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Biomedical subjects

V Vísek

Publications and source records attributed to V Vísek.

At least 55 records · Page 3Linked to original sources

First month course of left ventricular asynergy after intracoronary thrombolysis in acute myocardial infarction. A longitudinal echocardiographic study.

Can intracoronary thrombolytic therapy (ITT) reduce the infarct size and improve regional and global left ventricular function and if so how long after recanalization does this improvement develop? 42 patients were treated with ITT, of whom 25 showed successful recanalization (group A) and 17 had persistent occlusion or reocclusion (group B). Both groups were examined five times during the first month after infarction with two-dimensional echocardiography. The 'asynergy index' improved in group A by 45% of initial pretreatment values, compared with no significant change in group B (P less than 0.005). The 'asynergy extent' improved in group A by 35%, while in group B again no change was observed (P less than 0.01). This improvement occurred slowly, significant differences being achieved by the 10th day. Entire normalization of left ventricular wall motion was observed in 5 patients (20%) from group A and in no patient from group B. We conclude that successful recanalization of the occluded coronary artery by ITT improves left ventricular wall motion in 80% of patients, with entire normalization of local function in 20% of cases. The improvement occurs slowly during the first 10 days.

Adult↗

Ultrasound characteristics of myocardial hypertrophy in patients affected by hypertrophic cardiomyopathy.

A study of the extent and local distribution of the heart muscle hypertrophy affecting the left ventricle and the septum has been performed in 70 hypertrophic cardiomyopathy patients. According to these signs the patients have been distributed into 5 types. Type I, where the hypertrophy affected only the interventricular septum, appeared in 14.2% of the cases. In type IIa the anterior wall of the ventricle was simultaneously affected (37.1%), in type IIb it was also the lateral wall of the ventricle (30.0%). Type III manifested hypertrophy of the posterior wall (4.3%), type IV affected the apical portion of the left ventricle (8.5% of the patients). Under the heading of type V there figured patients who had a concentric hypertrophy of the whole left ventricle including the septum (5.7%). Among the obstructive forms we revealed especially the types Ia, IIa, IIb. Using the M-mode alone, detection of the hypertrophy was impossible in such patients who had isolated affection of the dorsal part of the septum, the anterolateral or the apical portion of the left ventricle (type Ib, IV and some of the type IIa and IIb patients--a total of 13%). Signs of asymmetrical septal hypertrophy were lacking in 23% of the patients.

Adolescent↗

Electrocardiography in different types of hypertrophic cardiomyopathies.

Alterations in ECG in hypertrophic cardiomyopathies (HCMP) have been described already earlier when the knowledge of HCMP was not so profound. The aim of this work was to analyse ECG findings in hypertrophic myelopathy and to determine their relation to morphological observations. 76 patients examined echocardiographically with catheterization were performed ECG recordings. Normal ECG had 3 patients (3.9%). In the rest of them electrocardiography confirmed left ventricular hypertrophy (63.2%), large R wave in V1(-3) (14.5%), diminishing of R wave in V1(-3) (28.9%), pathologic Q wave (23.7%), absence of "q" wave in V5,6 (48.8%), ST-T abnormalities (86.7%). Pathologic Q wave was found more often in patients with right ventricular hypertrophy, deep T waves (greater than 10 mm) currently occurred in apical form. It follows that the presence and the range of myocardial hypertrophy cannot be electrocardiographically recorded. Therefore the ECG is applied in great majority of patients only as a screening method.

Adolescent↗

Intracoronary thrombolytic treatment in myocardial infarction and unstable angina pectoris.

The authors report on 18 patients with fresh transmural myocardial infarction (MI) and 5 patients with an abrupt change of stable into unstable angina pectoris (AP), in whom superselective intracoronary thrombolysis (SIT) was performed. All patients with unstable AP showed an improvement of subjective complaints and increased tolerance of exercise, even though a demonstrable angiographic effect of SIT was found only in 1 patient. Coronary occlusion disappeared in 13 patients with MI (72%). A significant improvement of local kinetic disturbances and of the global left ventricular function occurred in 50%, in-hospital death occurred only in the group in which recanalization did not succeed. Emphasis is placed on the necessity of checking the effect of SIT not only by documenting correction, of the coronary occlusion but also by evaluating the size of MI and the extent of disturbances of local and total left ventricular kinetics. The most accurate and practical method for this purpose is two-dimensional echocardiography. The authors developed their own echocardiographic indicators of the infarction focus--asynergy extent and asynergy index.

