Biomedical subjects
Publications and source records attributed to V Vidmar.
The microgasometric method was used for determination of MAO activity in single odontoblasts isolated from rat and man. By using tyramine as a substrate, the presence of MAO in these cells was demonstrated. Both molecular forms of MAO, MAO A and MAO B, were found using specific inhibitors clorgyline and deprenyl.
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The permeation of barbitone sodium, benzoic acid, and salicylic acid from microcapsules into aqueous medium has been examined at different pH values. The apparent diffusion coefficients of drugs were linearly proportional to the ethyl cellulose/water partition coefficient of drugs, and the straight line parameters were dependent upon volume fractions of water-filled pores (i.e. capsule size), testifying to a previously proposed mechanism of drug permeation. The rate of drug permeation was also a function of the pH-value of the surrounding sink solution; the period of zero order release was longer at low pH because of the change of drug partition or solubility or both.
The volume fraction of the water-filled pores in the microcapsule membranes was calculated and the values from 0.55 to 2.5% were obtained. Differential scanning calorimetry of aqueous suspensions of microcapsules showed no structured water present in the ethyl cellulose membranes. The temperature effect on the apparent diffusion coefficient of a drug was investigated and the apparent activation energy of diffusion was calculated.
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Poly(lactic acid) microcapsules of oxytetracycline hydrochloride were prepared by precipitation of the polymer from a solution when a non-solvent was added to a polymer solution in which the drug had been dispersed. Three types of microcapsules were prepared by varying the amount of drug encapsulated, as well as by using two samples of polymer with different molecular weights. The product obtained was of a matrix character consisting of agglomerated capsules. The drug release in vitro, for the best batch, was completed within 12 hours. Serum levels of the drug in rabbits treated by intramuscular injection were prolonged maximally up to 24 hours depending upon the type of microcapsules.
Poly(lactic acid) microcapsules of pilocarpine hydrochloride were prepared and evaluated by measuring a miotic effect in rabbits. The microcapsule suspension showed prolongation of miosis and an improved bioavailability when compared with a standard eye dosage form.