[The systems approach in space biology and medicine].
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Aerospace Medicine↗
Biomedical subjects
V V Verigo
Publications and source records attributed to V V Verigo.
[Mathematical model of the immunostimulation of tumor growth].
A mathematical model of immune system that takes into consideration the subpopulation of suppressor lymphocytes was proposed. The possibility of stable balance in the process of carcinogenesis is shown. The prospects of mathematical formalization of the immune processes are discussed.
Humans↗
[Method of mathematical description of the dynamics of cell population density].
The paper presents a method of building a mathematical model of the time dynamics of the cell population density and mitotic index which allows the prediction of the population growth as related to the cultivation conditions. The process of mammalian cell division has been shown to delay noticeably with a decrease of the cultivation temperature from 36 to 30 degrees C and an increase of the initial population density. The curve of the population density has a typical sigmoidal pattern.
Cell Division↗
[Mathematic modeling of the processes of water and salt metabolism].
This paper describes mathematical modeling of fluid-electrolyte metabolism and fluid homeostasis in real and simulated microgravity. At the first stage physiological reactions to provocative tests were simulated. The assumptions made yielded satisfactory results, particularly with respect to the excretion of the most important electrolytes in different time intervals of bed rest and recovery. The development of models of fluid homeostasis, taking into consideration tissue elasticity and plasticity and fluid buffering capacity, is discussed.
Blood Physiological Phenomena↗
[Phasic processes in the kinetics of the formed elements of the blood].
When quantitating blood shifts in response to environmental effects, it is important to take into account the phasic pattern of certain processes. Theoretical considerations and experimental data on the fluctuations of the counts of formed elements have been published. Since the fluctuations cannot be easily detected by experimental methods, they can be investigated using mathematical modeling. A model describing the counts of red blood cells and their precursors in relation to the age structure of the population has been developed. Depending on the oxygen requirements and physiological parameters, humoral regulation controls cell proliferation and release into the functioning pool. The model allows for incidental hemolysis as well as for life-time of red blood cells. Simulation of various processes in the blood system when exposed to unusual environmental effects has shown that some of the processes can be phasic in character.
Adaptation, Physiological↗
[Tasks in planning biological experiments].
The paper describes certain cases of using mathematical methods in the planning of biological experiments. The paper presents an algorithm of the distribution of the experimental data based on dynamic programming. The paper discusses an application of computer-aided calculations for the formation of homogeneous groups of experimental and control tests.
Animals↗
[Mathematical model of the postradiation recovery of the hematopoietic system].
The paper describes a mathematical model of hemopoiesis that takes into consideration postradiation arrest of mitoses and the stimulatory effect of a lack of functional cells on the yield of dividing cells into the maturing pool. Computer-aided modelling shows good agreement with the experimental data.
Bone Marrow↗
[Basic purposes and results of a radiobiological experiment on the "Kosmos-690" biosatellite].
In 1974 the USSR carried out a rat experiment aboard the biosatellite Cosmos-690 equipped with a gamma-emitter. On the 10th flight day rats were irradied with doses of 220 and 800 rad. During the subsequent 10 days radiation damage developed. Similar experiments simulating the flight profile, except for weightlessness, were conducted on the Earth. The resulting data were compared. It is concluded that a short-term (up to 20 days) flight did not modify essentially the radiobiological effect.
Animals↗
[Relation of human weight loss to the duration of space flight].
A formula describing weight losses in the first approximation during space mission was derived assuming that humans may adapt to space flight effects. The process depended on two parameters one of which characterized maximum body losses and another--time of adaptation. Weight estimates of Skylab crewmembers obtained with the aid of the formula were in good agreement with actual results. The typical time of adaptation was two days. Possible ways of constructing a more precise model of weight changes and its use to diagnose the status of crewmembers are discussed.
Adaptation, Physiological↗
[Theroretical aspects of the problem of prognosing the state of the human body during space flight].
The paper presents general principles underlying the construction of mathematical systems used to predict the human health status in space flight. It describes methods of prediction based on the concepts of homeostasis and general adaptation syndrome. The paper discusses applications of methods of statistic approximation and expertise estimates to predict changes in different parameters of the Salyut crewmembers. It gives an evaluation of the accuracy with which variations in the heart rate of the Salyut crewmembers were predicted using a linear model and expertise estimates.
Adaptation, Physiological↗