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Biomedical subjects

V Wieczorek

Publications and source records attributed to V Wieczorek.

At least 19 recordsLinked to original sources
PubMed1989

Long-term care and management of Wilson's disease in the GDR.

Diagnosis, long-term management and family investigations of Wilson's disease are provided by selected clinical institutions in the GDR. From 187 patients detected since 1949, 111 are alive. In spite of the principal effectiveness of penicillamine treatment, confirmed by the disappearance of most of the central nervous system symptoms and successful professional rehabilitation of many patients, insufficient therapeutic discipline, psychosocial disturbances and penicillamine side-effects forcing its substitution by zinc or triethylenetetramine dihydrochloride in 14 cases need our further attention.

Adaptation, Psychological↗
PubMed1989

[Normal cerebrospinal fluid findings in spinal tumors--an analysis of 503 cases].

Till now almost nothing has been published about normal liquor findings in spinal cord tumours. Out of 503 cases there were normal findings of total proteins and cells in 30 cases (6 per cent). A connection with the severity of the compression-syndrome was not evident. Nevertheless liquor examinations are important in diseases of the medulla spinalis. This is especially useful in the differential diagnostical demarcation of inflammable spinal cord diseases, accompanying reactions or bleedings into the spinal channel.

Cerebrospinal Fluid↗
PubMed1986

Correlation between protein data in normal lumbar CSF and morphological findings of choroid plexus epithelium: a biochemical corroboration of barrier transport via tight junction pores.

Specific "reference areas" were derived from relationships between the proteins prealbumin, albumin, alpha 1-acid glycoprotein, alpha 2-macroglobulin, total transferrin, IgG, IgA, IgM, and the corresponding total protein in normal lumbar CSF samples. The procedure for calculating the boundary lines of these reference areas was carried out on the basis of double standard deviations in subgroups with total protein differences of 50 ml/l within the whole range of 150-400 ml/l CSF. The resulting biochemical data, hydrodynamic radii of the individual proteins investigated, and van Deurs' and Koehler's morphological findings on the existence of pores in the barrier-forming tight junctions of the choroid plexus epithelium could be surprisingly well correlated with one another, although these morphological findings were obtained in choroid plexus of the rat brain. The correlation allowed the conclusion that proteins undergo ultrafiltration via a pattern of tight junction pores with various diameters. However, the molecular mechanism seems to include an additional facilitating component.

Adult↗
PubMed1986

[Psychological test differentiation of neurotic and organically induced performance disorders].

Current methods of diagnosing psychological performance, which are primarily status-oriented, are inadequate to permit satisfactory differentiation between brain-organically and neurotically induced performance disturbances. We therefore attempted to contribute to the solution of this problem by adopting a new psychodiagnostic approach (measurement of intraindividual variability) and using multi-point measurements with the aid of attentiveness tests. The fact that 80 to 90% of 254 neurotic and brain-damaged subjects could be correctly diagnosed in the way indicates that the new approach to performance diagnosis is suitable for clinical use.

Adult↗
PubMed1986

[Empirical studies of the long-term stability of test norms].

Investigation of the long-term stability of psychological efficiency standards using a frequently applied intelligence test (Hawie -verbalpart). The test value distribution of two representative random tests of adults (from the beginning of 1950 in the FRG and from 1980 to 1983 in the GDR) was investigated and a comparison made together. Significant efficiency differences between the two random tests indicate defective long-term stability of test standards and the necessity to restandardize after 20 to 30 years. Because of significant differences between the old and new standard values and the high percentage of errors (26%), in classifying intelligence when applying the old standard values, the application of the new standards in the clinical diagnosis of intelligence is to be recommended.

Adult↗
PubMed1977

[The meningoencephalitis syndrome in brain tumor].

In an evaluation of the medical records of 765 patients with brain tumours treated since 1951 in our clinic we selected those cases where there was a pleocytosis in the cerebrospinal fluid of more than 15/3 cells. We were interested to know whether a connection which would help diagnosis could be made between the occurrence and the degree of pleocytosis, the biological valence and the localisation of the tumour. In 181 cases (24%) there were more than 15/3 cells. Therefore, no conclusions about biological valence and tumour localisation could be drawn from the aspect of the cell picture which we observed and from the degree of pleocytosis. Basically, the occurrence of pleocytoses was more frequent in the case of malignant tumours and those tumours associated with the fluid canal system (plexus papillomata, ependymomata, craniopharyngeomata). Problems of unspecific meningeal irritative syndromes are being discussed in connection with brain tumours. These are being clarified on the basis of selected cases.

Astrocytoma↗
PubMed1977

Brain acetylcholine, adenine nucleotides and their degradation products after intraperitoneal and intracerebral adenosine administration.

The paper describes adenosine effects on the acetylcholine synthesis and the profiles of adenine nucleotides, adenosine, inosine, and hypoxanthine in the rat brain in vivo after intracerebral (intraventricular) and intraperitoneal administration of adenosine. Intracerebral as well as extracerebral adenosine injection caused a dose- and time-dependent increase of the cerebral acetylcholine level, which was not accompanied by an equal development of the contents of adenine compounds and their degradation products. However, a considerable turnover of adenosine was observed in the brain after both routes of administration concerning the nucleotide as well as the degradation pathway. The kinetics of the purified enzymes of choline acetyltransferase and acetylcholinesterase were not influenced by adenosine. By this, the adenosine-caused increase of the cerebral acetylcholine cannot be explained by a direct molecular attack of adenosine on the enzymes of the synthesis or degradation of acetylcholine. An indirect mechanism which includes cAMP was discussed as a possible interpretation at present.

Acetylcholine↗