Biomedical subjects

V Vondra

Publications and source records attributed to V Vondra.

At least 19 recordsLinked to original sources

PubMed1992

[Prevalence of glucose metabolism disorders and thyropathies in the population of District 8 in Prague].

Based on an enquiry made by means of questionnaires sent by post, implemented in 1987 in five health communities of Prague 8, anamnestic data were obtained pertaining to glycoregulation and thyropathies from 5870 respondents. Based on these data the following conclusions were reached: 1. The prevalence of known disorders of glycoregulation, without specification, is in the population of Prague 8 7.98%. The difference between men and women is not significant. The number of disorders increases with age and higher body weight. A positive relationship was confirmed with anamnestic data on the delivery of a heavy foetus in women. Also the importance of a positive thyroid or diabetic family-history was confirmed. Combination of thyroid disease (without more detailed specification) and allergic disease is frequent. Both these relationships are highly significant. Subjects with higher education and subjects born in Prague report disorders of glycoregulation significantly less frequently than other respondents. 2. The prevalence of thyropathies differs significantly in men (3.60%) and women (16.87%). Disorders increase with age but decline again in the higher age brackets. This is particularly marked in women. There is a significant relationship with the family-history and there is frequent combination with impaired glycoregulation. Combination with allergy is also frequent. In subjects with thyropathies the BMI tends towards a scatter to high and low values. No significant relationship with education, place of birth (Prague and non-Prague) nor delivery of heavy foetus was found in women.

Adult↗

PubMed1992

[Self-treatment and self-monitoring in patients with bronchial asthma].

Regular assessment of the peak expiratory flow (PEF), which after proper instruction, the patient can do himself is important for evaluation of the activity of bronchial asthma. It is, however, essential to assess the optimal PEF values of every individual. For control of self-treatment it is important to know the daily variations of PEF and the degree of reversibility of bronchospasm after inhalation of a beta 2-adrenergic substance. Inadequate reversibility of bronchial obstruction despite repeated inhalation of a beta 2-adrenergic substance is usually caused by inflammation. Depending on the clinical status and changes of PEF the patient can, if properly instructed, start corticosteroid treatment in case of acute deterioration or increase the corticosteroid doses in case of subacute deterioration of the condition. Follow-up of PEF is important also for self-management in case of clinically latent deterioration and during maintenance treatment.

Acute Disease↗

PubMed1990

[Epidemiology of bronchial asthma and bronchial hyperreactivity].

Prevalence of bronchial asthma and bronchial hyperreactivity (BH) was studied in a randomized sample of Prague 8 inhabitants aged 19 and over. The number of adults living in Prague 8 had been 90 458 by December 31, 1987. 8458 questionnaires had been sent to 5 randomly selected districts. Information mainly concerned with respiratory diseases was received from 89.9% persons. Cumulative prevalence (i.e. both contemporary and past) of bronchial asthma was 2.3% +/- 0.3% in both sexes. The cumulative prevalence calculated by way of direct standardization was slightly higher - 2.33% +/- 0.33% (men 2.33% +/- 0.5%, women 2.32% +/- 0.45%). The highest value of 3.6% was found at the age of 21-30 years. Evidence of BH was found in 75% cases of bronchial asthma by means of the inhalation histamine test. In adult population, the BH value was calculated on the basis of distribution of incidence in the healthy population and in persons with respiratory disease and the BH prevalence was found in each group. The BH in total adult population of Prague 8 was 13.7%. This is an alarming figure.

Adolescent↗

PubMed1990

[The prevalence of bronchial asthma in a selected sample of the adult Prague population].

