PubMed Health⌕ Search

Biomedical subjects

V V Serov

Publications and source records attributed to V V Serov.

At least 19 recordsLinked to original sources
PubMed1995

[New data on clinico-morphological heterogeneity of chronic glomerulonephritis].

Many years' experience in studying chronic glomerulonephritis allows the author to consider it to be a group entity including mesangioproliferative, mesangiocapillary and sclerosing (fibroplastic) types of glomerulonephritis. Minimal changes, focal segmental glomerular sclerosis/hyalinosis, membranous nephropathy which have been previously included to a group of chronic glomerulonephritis should be excluded since they comprise another group of non-inflammatory glomerulopathies with primary podocytic damage. A group of mesangioproliferative glomerulonephritis (MPGN) is heterogeneous both in terms of pathogenetic parameters, on the one hand, and clinical and predictive parameters, on the other. Their clinical and morphological variants which differ with the nature of immunoglobulins in the glomerular immune complexes are presented as IgA-, IgM-, and IgG-MPGN, each of them pretends to an individual nosological entity. Mesangiocapillary glomerulonephritis (MCGN) as a nosological entity showing specific features of morphological, pathogenetic, and clinical manifestations and prognosis may be left only if dense deposit diseases are deducted, which owing to clinical, morphological and some pathogenetic features pretends to its independence. The morphological types of MCGN are either types (I and III) or form phases (I and IV) which reflect the progression of the disease. Sclerosing (fibroplastic) glomerulonephritis is an evolutive form which completes both MPGN and MCGN. There is strong evidence for the fact that the current nephrology concepts of nosological entities require reconsideration on the basis of new research findings.

Antigen-Antibody Complex↗
PubMed1995

[Interstitial lung diseases--the clinical aspects of the problem].

Upon analysis of 550 cases of different chronic diffuse pulmonary diseases included in a group of interstitial diseases of the lungs (IDL) the authors came to the conclusion that IDL incorporate such variants as alveolitis, pulmonary vasculitis and pulmonary hemorrhages; granulomatosis covers exogenic allergic alveolitis, alveolitis in chronic active hepatitis; vasculitis group includes such rare diseases as necrotizing sarcoid granulomatosis vasculitis and lymphoid granulomatosis; fibrosing alveolitis--secondary alveolitis in sclerodermia systematica, rheumatoid arthritis, Sjogren's disease, chronic active hepatitis. Knowledge of IDL etiology (environmental, occupational, induced by radionuclides, drugs, viruses, fungi) with focus on drug affection of the lungs is thought of value. Biopsy and bronchial lavage findings are compared clinically and morphologically. Mechanisms of pulmonary fibrosis and approaches to inhibition of pulmonary fibrosis progression are outlined.

Adult↗
PubMed1993

[The hepatitis B virus as a probable etiological factor in Sjögren's disease].

Various profiles of serum HBV markers (HbsAg) were identified in 16 patients, markers of active replication in 4 patients (HbeAg, 2 cases; HBcAb IgM, 1 case; HBcAb IgM and HbsAg IgM, 1 case) out of 22 patients with Sjögren disease (SD) having serum HBV markers and systemic manifestations. Of these 3 had a history of acute viral hepatitis, 12 were previously at risk to be infected with hepatitis viruses, 7 had neither the disease nor its risk factors, none of them had chronic active hepatitis or hepatic cirrhosis, 7 exhibited clinical signs of pseudolymphoma, 1 had serum monoclonal IgM kappa in the presence of HBV active replication markers (HBsAg IgM, HbcAb IgM). The present and previous data (on association of SS with chronic active hepatitis and hepatic cirrhosis due to HBV) suggest the involvement of the virus in SD etiology.

Adult↗
PubMed1993

[Clinico-morphologic correlations in various types of mesangiocapillary glomerulonephritis].

The possibilities of the transformation of one type of mesangio-capillary glomerulonephritis (MCGN) into another one are studied on the basis of light microscopic and ultrastructural examination of 100 renal biopsies, immunohistochemical reactions and clinical data analysis. Apart from the universally adopted I, II, III and IV types of MCGN, a new type is distinguished which occupies an intermediate position between types I and IV. The degree of clinical manifestations in this type correlated with the progression of morphological changes. Thus, lobular glomerulonephritis (GN) is an evolutive form of MCGN. With the progression of MCGN, the enhancement of severe nephritically-hypertensive forms is noted clinically, domination of the maximally active and active nephritic forms.

Biopsy↗
PubMed1993

[Extracellular matrix in various forms of ulcerated stomach cancer, their differential diagnosis and morphogenesis].

Immunohistochemical study of the extracellular matrix in ulcerated stomach carcinoma has been performed. Material is taken from 70 patients having either ulcerated or non-ulcerated carcinoma, and from 10 patients with chronic stomach ulcer. Results of the study revealed additional criteria for a differential diagnosis of various forms of ulcerated stomach carcinoma and gave a description of their morphogenesis.

Diagnosis, Differential↗
PubMed1993

[Glomerular permeability for serum proteins in different morphological types of primary chronic glomerulopathy].

