb ischemia. Directed therapy improves peripheral circulation and attenuates regional toxemia. Optimal results were achieved for combination of hemosorption and indirect electrochemical detoxication: treatment was effective for 87% of patients with 2-grade disease and for 73% - with 3-grade. One can speculate that synergic clinical effect may be attributed to functional normalization of antioxidant system. In conclusion, advantages of directed therapy comparing with conventional conservative treatment lie in its higher efficiency and prolonged therapeutic effect.

Aged↗
PubMed2000

[Mechanism of action of paravasal infiltration].

In order to study the mechanisms of action of paravasal infiltration the content of middle mass molecules and general thiol groups in the central and regional blood flow were studied in 65 patients with obliterating atherosclerosis. The relationship between the stage of extremity ischemia and concentration of general thiol groups was shown.

Aged↗
PubMed1991

[The prognosis of the course of endogenous intoxication in emergency surgery].

On the basis of an analysis of 256 patients with diffuse peritonitis, destructive pancreatitis, mechanical jaundice and purulent cholangitis and complex investigations it was established that the degree of clinical manifestations of endointoxication corresponded to a definite degree of disorders of the central nervous system. The most adequate indices of the course and prognosing the toxic process are thought to be the level of the leukocytic index of intoxication, the prothrombin index, the degree of monocytopenia and proteinuria. Their dynamics reflects changes of the concentration of toxic intermediary metabolites and main characteristics of electron paramagnetic resonance of blood plasma.

Electron Spin Resonance Spectroscopy↗
PubMed1987

[The structure of endotoxemia in peritonitis and means of eliminating it].

An examination of 43 patients has revealed 11 toxic compounds of intermediary metabolism (aldehydes, methylizocyanide, ethanol, aceton etc.) whose concentration in blood became several tens times higher. Their accumulation was most considerable at the decompensation phase. It was shown that hemosorption and hyperbaric oxygenation made the concentration of toxic substances lower.

Acetone↗
PubMed1985

[Endogenous toxicity in acute hepatic failure and ways of eliminating it].

The structure of causes of the endogenous intoxication in 39 patients with acute hepatic insufficiency is studied. Eleven toxic compounds of an organic nature were found responsible for genesis fo the disorders and outcomes of acute hepatic insufficiency. Possible use of hemosorption and hyperbaric oxygenation for the elimination of toxic products is analysed. A combination of them is proved to be expedient. The selectivity of sorption for each toxin separately in various types of hepatic insufficiency is established.

Acute Disease↗
PubMed1981

[Blood plasma kinin system status in mechanical jaundice and means for its correction].

The state of the kinin system in mechanical jaundice and possible ways for its normalization were analysed on the basis of clinico-experimental observations. In 32 patients with postoperative hepatic insufficiency developed against the background of mechanical jaundice a considerable activation of the kinin system was detected which was found to have a direct correlation with the severity of the disease. In experiments on 185 albino rats with model of mechanical jaundice during 40 days a comparative analysis of the state of the kinin system in the initial state, under conditions of hyperbaric oxygenation (HBO) and when using kontrikal and sodium salicylate against the background of HBO was made. The phasic activation of the kinin system was established. The use of HBO was found to maintain the antikinin activity during 30 days of jaundice. The effect of normalization was increased by the simultaneous use of sodium salicylate.

Adult↗