The authors assessed the prevalence of bronchial asthma in 8458 18-year-old and older inhabitants of an economic area in Prague 8. The population of the area up to December 31, 1987 was 90,458 adults. The health communities were selected in a random way to comprise the central as well as peripheral parts of Prague 8. By means of questionnaires information was assembled from 70.9% of the respondents and after supplementation of data by various doctors the scope of information was 89.9% (7605/8458). For detailed examination 902 subjects were selected with "confirmed" and suspect symptoms of asthma. The anamnestic data were analyzed and pulmonary ventilation was examined (flow-volume), and depending on indication, also the provocation or bronchodilatation inhalation test, skin tests, and total IgE. The cumulative prevalence of bronchial asthma was 2.3% +/- 0.3% (174/7605). The highest prevalence values were in subjects under 20 years--3.5% and under 30 years--3.6%. The contemporary prevalence was 2.0% +/- 0.3% (152/7605). Nonatopic asthma was recorded in 54%, atopic asthma in 46% of the subjects.

Adolescent↗

PubMed1989

[Pharmacokinetics and chronotherapy of delayed action theophylline (Euphyllin CR)].

Monitoring of theophyllinaemia in the course of 24 h during treatment with theophylline anhydrate capsules (Euphyllin CR) was used in 20 children (9-15 years) and in 20 adults (18-61 years) with bronchial asthma. The doses used in children were 5.96 mg/kg at 7 a.m. and 10.2 mg/kg at 7 p.m., while in adults the morning and evening doses were similar (4.35 and 4.89 mg/kg). After the first dose in the morning the serum theophylline concentration (STC) did not differ in children and adults (10.4 and 10.5 mg/l). In adults the half-time of absorption was twice as high as in children (0.63 and 0.3 h), as well as the time when the peak theophylline concentration was reached (2.7 and 1.39 h). In children a double dose of the drug at night ensured a STC of 11.2 mg/l and a maximum theophyllinaemia (C max = 13.5 mg/l between 8 p.m. and 6 a.m. (measured by the EMIT method). In adults the values during the night were significantly lower than in day-time (STC: ANOVA test P less than 0.05, C max: T-test P less than 0.01). The percentage fluctuation in individual subjects was small (36-49) interindividual, fluctuations in children and adults were considerable (105 to 207). From the chronoprofile of the pharmacokinetics of Euphyllin CR ensues that at the age of 9-15 years the most important indicators are similar to those in adults and that both groups should be given at night a double dose, as compared with that administered in the morning.

Adolescent↗

PubMed1989

Pharmacokinetics of once-daily theophylline dose following the morning versus evening administration.

The pharmacokinetics of theophylline (Uniphyllin) in blood and saliva was compared after morning and evening administration of a once-daily dose in a randomized cross-over study. Ten bronchial asthma patients received multiple doses of 800 mg theophylline at 8 a.m. and 8 p.m. under controlled food conditions. The precision of the serum concentration prediction from salivary measurements in individual patients was sufficient to obtain identical pharmacokinetic parameters and parallel concentration-time curves. There were no significant differences in the values of mean residence time and area under the concentration-time curves after morning and evening dosing, either in the kinetics of elimination and in the volume of distribution. The fluctuation of concentrations during the dosing intervals was 100% after morning doses and 80% after evening doses. No consistent interference with food was found. Circadian variation in the kinetics of drug disposition after once-daily theophylline administration did not occur. In order to achieve higher therapeutical levels at night and in the morning, the evening dosing seems to be preferable.

Adult↗

PubMed1988

Natural killer and interleukin-2 induced cytotoxicity in asthmatics. I. Effect of acute antigen-specific challenge.

Natural killer (NK) cell activity and interleukin-2 (IL-2) induced cytotoxicity to NK-resistant targets T24 in a group of patients with grass pollen seasonal asthma were investigated. Acute bronchial provocation with this antigen was also performed and blood samples were taken before and 15 min after the maximal clinical response. NK activity was elevated in this group but there was a significant decrease after acute challenge. IL-2 induced cytotoxicity was also increased and declined after antigen challenge. Limiting dilution analysis for minimal frequencies of precursors of the IL-2 induced killer cells was introduced and showed increased numbers of lymphokine-activated killing precursors in this group of patients. These data might indicate the aberrations of the IL-2 system in immediate type allergy but the clinical significance of these findings remains to be determined.

Adult↗

PubMed1979