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Biomedical subjects

V Votava

Publications and source records attributed to V Votava.

At least 19 recordsLinked to original sources
PubMed1995

[Successful prevention of Pneumocystis carinii infection with 1,920 mg of trimethoprim-sulfamethoxazole daily in patients with malignant hematopoietic diseases].

During 1991-94 we treated 51 patients with acute myeloid leukaemias and 3 patients with a myelodysplastic syndrome of refractory anaemia with excess of blasts in transformation. The patients received trimethoprim-sulphamethoxazole (TMP-SMX) 1,920 mg daily as a prophylaxis of Pneumocystis carinii infections and selective decontamination of gastrointestinal tract. The majority of patients received TMP-SMX in their first course of chemotherapy with daunorubicin and cytosine arabinoside. Only one of the 18 patients without TMP-SMX prophylaxis during the first course of chemotherapy developed Pneumocystis carinii pneumonia. That pneumonia was successfully treated by intravenous administration of TMP-SMX 1920 mg four times a day. No other Pneumocystis carinii infection was encountered in all other patients during their clinical follow up or in autopsy material of expired patients. TMP-SMX prophylaxis had to be interrupted in 11 patients due to their suspicious allergic skin reactions, however, TMP-SMX was readministered in all without any skin changes attributable to TMP-SMX during next cycles of chemotherapy. TMP-SMX in a given daily dose of 1,920 mg seems to be a successful prophylaxis of Pneumocystis carinii infections in patients with malignant diseases of hematopoiesis.

Acute Disease↗
PubMed1994

[Ocular manifestations of sarcoidosis].

The authors describe two patients with endogenous uveitis. When investigating the aetiology of the inflammation systemic sarcoidosis was diagnosed. The authors emphasize the necessity of interdisciplinary collaboration during care of patients suffering from this disease.

Female↗
PubMed1991

[Symptoms of diseases of the respiratory system and their importance in diagnosis. Summary and conclusions of research].

The status in the sphere of diagnosis of respiratory diseases and the revealed shortcomings in this area stimulated workers of the First Clinic for TB and Respiratory Diseases to elaborate two investigations, the aim of which was to reveal in the course of the eighties (1983-1988) the most important problems in the diagnostic process and thus contribute to the improvement of the present state. Another task was to record developmental trends as regards the contents of the discipline of pneumology. A relatively large number of patients (2207 subjects) and the period of investigation made it possible to draw some general conclusions. The results proved persisting shortcomings, in particular a slow diagnostic process which e.g. in bronchogenic carcinoma and some other diseases very much restricts effective treatment and in TB there is the danger of infection of the healthy population. From this ensue necessary provisions at all levels of medical care (in particular comprehensive examinations of patients, interdisciplinary collaboration, improved preventive provisions and attention paid to changes in the frequency and clinical picture of lung diseases as a result of different factors).

Aged↗
PubMed1990

The tubular maximum for calcium reabsorption in patients with chronic active thoracic sarcoidosis.

The tubular maximum for calcium reabsorption (TmCa) was evaluated in 52 patients with chronic active thoracic sarcoidosis. Hypercalcaemia was found in five patients (9.6%). The mean serum calcium value of 2.54 +/- 0.18 mmol.l-1 in patients with sarcoidosis was significantly higher than that obtained in the control group (2.42 +/- 0.11 mmol.l-1). The mean TmCa in patients with sarcoidosis (2.11 +/- 0.26 mmol.l-1 glomerular filtrate (GF] was not statistically different from the mean TmCa for the group of healthy subjects (2.18 +/- 0.23 mmol.l-1 GF). Urinary sodium corrected TmCa in both groups of patients was affected in a similar way. Our study demonstrates for the first time that there is no increase in TmCa in patients with chronic active thoracic sarcoidosis. Hypercalcaemia is not a result of an increased TmCa.

Adult↗
PubMed1988

Cell-mediated response to BCG investigated by leukocyte migration test from an agarose droplet.

The modified leukocyte migration test (LMT) from an agarose droplet with the antigen stimulation (by BCG) is proposed in the present work. The BCG concentrations ranging from 1.25 up to 130 mg/l were used to examine 20 tuberculin (PPD) skin test negative and 10 PPD positive patients, which suffered from lung diseases. The optimal concentrations were 6.25 and 25.0 mg/l. The mean index values of a 20 membered control group ranged from 0.7 up to 0.88 when stimulated with the lower BCG concentration, and they were of 0.53 up to 0.69 at higher BCG concentration. In spite of its suitable indicatory properties as to ascertain cell mediated immunity state, the LMT with the BCG were of no use as a tuberculin skin test correlate.

BCG Vaccine↗
PubMed1976

[Cell mediated immunity in sarcoidosis patients].

In vitro tests, lymphocyte transformation tests, and leukocyte migration inhibition tests were carried out on nineteen patients with different stages of sarcoidosis. In all patients there was found a defect of cell-mediated immunity, which was most strongly pronounced in the remission phase of the disease. It is believed that the disturbance of cell-mediated immunity is a result of the disease. It is possible for such a disturbance to be intensified in the further course of disease. It appears that this disturbance may be compensated for by the system of B lymphocytes, through humoral antibodies, because clinical phenomena manifest in the patients and corresponding to the deficiency of immunity demonstrated in vitro could not be observed.

Antibody Formation↗