Adult↗

The role of echocardiography in a coronary care unit.

The purpose of the study was to assess the clinical value of echocardiography in a coronary care unit. 133 patients admitted for an acute cardiovascular disorder were examined by a mobile echocardiograph. 83 patients had an acute myocardial infarction, 8 extracardiac chest pain, 6 unstable angina pectoris, 6 acute pulmonary embolism and 16 other acute cardiovascular diseases. 14 patients were excluded from the study because of poor image quality. Echocardiography was found most advantageous in solving the following clinical problems: 1) early diagnosis of acute myocardial infarction (probably the earliest of all available methods); 2) immediate and precise diagnosis of complications in myocardial infarction; 3) differential diagnosis of chest pain; 4) detection of left ventricular thrombi (the most useful method for this purpose); 5) differential diagnosis of other acute cardiovascular diseases (pulmonary embolism, aortic root dissection etc.).

Acute Disease↗

Possibilities of two-dimensional echocardiography in cardiomyopathies.

Findings in 20 patients with congestive, in 14 with hypertrophic and in one with restrictive cardiomyopathy are described. In congestive cardiomyopathy, there predominated left ventricular dilatation and diffuse hypokinesis with decreased ejection fraction. The main criteria are reported for differentiating it from advanced diffuse ischaemic heart disease. More detailed characterization is presented of the type of asymmetric septal hypertrophy and of the systolic anterior motion of the mitral apparatus and the possible causes of this finding are discussed. In a patient with restrictive cardiomyopathy there predominated a symmetric thickening of the left ventricle, with diffusely decreased kinetics and increased density of all structures.

Adolescent↗

Distribution of hypertrophy in obstructive and non-obstructive types of hypertrophic cardiomyopathy.

70 patients with hypertrophic cardiomyopathy were examined by one-dimensional, two-dimensional and pulsed Doppler echocardiography. According to the degree and distribution of hypertrophy in left ventricular (LV) short axis views, the findings were divided into 5 types. In type I, hypertrophy affected only the interventricular septum (10 patients, i.e. 14.2%). In type II, hypertrophy involved besides the septum, also the LV anterior wall (type IIa-26 patients; 37.1%) or lateral wall (type IIb-21 patients; 30.0%). Type III included patients with hypertrophy of the LV posterior wall (3 patients; 4.3%). Six patients (8.5%) had a distinct hypertrophy of the whole apical part of the LV and septum (type IV). Type V was represented by concentric hypertrophy of the LV and septum (4 patients; 5.7%). Hypertrophy of the right ventricular myocardium was found in 6 patients.

Adolescent↗

Two-dimensional echocardiography in evaluating left ventricular function.

In 65 patients examined by mechanical sector and M-mode echocardiography, left ventricular volumes and ejection fraction were determined. Comparison with biplane ventriculography has shown that the above-mentioned parameters can be determined by sector relatively very reliably. Correlation coefficients for end-diastolic and end-systolic volumes were 0.74 and 0.85 respectively, for the ejection fraction 0.78. Substantially less close correlations were found for parameters obtained by one-dimensional echocardiography, especially in patients with segmental disturbances of kinetics and abnormal left ventricular geometry. The greatest contribution of this laborious and demanding method consists in the possibility of relatively reliable estimation of left ventricular volumes and ejection fraction by two-dimensional echocardiography also in these patients.

Adult↗

Two-dimensional echocardiography in acute transmural and non-transmural myocardial infarction.

Left ventricular wall motion abnormalities in acute myocardial infarction and their changes during hospitalisation were investigated in 40 patients by means of two-dimensional echocardiography (2-D-E). It was confirmed that two-dimensional echocardiography can detect segmental left ventricular asynergy, follow up its development during hospitalisation and provide on the basis of this information on the extent of infarction. Differences were found between transmural and non-transmural infarctions, in particular as regards the duration of impaired wall motion (in non-transmural infarctions it was only temporary). Suggested indicators of the extent of this disorder ("index of asynergy" and "extent of asynergy") seem to be valuable for the evaluation of the extent of infarction and of its clinical impact. The sensitivity and specificity of echocardiography, as compared with postmortem findings, is satisfactory.

Adult↗