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Biomedical subjects

V V Subbarao

Publications and source records attributed to V V Subbarao.

5 recordsLinked to original sources
PubMed1990

Symptomatology and hormone profile of menopausal Nigerians.

The alterations in the hormonal levels during menopause have been studied in Nigerian women. There is a significant decrease in oestradiol level of early menopausal and late menopausal women while the testosterone level increased (P less than 0.01). The luteinizing hormone (LH) and follicle-stimulating hormone (FSH) showed significant elevation (P less than 0.01). The elevation of FSH is about 14 times higher in early menopausal women and 16 times higher in late menopausal women when compared to the level in the control. LH, however, showed an elevation eight times higher in early menopausal women and 12 times higher in late menopausal women. The level of these hormones, the intensity of climacteric symptoms among menopausal Nigerian women and attainable age of menopause were found to be the same as in Caucasians.

Aged↗
PubMed1982

Effect of Liv-52 on carbon tetrachloride-induced changes in hepatic microsomal drug-metabolizing enzymes of the rat.

The effects of the hepatotonic Liv-52 on carbon tetrachloride (CCl4)-induced changes in the activities of the microsomal enzymes, aniline hydroxylase, p-aminopyrine N-demethylase and aryl hydrocarbon hydroxylase (AHH), have been investigated. Treatment with Liv-52 (before or after CCl4 administration) markedly decreased, the CCl4-mediated reduction in aniline hydrochloride and p-aminopyrine N-demethylase activities, although the decrease in AHH activity could not be prevented. Kinetic studies showed that the effect of Liv-52 was not due to an alteration in the Km values of the enzymes. The possible mechanism by which Liv-52 moderated the CCl4-induced changes in the microsomal drug-metabolizing enzymes is discussed.

Animals↗