Membranous glomerulonephritis (MGN), mesangiocapillary (MCGN), membranoproliferative glomerulonephritis (MPGN) and focal segmental sclerosis or hyalinosis (FSSH) were studied for glomerular filter permeability to serum albumins, IgA and IgG. In MGN the permeability for large-molecular globulins is not dependent on that for albumin, permeabilities for the globulins appeared correlated. In MPGN permeability for IgG depends on albumins permeability, correlations between that for IgA and IgG are similar to relevant findings in MGN. In MCGN glomerular permeability for IgA depends on that for albumins, and IgG depends on IgA permeability. In FSSH better albumin permeability implies increased permeability for both globulins, while enhanced permeability for IgA entails the same trend for albumins and IgG. Variable permeability of the glomerular filter for serum proteins in different morphological forms of chronic glomerulopathy may result from dissimilar defects in diverse layers of the filter and in interaction of basal membrane structures with cells responsible for glomerular impermeability for serum proteins.

Adolescent↗
PubMed1992

[Sclerosis and carcinogenesis].

Morphological analysis of the sclerotic changes in peripheral lung carcinoma (PLC) and nephrosclerosis in renal-cell carcinoma (RCC) established a promoting role of sclerosis in carcinoma development. The pneumosclerosis role as a background process in the PLC development is proved by the following facts: high proportion (83%) of the carcinoma in the scar among PLC; identity of the scar collagen composition in PLC and that in metatuberculosis and metapneumonic pneumosclerosis foci; detection of metatuberculosis foci in 75% of PLC; the presence of the precancerous changes in the epithelium entrapped in the pneumosclerotic foci, not only with signs of morphological atypia, but with the disturbance of nuclear DNA and cellular oncogene expression as well. The association of RCC with nephrosclerosis is shown by a high proportion (82.7%) of the RCC development against the background of nephrosclerosis; the dependence of the so-called cortical adenoma development on the degree of nephrosclerosis; epithelial proliferation in the nephrosclerotic foci with the appearance of undifferentiated cells with the altered DNA content and the expression of cytokeratins and vimentine. Carcinoma morphogenesis against the background of sclerosis may be described as follows: development of sclerosis (focal and/or diffuse), the appearance of the focal epithelial hyperplasia in the scar, dysplasia or adenoma and finally carcinoma.

Adenoma↗
PubMed1992

[The prognosis of the accelerated progression of chronic glomerulonephritis].

Based on the data of the 20-year follow-up of 146 patients suffering from intracapillary chronic glomerulonephritis (CGN) verified with the aid of nephrobiopsy, the conclusion was made about the necessity of distinguishing rapid-progressing CGN. In such pattern of CGN, chronic renal failure may occur for up to 5 years since the disease onset. A significant relationship was established between the incidence of rapid-progressing CGN and the morphological and clinical types as well as tubulointerstitial alterations. The clinical types included the active and inactive nephritic, nephrotic and nephrotic-hypertonic types. A regressive analysis made according to the Cox method permitted one to establish that the clinical type of CGN is the most reliable factor of predicting rapid-progressing disease.

Age Factors↗
PubMed1992

[Liver cirrhosis and lymphoproliferative diseases].

Seven patients suffering from liver cirrhosis combined with lymphoproliferative diseases: chronic lymphoid leukemia (n = 4), lymphosarcoma (n = 3) were placed under observation. Viral etiology of liver cirrhosis was established in 4 patients (HBV markers were revealed in the serum in 2 and in liver tissue in 1) and was assumed in 3 patients (the lack in the anamnesis of other hepatotropic factors; multilobular form of liver cirrhosis). In 5 patients, the lymphoproliferative disease was diagnosed 2-30 years after the appearance of the symptoms of chronic diffuse liver disease. In 2 patients liver cirrhosis and hemoblastosis showed up simultaneously. The role of hepatitis viruses, HBV in particular, in the onset of lymphoproliferative diseases is under discussion.

Adult↗
PubMed1992

[Autoimmunization and autoimmune diseases].

Autoimmunization is understood as a type of immune reactions to the unchanged autoantigens only. Autoimmune processes can be subdivided into the physiological ("sanitary" and regulatory) and pathological ones. Physiological processes are of importance in supporting natural immunological tolerance while pathological processes develop on the basis of the physiological ones in presence of various defects of suppressive mechanisms of the immune system. Pathological processes are the basis of the autoimmune diseases and diseases with secondary autoimmune disturbances. The distinction between organo-specific and organo-nonspecific autoimmune diseases can be taken as their preliminary tentative classification.

Antigen-Antibody Reactions↗
PubMed1992

[Clinical pathology due to hepatitis B virus].

All information accumulated during last 10 years allows the view on the alterations produced by hepatitis B virus as ubiquitous. Extrahepatic pathology in hepatitis B is associated with the immunocomplex and immunocellular mechanisms but more frequently with their combination. Wide spread of hepatitis B virus infection and high level of morbidity, persistence of the virus in the organism necessitate further study of clinical pathology associated with this virus.

Antigen-Antibody Complex↗