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Biomedical subjects

V Virmani

Publications and source records attributed to V Virmani.

At least 19 recordsLinked to original sources

Non-familial, spinal segmental muscular atrophy in juvenile and young subjects.

Thirty-two cases of juvenile and adult onset, non-familial, spinal, segmental muscular atrophy seen in two widely separated geographical regions of India were studied over the last 15 years. The characteristic features were: the non-familial, non-endemic nature, the strictly segmental distribution from the clinical and EMG point of view, which involved either distal or proximal segments of one upper or lower extremity, the absence of involvement of cranial nerves of the pyramidal, sensory and autonomic nervous system, the very high male predilection and the very insidious progression. No definitive etiological factors could be incriminated.

Adult↗

Skeletal muscle involvement in tropical endomyocardial fibrosis.

Evidence for neuromuscular dysfunction was sought in 20 consecutive, angiographically proven cases of tropical endomyocardial fibrosis (Group I). Statistical comparison was made with equal number of age, sex and weight-matched normal healthy volunteers (Group II), as well as similarly matched cases of consecutive heart failure (Group III). A myopathic pattern in the EMG was found in 85% of Group I and 65% of Group III patients. However, the severity and global extent of the EMG changes was much more marked in Group I than in Group III. The summed motor unit potential duration was reduced by 20.1% in Group I and by 9.5% in Group III. Corresponding figures for summed motor unit potential amplitude were 27.9% and 15.4%. the summed frequency of polyphasic potentials was significant in Group I and in Group III. Involvement of 3 or 4 muscles in the same patient was found in 80% of Group I, n 10% of Group III. The upper limb muscles were affected in 80% of Group I and 50% of Group III. The motor nerve conduction velocity and distal latency time were normal in all the patients. It is suggested therefore that the myopathic EMG changes in Group I patients may be related to the disease process itself, rather than a reflection of long standing CHF alone. Light-microscopic study of the quadriceps muscles in 8 patients of Group I did not reveal any abnormality.

Adolescent↗

A case of myoclonic epilepsy with unusual presentation.

A case of stimulus-precipitated myoclonic jerks is presented. Besides spontaneous jerks, auditory, stimuli striking the palms, abdominal pressure or distension, evoked the jerks. Intermittent stroboscopic stimulation did not precipitate the attacks. The child had spontaneous recovery which is maintained, clinically and EEG wise for the last one year.

Acoustic Stimulation↗

Cerebral cysticercosis.

Twenty cases of cysticerosis involving the central nervous system were seen during a 6-year period. Twelve patients presented with symptom and signs of raised intracranial pressure, 6 with seizures and 1 each with subacute meningitis and psychosis. The diagnosis of cerebral cysticercosis was established by brain biopsy in 8 patients, at autopsy in 3, and by biopsy of a subcutaneous nodule in 7. It was presumed on the basis of typical intracranial calcification in 1 case and soft tissue calcification in another. The protean clinical manifestations of this condition and the diagnostic difficulties it raises are discussed.

Adult↗

Aspergillosis of the central nervous system.

Aspergillosis of the central nervous system is rare. The spread to the CNS is usually from the lungs and uncommonly from paranasal sinuses. Four cases of CNS aspergillosis with spread of infection from the paranasal sinuses are described. Two patients had meningitis, one intracranial granuloma and one presented with subarachnoid haemorrhage resulting from a fungal mycotic aneurysm. Difficulties in establishing the diagnosis are discussed.

Adolescent↗

Capgras phenomenon in a case of temporal lobe epilepsy.

The present report regarda a patient of temporal lobe epilepsy, who developed the classical features of Capgras phenomenon. The whole clinical picture responded to treatment. The possible roles of organic and psycho-social factors in the psychopathology of this peculiar delusion in this patient are discussed.

Adult↗