Biomedical subjects
Publications and source records attributed to V V Zaĭtsev.
The article contains basic legal and standard acts on regulating law in health service, rights and responsibilities of patients and doctors. Knowledge of the regulation raises responsibility of otorhinolaryngologists in rendering medical care and must improve quality of ENT service.
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The main cause of cardiac valve bioprosthesis dysfunction is mechanical rupture of the cusps consequent upon the development of "fatigue" tensions and calcification of the biologic tissue. The technology of "Bionix" prostheses manufacturing implies prevention of these complications by means of supporting frameworks of variable rigidity (dumping stroke loads) and the use of a calcinosis inhibitor in the process of chemical stabilization. Experimental research confirms the certain effectiveness of such an approach to solving the problem of bioprosthesis durability. Experience in clinical application of biological valves of this series showed that by the 5th postoperative year the stability of good results was 90.0 +/- 2.2%; absence of thromboembolic complications in 93.3 +/- 2.4%, and no need to operate because of dysfunction of the bioprosthesis in 96.6 +/- 2.1%.
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The article deals with the experience in the clinical use of pericardial xenografts in surgical correction of large ventricular septal defects in babies. Primary closure of the VSD under conditions of hypothermic perfusion at a low volume rate was carried out in 202 children whose ages ranged from 6 weeks to 12 months and body weight from 3.5 to 10 kg. The aorta was not clamped. In 142 patients the defect was closed with xenogenous pericardium treated with 0.6% glutaraldehyde solution on HEPE buffer and 1% sodium dodecyl sulfate solution. A pericardial xenograft treated by Carpantje's method was used before 1985 (59 patients). The hospital mortality rate was 6.4% (13 patients). The mortality rate was 5.1% among patients over 6 months of age and 11% among those under 6 months of age, which is explained by their initially extremely grave condition. The long-term results were studied in 133 patients by bidimensional and Doppler echocardiography. The pressure in the right ventricle was found to be normal (26 +/- 4.3 mm Hg) in all patients. The right- and left-ventricular end-diastolic volumes were normal, just like the ejection fractions (55.4 +/- 6.6 and 57.3 +/- 6.8%, respectively). A small escape of blood at the level of the graft was found in only 5% of patients. Mild incompetence of the tricuspid valve without clinical manifestations was revealed in 18% of patients. In none of the cases, signs of calcinosis or aneurysm of the graft were found, fatal outcomes in the long-term postoperative periods were not encountered.(ABSTRACT TRUNCATED AT 250 WORDS)
The authors analyse the causes of repeated operations on 42 among a group of 157 patients with implanted biological cardiac valve prostheses and a postoperative follow-up period of 3.5 to 13 years. The main cause of dysfunction of biological prostheses is calcification which develops mostly in xenopericardial valves irrespective of their localization. Detachment of the cusps from the frame and their destruction is characteristic of allogeneic prostheses and those formed from the dura mater. Dysfunction of bioprostheses in the tricuspid position develops much later.
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Lactate dehydrogenase was studied in dog's kidney glomeruli using electron microscope. Detection of the enzyme in the podocyte confirms the principle of structural integration of glycolytical enzyme on the membranes.
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The activity of acid phosphotase in the blood serum and punctates of the liver was studied in 49 patients with acute cyclic form of viral hepatitis of slight and medium-grave course with the use of histological and histochemical methods. The degree of manifestation of necrotic changes in the punctate tissue was determined with the help of the stereometric method. As a result of the studies conducted, it was established that the degree of hyperfermentemia was the highest at the period when the disease was in full swing, and that it did not depend on the form of its course and extent of necrotic changes observed in the liver punctates. The authors consider a morphological evidence of high activity of acid phosphotase in the blood serum aggregations of large hepatocytes, cytoplasm of which was loaded with mature lipofuscin, the topographic identity of the latter with acid phosphotase at present being proved.
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The authors discuss questions facing forensic medical experts in connection with civil "medical" actions. The questions are classified as common and private. Expert evaluations of correspondence of the scope and quality of dental care are offered as the base for analysis of these problems within the framework of civil legislation. The data evidence efficiency of forensic medical expert evaluations in civil legal procedure and the significance of forensic medical service in the solution of problems of quality and efficiency of medical (including dental) care of the population.
Direct conversion reading machines for the blind with tactile and acoustic information output were analyzed. It is shown that direct conversion machines are simple enough, inexpensive and may be recommended for individual use. But an effective use of them requires a protracted period of learning. The present state and future prospects for constructing reading machines with vocal information output (machines with letter-wise recognition and the ones capable of synthetizing the speech) are enquired into. These machines are shown to help reach a greater reading speed, but are of a more complex nature.