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Biomedical subjects

V Weimar

Publications and source records attributed to V Weimar.

6 recordsLinked to original sources
PubMed1981

Effects of growth factors on corneal wound healing.

Rabbits received nonpenetrating central corneal knife wounds. Immediately after wounding, a single 2.5 or 5.0 micron dose of mesodermal growth factor (MGF) was applied topically to the wound. Controls were treated with saline. Electron microscopic studies compared the healing responses of the control and treated animals over a 7-day period. MGF was a potent nitrogen for keratocytes in rabbit corneas. The single dose enhanced fibroblast proliferation and metabolic activity. Control wounds were not healed after 7 days, whereas those of treated animals showed complete healing.

Animals↗
PubMed1977

Corneal radiofrequency burns: effects of prostaglandins and 45/80.

Vascularization of the rat cornea was produced by means of radiofrequency burns adjacent to the limbus. Animals with and without lesions were tested for a vascular response to topical PGE1 and compound 48/80, with carbon used as an indicator. There was no response to PGE1 until 6 hours, at which time dense labeling of limbal vessels was observed. This response gradually decreased and by day 15, when labeling returned to control levels. No further permeability changes were seen for the duration of the experiment to day 90. Compound 48/80 gave four-plus labeling of the limbus and one-plus labeling of corneal vessels at all times during the experiment. The presence or absence of the thermal lesion did not change the degree of labeling. Histamine and bradykinin did not produce vascular labeling either with or without a corneal lesion.

Animals↗