Biomedical subjects

V V Shestakov

Publications and source records attributed to V V Shestakov.

15 recordsLinked to original sources

PubMed1999

[The alterations of lipid spectrum in patients with migraine].

The paper presents lipid spectrum in 40 patients aged 19-50 years with migraine. Migraine is one of the possible causes of stroke development at young age. There were found significant atherogenic changes of blood serum lipid spectrum, which didn't depend on clinical peculiarities of the disease, but became more pronounced as far as the level of the situational anxiety (according to Spilberger's questionnaire) increased. It is suggested that the changes in lipid spectrum may be some components in complex alterations of the functions of structures of limbic-reticular complex and humoral-endocrine homeostasis which are both genetically determined and acquired. These changes are quite important in pathogenesis of migraine and may be considered as the risk-factors of the development of cerebral stroke at young age.

Antibody Formation↗

PubMed1994

[Migraine and epilepsy: clinical comparisons and the characteristics of the cerebral blood circulation].

Clinical, electroencephalographic, rheoencephalographic and linear cerebral circulation findings were compared for 71 epileptics (group 1), 62 migraine patients (group 2) and 6 patients with epilepsy which had developed in the presence of severe migraine with aura (group 3). One-third of migraine patients, mostly of young age, suffering from migraine with aura and basilar migraine had such consciousness disorders as stupefaction and syncopes. EEG changes in migraine patients were considered nonspecific, paroxysmal spike activity arose only in addition of epileptic seizures. Cerebral blood flow measured by radionuclide tracing in migraine-free interval tended to speeding up, while in groups 1 and 3 hemocirculation was slow. Epileptogenic provocation in group 1 patients accelerated cerebral blood flow on the side of the focus, but decelerated it in group 3. The authors hold that the nature of migraine and epilepsy is different. By disintegration of cerebrovascular regulation and vascular supply of the neuron, migraine may promote secondary epileptogenesis.

Blood Flow Velocity↗

PubMed1992

[Complications of surgery on the pancreas].

The authors carried out 198 various operations for chronic pancreatitis and carcinoma of the pancreas. Postoperative complications occurred in 105 (53%) patients. Twenty-four (12%) patients died. Right resections of the pancreas were complicated by incompetence of the stump sutures when the remaining part of the gland was large and its tissue changed mildly. In left resection the stump of the gland was sutured completely after wirsungography and complete assurance that the pancreatic duct was not obstructed. In impaired patency of the duct pancreato-digestive anastomoses were established. Tampons and tubes were left in the abdominal cavity in 95-97% of pancreatic resections. Healing occurred through the formation of pancreatic fistulas which closed under the effect of nonoperative treatment.

Chronic Disease↗

PubMed1991

[Characteristics of cerebrovascular circulation and its regulation in early stages of cerebrovascular disorders].

Cerebral circulation studied in 121 patients with early signs of cerebrovascular insufficiency exhibited typical asymmetric slowing down which started in distal compartments of the cerebral vascular bed and advanced to predominance in the vertebrobasilar circulation. Autoregulation of the circulation was preserved though hemodynamic requirements of emotional, mental and physical activity were not met completely. Initial discirculatory encephalopathy involves generalization of dysgemic shifts with progressive circulatory slowing down along the internal carotid arteries. In this case autoregulation gets disturbed in inhibited cerebrovascular reactivity.

Adult↗

PubMed1990

[Changes in cerebral blood circulation and their correction in the interparoxysmal period of epilepsy].

The linear cerebral blood flow (LCBF) was explored in 75 patients with epilepsy according to 131I-albumin transition. LCBF acceleration on the side of the focus, during which the attacks occur rarely and the background EEG remains unchanged is regarded as the most adequate LCBF. The grave course of epilepsy is associated with a decrease of the LCBF on the side of the focus. The pattern of LCBF alterations depends as well on the form of epilepsy. Subclinical activation of the epileptic focus by corasole or hyperventilation gives rise to an increase of the LCBF on its side in patients with generalized secondary epilepsy, to a lowering in temporal epilepsy, and the lack of dynamics in the precentral disease pattern. Correction of the hemodynamic disorders can be attained with the aid of combining phenobarbital and caffeine or papaverine. The pathogenetic importance of the hemodynamic disorders is discussed in connection with functional hypoxia of neurons.

Adolescent↗

PubMed1989

[Psycho-autonomic correlations in patients with neuroses and in persons with risk factors of cerebrovascular disorders].

Psychovegetative correlations were made in 78 patients with neuroses and in 72 normal persons working under the conditions of emotional stress. The characteristics of emotional and vegetative responses have been delineated in patients with the well-defined syndrome of vegetodystonia and in persons working under the conditions at risk for the development of neurotic and vascular disturbances.

Adolescent↗

PubMed1987