Biomedical subjects

V Vardhani

Publications and source records attributed to V Vardhani.

3 recordsLinked to original sources

PubMed1979

Intestinal mast cells during experimental ancylostomiasis.

The alterations of mast cell counts induced in the gut of swiss albino mice by infection with Ancylostoma caninum larvae have been studied, both in single and multiple infections. It was found that mast cell rise was greater in females than males. In singly infected animals, mast cell increase was influenced by the infective dose of inoculated larvae. In case of repeatedly infected mice, mast cell counts were decreased because of their earlier degranulation.

Ancylostomiasis↗

PubMed1979

Pharmacological estimation of histamine in the intestine of mice experimentally infected with single doses of Ancylostoma caninum larvae.

Histamine content of the intestine of young female Swiss albino mice experimentally infected per os with low (500) and high (2000) doses of Ancylostoma caninum larvae was studied. The histamine level increased in both the experimental groups reaching peak values on the 16th day post infection in animals inoculated with a dose of 500 larvae and on the 30th day post infection in animals inoculated with 2000 larvae; the histamine content was 2.5 times higher in the former and 4 times higher in the latter than that in the uninfected controls.

Ancylostomiasis↗

PubMed1978

Rejection of worm load through singly and repeatedly sensitized peritoneal exudate cells during experimental ancylostomiasis.

Sensitized peritoneal exudate cells from Swiss albino mice donors infected with a single dose of 1000 A. caninum larvae could expel a challenge dose of 500 larvae from recipients at a faster rate when compared to cells from repeatedly infected (250 + 250 + 500) donors. However, at 36 h after challenge, the larval expulsion was almost the same in both the groups. Because of the bowel sensitization by the cells, some larvae (not expelled) in the 1st group, readily migrated into muscles where they met allergic immobilization and death due to infiltration of inflammatory cells and their exudates at these sites.

Ancylostomiasis↗